protein

TMEM175

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TMEM175: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

139Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

TMEM175 is a protein involved in neurodegeneration research. Key relationships include: contributes to, inhibits, associated with. Associated with Aging, Fibrosis, Inflammation. Connected to 71 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	TMEM175
Protein Type	Protein
Function	is a lysosomal potassium channel that plays critical roles in neuronal function and survival.
Subcellular Localization	lysosomes and late endosomes[@gomezsuaga2019]. The channel maintains lysosomal membrane potential, which is essential fo
Amino Acids	522 aa
Pathways	Lysosomal pH Homeostasis
UniProt ID	Search UniProt
GeneCards	TMEM175
Human Protein Atlas	TMEM175
Associated Diseases	Als, Ms, Neurodegeneration, Parkinson, Parkinson'S Disease
Interactions	JUN, AKT, VCP, PARKINSON, PARKINSON'S DISEASE, LYSOSOME
KG Connections	138 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: TMEM175 — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TMEM175["TMEM175"]
    TMEM175 -->|"regulates"| Lysosomal_Function["Lysosomal Function"]
    TMEM175 -->|"inhibits"| Aging["Aging"]
    TMEM175 -->|"inhibits"| Parkinson["Parkinson"]
    TMEM175 -->|"contributes to"| Neurodegeneration["Neurodegeneration"]
    TMEM175 -->|"contributes to"| Ms["Ms"]
    TMEM175 -->|"contributes to"| LAMP1["LAMP1"]
    TMEM175 -->|"contributes to"| Lysosomal_Degradation["Lysosomal Degradation"]
    TMEM175 -->|"contributes to"| Autophagy["Autophagy"]
    TMEM175 -->|"contributes to"| NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"]
    JUN["JUN"] -->|"inhibits"| TMEM175
    GBA["GBA"] -->|"contributes to"| TMEM175
    TFEB["TFEB"] -->|"contributes to"| TMEM175
    LAMP1 -->|"contributes to"| TMEM175
    LYSOSOME["LYSOSOME"] -->|"inhibits"| TMEM175
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"inhibits"| TMEM175
    PARKINSON["PARKINSON"] -->|"inhibits"| TMEM175
    AUTOPHAGY["AUTOPHAGY"] -->|"contributes to"| TMEM175
    MITOCHONDRIA["MITOCHONDRIA"] -->|"contributes to"| TMEM175
    MICROGLIA["MICROGLIA"] -->|"contributes to"| TMEM175

Outgoing (80)

Target	Relation	Type	Str
Lysosomal pH Homeostasis	involved_in	process	0.90
Lysosomal Ph Homeostasis	involved_in	process	0.90
Proton Conduction	mediates	process	0.90
Parkinson'S Disease	involved_in	disease	0.85
Parkinson'S Disease	risk_factor_for	disease	0.85
Parkinson'S Disease	associated_with	disease	0.85
PARKINSON'S DISEASE	implicated_in	entity	0.80
Lysosomal Function	regulates	process	0.75
Parkinson's Disease	associated_with	disease	0.75
REM sleep behavior disorder	associated_with	disease	0.70
Aging	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
Neurodegeneration	contributes_to	disease	0.65
Ms	contributes_to	disease	0.65
Parkinson	contributes_to	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Synucleinopathy	associated_with	disease	0.65
Rheumatoid Arthritis	inhibits	disease	0.65
Fibrosis	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Als	associated_with	disease	0.65
LAMP1	contributes_to	gene	0.60
TFEB	contributes_to	gene	0.60
GBA	contributes_to	gene	0.60
JUN	inhibits	gene	0.60
AKT	inhibits	gene	0.60
SMPD1	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
LRRK2	contributes_to	gene	0.60
VCP	interacts_with	gene	0.60
VPS13C	targets	gene	0.60
Lysosomal Degradation	contributes_to	pathway	0.60
Autophagy	contributes_to	pathway	0.60
Autophagy	associated_with	pathway	0.60
Lysosomal Degradation	associated_with	pathway	0.60
NEURODEGENERATIVE DISORDERS	contributes_to	gene	0.60
Alpha-Synuclein	contributes_to	pathway	0.60
PARKINSON	inhibits	gene	0.60
PARKINSON'S DISEASE	inhibits	gene	0.60
LYSOSOME	inhibits	gene	0.60
CYTOKINES	contributes_to	gene	0.60
PROINFLAMMATORY CYTOKINES	contributes_to	gene	0.60
NEURODEGENERATIVE DISEASES	contributes_to	gene	0.60
PARKINSON	contributes_to	gene	0.60
PARKINSON'S DISEASE	contributes_to	gene	0.60
MITOCHONDRIA	contributes_to	gene	0.60
NEURODEGENERATION	contributes_to	gene	0.60
AUTOPHAGY	inhibits	gene	0.60

Incoming (59)

Source	Relation	Type	Str
LAMP1	interacts_with	protein	0.95
LAMP2	interacts_with	protein	0.95
LAMP1	inhibits	protein	0.95
LAMP2	inhibits	protein	0.95
JUN	inhibits	gene	0.60
GBA	contributes_to	gene	0.60
TFEB	contributes_to	gene	0.60
LAMP1	contributes_to	gene	0.60
SNCA	associated_with	gene	0.60
GBA	associated_with	gene	0.60
SCARB2	associated_with	gene	0.60
SNCA-AS1	associated_with	gene	0.60
LAMP1	associated_with	entity	0.60
TFEB	associated_with	entity	0.60
CTSB	associated_with	gene	0.60
SNCA	contributes_to	gene	0.60
PINK1	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
GBA	implicated_in	gene	0.60
CHCHD10	interacts_with	gene	0.60
FUS	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
PARK7	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
SOD1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
TBK1	interacts_with	gene	0.60
TGM2	interacts_with	gene	0.60
BAG3	targets	gene	0.60
GBA1	targets	gene	0.60
LRRK2	targets	gene	0.60
RIT2	targets	gene	0.60
SCARB2	targets	gene	0.60
SNCA	targets	gene	0.60
BST1	biomarker_for	gene	0.60
LRRK2	biomarker_for	gene	0.60
RIT2	biomarker_for	gene	0.60
SNCA	biomarker_for	gene	0.60
INPP5F	associated_with	gene	0.60
LYSOSOME	inhibits	gene	0.60
PARKINSON'S DISEASE	inhibits	gene	0.60
PARKINSON	inhibits	gene	0.60
AUTOPHAGY	contributes_to	gene	0.60
MITOCHONDRIA	contributes_to	gene	0.60
MICROGLIA	contributes_to	gene	0.60
NEURODEGENERATIVE DISEASES	contributes_to	gene	0.60
PARKINSON'S DISEASE	contributes_to	gene	0.60
PARKINSON	contributes_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TMEM175

Understanding Entity Pages

Summary

Wiki Pages (21)

TMEM175 Gene

Novel Therapy Index

Parkinson's Disease

Synaptic Vesicle Trafficking in Parkinson's Disease

Autophagy-Lysosomal Pathway in Parkinson's Disease

TMEM175 Protein

Membrane Trafficking Pathway Dysfunction in Neurodegeneration

GIGYF2 — GRB10 Interacting GYF Protein 2

TMEM175 Lysosomal Overflow Valve in Parkinson's Disease

Dopaminergic Neurodegeneration

Lysoway Therapeutics

Lipid Droplet-Lysosome Axis Dysfunction Hypothesis in Parkinson's Disease

PD Ion Channel Modulator Companies

LAMP2 Protein

RIT2 — Ras-Like Without CAAX 2 (Rin)

Alzheimer's Disease Ion Channel Modulator Companies

Parkinson's Disease Lysosomal and Autophagy Companies

Therapy Ideas

LAMP2 Gene