Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about STX6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
STX6 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Als, Alzheimer, Ms. Connected to 15 entities in the SciDEX knowledge graph.
| Gene Symbol | STX6 |
| Protein Type | Receptor |
| Function | Syntaxin 6 is a Q-SNARE protein localized primarily to the trans-Golgi network (TGN) and endosomes. |
| Subcellular Localization | primarily to the *trans*-Golgi network (TGN) and endosomes |
| Ensembl ID | ENSG00000139334 |
| GeneCards | STX6 |
| Human Protein Atlas | STX6 |
| Associated Diseases | ALS, Alzheimer, Alzheimer's disease, Ms, Parkinson's disease |
| KG Connections | 42 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
STX6["<b>STX6</b>"]
Alzheimer{"Alzheimer"}
STX6 -->|"associated with"| Alzheimer
Als{"Als"}
STX6 -->|"associated with"| Als
Ms{"Ms"}
STX6 -->|"associated with"| Ms
MAPT["MAPT"]
STX6 -->|"associated with"| MAPT
neurodegeneration["neurodegeneration"]
STX6 -->|"implicated in"| neurodegeneration
DUSP10["DUSP10"]
DUSP10 -->|"associated with"| STX6
MAP1S["MAP1S"]
MAP1S -->|"associated with"| STX6
PSP["PSP"]
PSP -->|"associated with"| STX6
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
ALZHEIMER_S_DISEASE -->|"associated with"| STX6
ASTROCYTES["ASTROCYTES"]
ASTROCYTES -->|"associated with"| STX6
SP1["SP1"]
SP1 -->|"associated with"| STX6
APOE["APOE"]
APOE -->|"associated with"| STX6
TAU["TAU"]
TAU -->|"associated with"| STX6
KIF13A["KIF13A"]
KIF13A -->|"associated with"| STX6
TRIM24["TRIM24"]
TRIM24 -->|"associated with"| STX6
style STX6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Creutzfeldt-Jakob Disease | therapeutic_target | disease | 0.80 |
| Alzheimer | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| MAPT | associated_with | gene | 0.60 |
| TREM2 | causes | gene | 0.60 |
| neurodegeneration | causes | disease | 0.60 |
| Alzheimer's disease | causes | disease | 0.60 |
| Parkinson's disease | causes | disease | 0.60 |
| ALS | causes | disease | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MAPT | regulates | gene | 0.70 |
| PSP | regulates | gene | 0.70 |
| MOBP | regulates | gene | 0.70 |
| DUSP10 | associated_with | gene | 0.60 |
| MAP1S | associated_with | gene | 0.60 |
| PSP | associated_with | gene | 0.60 |
| SP1 | associated_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| TAU | associated_with | gene | 0.60 |
| KIF13A | associated_with | gene | 0.60 |
| TRIM24 | associated_with | gene | 0.60 |
| ATXN3 | causes | gene | 0.60 |
| BST1 | causes | gene | 0.60 |
| CR2 | causes | gene | 0.60 |
| ERBB1 | causes | gene | 0.60 |
| GPNMB | causes | gene | 0.60 |
| IL34 | causes | gene | 0.60 |
| PILRA | causes | gene | 0.60 |
| SHARPIN | causes | gene | 0.60 |
| C4A | regulates | gene | 0.60 |
| C4A | causes | gene | 0.60 |
| PSP | causes | gene | 0.60 |
| APOE | regulates | gene | 0.60 |
| DUSP10 | regulates | gene | 0.60 |
| EIF2AK3 | regulates | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| ASTROCYTES | associated_with | gene | 0.60 |
| B4GALNT1 | causes | gene | 0.60 |
| RUNX2 | regulates | gene | 0.60 |
| MOBP | causes | gene | 0.60 |
| RUNX2 | causes | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||