gene

STX6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STX6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

42Connections
0Hypotheses
0Analyses
11Outgoing
31Incoming

Summary

STX6 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Als, Alzheimer, Ms. Connected to 15 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolSTX6
Protein TypeReceptor
FunctionSyntaxin 6 is a Q-SNARE protein localized primarily to the trans-Golgi network (TGN) and endosomes.
Subcellular Localizationprimarily to the *trans*-Golgi network (TGN) and endosomes
Ensembl IDENSG00000139334
GeneCardsSTX6
Human Protein AtlasSTX6
Associated DiseasesALS, Alzheimer, Alzheimer's disease, Ms, Parkinson's disease
KG Connections42 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

STX6 Gene

gene · 569 words

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

psp-tauopathy

mechanism · 4377 words

Disease Progression and Staging in Progressive Supranuclear Palsy

mechanism · 3633 words

CBS/PSP Genetic Architecture

mechanism · 3431 words

Progressive Supranuclear Palsy (PSP) Pathway

mechanisms · 3322 words

Pathway Diagram

graph TD
    STX6["<b>STX6</b>"]
    Alzheimer{"Alzheimer"}
    STX6 -->|"associated with"| Alzheimer
    Als{"Als"}
    STX6 -->|"associated with"| Als
    Ms{"Ms"}
    STX6 -->|"associated with"| Ms
    MAPT["MAPT"]
    STX6 -->|"associated with"| MAPT
    neurodegeneration["neurodegeneration"]
    STX6 -->|"implicated in"| neurodegeneration
    DUSP10["DUSP10"]
    DUSP10 -->|"associated with"| STX6
    MAP1S["MAP1S"]
    MAP1S -->|"associated with"| STX6
    PSP["PSP"]
    PSP -->|"associated with"| STX6
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"associated with"| STX6
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"associated with"| STX6
    SP1["SP1"]
    SP1 -->|"associated with"| STX6
    APOE["APOE"]
    APOE -->|"associated with"| STX6
    TAU["TAU"]
    TAU -->|"associated with"| STX6
    KIF13A["KIF13A"]
    KIF13A -->|"associated with"| STX6
    TRIM24["TRIM24"]
    TRIM24 -->|"associated with"| STX6
    style STX6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (11)

TargetRelationTypeStr
Creutzfeldt-Jakob Diseasetherapeutic_targetdisease0.80
Alzheimerassociated_withdisease0.65
Alsassociated_withdisease0.65
Msassociated_withdisease0.65
MAPTassociated_withgene0.60

Incoming (31)

SourceRelationTypeStr
MAPTregulatesgene0.70
PSPregulatesgene0.70
MOBPregulatesgene0.70
DUSP10associated_withgene0.60
MAP1Sassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found