concept

B4GALNT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about B4GALNT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

49Connections

0Hypotheses

0Analyses

43Outgoing

6Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	B4GALNT1
Key Genes/Proteins	ST8SIA1, JUN, AND, NEURON, INFLAMMATION, COMPLEMENT
Related Diseases	Amyotrophic Lateral Sclerosis, Neurodegeneration, ALS, Inflammation, Als
Related Pathways	Complement

Wiki Pages (5)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    B4GALNT1["B4GALNT1"]
    B4GALNT1 -->|"catalyzes"| Ganglioside_Synthesis["Ganglioside Synthesis"]
    B4GALNT1 -->|"product_of"| Gangliosides["Gangliosides"]
    B4GALNT1 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    B4GALNT1 -->|"regulates"| ALS["ALS"]
    B4GALNT1 -->|"regulates"| Inflammation["Inflammation"]
    B4GALNT1 -->|"regulates"| Als["Als"]
    B4GALNT1 -->|"regulates"| ST8SIA1["ST8SIA1"]
    B4GALNT1 -->|"regulates"| JUN["JUN"]
    NEURODEGENERATION["NEURODEGENERATION"] -->|"regulates"| B4GALNT1
    INFLAMMATION["INFLAMMATION"] -->|"regulates"| B4GALNT1
    COMPLEMENT["COMPLEMENT"] -->|"regulates"| B4GALNT1
    ST8SIA1 -->|"regulates"| B4GALNT1
    JUN -->|"regulates"| B4GALNT1

Outgoing (43)

Target	Relation	Type	Str
Ganglioside Synthesis	catalyzes	process	0.90
Gangliosides	product_of	compound	0.85
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.80
Neurodegeneration	regulates	disease	0.65
ALS	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Als	regulates	disease	0.65
ST8SIA1	regulates	gene	0.60
JUN	regulates	gene	0.60
AND	regulates	gene	0.60
NEURON	associated_with	gene	0.60
Complement	regulates	pathway	0.60
Neuron	associated_with	cell_type	0.60
INFLAMMATION	regulates	gene	0.60
COMPLEMENT	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
Leptin	regulates	protein	0.60
Raf	regulates	protein	0.60
Sumo	regulates	protein	0.60
Ras	regulates	protein	0.60
App	regulates	protein	0.60
BST1	causes	gene	0.60
CR2	causes	gene	0.60
ERBB1	causes	gene	0.60
GPNMB	causes	gene	0.60
IL34	causes	gene	0.60
PILRA	causes	gene	0.60
SHARPIN	causes	gene	0.60
STX6	causes	gene	0.60
TREM2	causes	gene	0.60
Alzheimer's disease	causes	disease	0.60
Parkinson's disease	causes	disease	0.60
neurodegeneration	causes	disease	0.60
ALS	causes	disease	0.60
oxidative stress response	participates_in	pathway	0.60
Thalamus	expressed_in	brain_region	0.55
Hypothalamus	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55
ST3GAL2	interacts_with	gene	0.55
Alzheimer's disease	interacts_with	disease	0.55
lipid metabolism	participates_in	pathway	0.55
sphingolipid metabolism	participates_in	pathway	0.55
ST3GAL5	activates	gene	0.55

Incoming (6)

Source	Relation	Type	Str
NEURODEGENERATION	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
COMPLEMENT	regulates	gene	0.60
ST8SIA1	regulates	gene	0.60
JUN	regulates	gene	0.60
ATXN3	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

B4GALNT1

Understanding Entity Pages

Wiki Pages (5)

Peroxisomal Dysfunction

Gangliosides in Neurodegeneration

hereditary-spastic-paraplegia