gene

PILRA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PILRA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

83Connections

0Hypotheses

0Analyses

45Outgoing

38Incoming

Summary

Paired Immunoglobulin-Like Type 2 Receptor Alpha - immune receptor in neuroinflammation and neurodegeneration

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🧬 Gene Info

Gene Symbol	PILRA
Full Name	Paired Immunoglobulin-Like Type 2 Receptor Alpha
Chromosome	7q22.1
Protein Family	Paired immunoglobulin-like receptor family
Protein Type	Receptor
Function	is an inhibitory immune receptor expressed primarily on cells of the immune system.
Molecular Weight	31 kDa
Amino Acids	279 aa
Gene Type	Protein-coding
UniProt ID	Q9YH5Q
NCBI Gene ID	9317
Ensembl ID	ENSG00000137216
OMIM	604866
GeneCards	PILRA
Human Protein Atlas	PILRA
Associated Diseases	ALS, Alzheimer, Alzheimer's disease, Atherosclerosis, Macular Degeneration
Interactions	ZCWPW1, PILRB, SORL1, ABCA7, MAF, BIN1
KG Connections	83 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PILRA — AlphaFold Q9YH5Q Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PILRA["<b>PILRA</b>"]
    Alzheimer{"Alzheimer"}
    PILRA -->|"therapeutic target"| Alzheimer
    Aging{"Aging"}
    PILRA -->|"therapeutic target"| Aging
    Ms{"Ms"}
    PILRA -->|"therapeutic target"| Ms
    IDUA["IDUA"]
    PILRA -->|"therapeutic target"| IDUA
    TAU["TAU"]
    PILRA -->|"therapeutic target"| TAU
    GRN["GRN"]
    PILRA -->|"therapeutic target"| GRN
    neurodegeneration["neurodegeneration"]
    PILRA -->|"implicated in"| neurodegeneration
    ACE["ACE"]
    ACE -->|"therapeutic target"| PILRA
    TREM2["TREM2"]
    TREM2 -->|"therapeutic target"| PILRA
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"therapeutic target"| PILRA
    style PILRA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (45)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
ds-f50762b67605	provides_data_for	dataset	1.00
Alzheimer's Disease	therapeutic_target	disease	0.85
Alzheimer'S Disease	therapeutic_target	disease	0.85
Alzheimer	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Macular Degeneration	associated_with	disease	0.65
ALS	associated_with	disease	0.65
IDUA	therapeutic_target	gene	0.60
TAU	therapeutic_target	gene	0.60
GRN	therapeutic_target	gene	0.60
ZCWPW1	associated_with	gene	0.60
MAF	associated_with	gene	0.60
ABCA7	associated_with	gene	0.60
TNF	associated_with	gene	0.60
RIN3	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
SPI1	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
SHARPIN	causes	gene	0.60
STX6	causes	gene	0.60
TREM2	causes	gene	0.60
neurodegeneration	causes	disease	0.60
PILRB	interacts_with	gene	0.60
SORL1	interacts_with	gene	0.60
PILRB	regulates	gene	0.60
RET	regulates	gene	0.60
TREM2	regulates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
Endocytosis	associated_with	pathway	0.60
App	associated_with	protein	0.60
Alzheimer's disease	causes	disease	0.60
Parkinson's disease	causes	disease	0.60
ALS	causes	disease	0.60
oxidative stress response	participates_in	pathway	0.60
Alzheimer's disease	regulates	disease	0.60
ZCWPW1	interacts_with	gene	0.50
TNF	co_expressed_with	gene	0.50
ZCWPW1	co_expressed_with	gene	0.50
ZCWPW1	co_mentioned	gene	0.40
benchmark_ot_ad_answer_key:PILRA	data_in	dataset_row	0.00

Incoming (38)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
ds-f50762b67605	data_in	dataset	1.00
ACE	therapeutic_target	gene	0.60
TREM2	therapeutic_target	gene	0.60
TNF	associated_with	gene	0.60
MAF	associated_with	gene	0.60
ZCWPW1	associated_with	gene	0.60
ABCA7	associated_with	gene	0.60
MAF	interacts_with	gene	0.60
APOE	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
CD2AP	associated_with	gene	0.60
CD33	associated_with	gene	0.60
CLU	associated_with	gene	0.60
CR1	associated_with	gene	0.60
PICALM	associated_with	gene	0.60
ATXN3	causes	gene	0.60
BST1	causes	gene	0.60
CR2	causes	gene	0.60
ERBB1	causes	gene	0.60
GPNMB	causes	gene	0.60
IL34	causes	gene	0.60
BIN1	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
CD33	regulates	gene	0.60
CD55	regulates	gene	0.60
EPHA1	regulates	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER DISEASE	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AND	associated_with	gene	0.60
B4GALNT1	causes	gene	0.60
ABCA7	interacts_with	gene	0.50
MAF	co_expressed_with	gene	0.50
LXR	co_expressed_with	protein	0.50
MAF	co_mentioned	gene	0.40
benchmark_ot_ad_answer_key:PILRA	data_in	dataset_row	0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PILRA

Understanding Entity Pages

Summary

Wiki Pages (8)

PILRA Gene

Complement System

PILRA Protein

PILRB Protein

BST1 Gene - Bone Marrow Stromal Cell Antigen 1

IL34 Gene