gene

RIT2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RIT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

47Connections

0Hypotheses

0Analyses

34Outgoing

13Incoming

Summary

Page for RIT2 — Ras-Like Without CAAX 2 (Rin)

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🧬 Gene Info

Gene Symbol	RIT2
Full Name	Ras-Like Without CAAX 2 (Rin)
Chromosome	18q12.3
Function	encodes a neuron-specific small GTPase located on chromosome 18q12.
Primary Expression	Neurons (striatum, substantia nigra, hippocampus, cortex)
Amino Acids	217 aa
Exons	6
UniProt ID	Q99578
NCBI Gene ID	6014
Ensembl ID	ENSG00000152214
OMIM	609592
GeneCards	RIT2
Human Protein Atlas	RIT2
Symbol [@foo2020] RIT2 [@emanuele2015] Full Name	Ras-Like Without CAAX 2 (Rin)
Associated Diseases	Alzheimer, Parkinson
KG Connections	47 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RIT2 — AlphaFold Q99578 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RIT2["<b>RIT2</b>"]
    Neurodegeneration["Neurodegeneration"]
    RIT2 -->|"expressed in"| Neurodegeneration
    Als["Als"]
    RIT2 -->|"expressed in"| Als
    Alzheimer["Alzheimer"]
    RIT2 -->|"associated with"| Alzheimer
    Parkinson["Parkinson"]
    RIT2 -->|"associated with"| Parkinson
    ALS["ALS"]
    RIT2 -->|"expressed in"| ALS
    SNCA["SNCA"]
    RIT2 -->|"expressed in"| SNCA
    PARKINSON["PARKINSON"]
    RIT2 -->|"associated with"| PARKINSON
    Neuron["Neuron"]
    RIT2 -->|"expressed in"| Neuron
    ALZHEIMER["ALZHEIMER"]
    RIT2 -->|"associated with"| ALZHEIMER
    AND["AND"]
    RIT2 -->|"associated with"| AND
    IFN["IFN"]
    RIT2 -->|"expressed in"| IFN
    ANK1["ANK1"]
    RIT2 -->|"associated with"| ANK1
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    RIT2 -->|"associated with"| PARKINSON_S_DISEASE
    IFN__["IFN-Gamma"]
    RIT2 -->|"expressed in"| IFN__
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
    RIT2 -->|"expressed in"| ALPHA_SYNUCLEIN
    Alpha_Synuclein["Alpha-Synuclein"]
    RIT2 -->|"expressed in"| Alpha_Synuclein
    ANK1["ANK1"]
    ANK1 -->|"associated with"| RIT2
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"associated with"| RIT2
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"expressed in"| RIT2
    GENES["GENES"]
    GENES -->|"associated with"| RIT2
    PARKINSON["PARKINSON"]
    PARKINSON -->|"associated with"| RIT2
    Substantia_Nigra["Substantia Nigra"]
    RIT2 -->|"expressed in"| Substantia_Nigra
    neurodegeneration["neurodegeneration"]
    RIT2 -->|"implicated in"| neurodegeneration

Outgoing (34)

Target	Relation	Type	Str
Neurodegeneration	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Alzheimer	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
ALS	expressed_in	disease	0.65
SNCA	expressed_in	gene	0.60
ANK1	associated_with	gene	0.60
SCARB2	targets	gene	0.60
SNCA	targets	gene	0.60
TMEM175	targets	gene	0.60
VPS13C	targets	gene	0.60
SNCA	biomarker_for	gene	0.60
TMEM175	biomarker_for	gene	0.60
PARKINSON	associated_with	gene	0.60
Neuron	expressed_in	cell_type	0.60
ALZHEIMER	associated_with	gene	0.60
AND	associated_with	gene	0.60
IFN	expressed_in	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
IFN-Γ	expressed_in	gene	0.60
ALPHA-SYNUCLEIN	expressed_in	gene	0.60
Alpha-Synuclein	expressed_in	pathway	0.60
Interferon	expressed_in	protein	0.60
Α-Synuclein	expressed_in	protein	0.60
Ras	expressed_in	protein	0.60
Parkinson's disease	expressed_in	disease	0.60
Alzheimer's disease	expressed_in	disease	0.60
Substantia Nigra	expressed_in	brain_region	0.55
ALZHEIMER	expressed_in	gene	0.50
PARKINSON	expressed_in	gene	0.50
Parkinson's Disease	expressed_in	disease	0.50
disease	expressed_in	disease	0.50
ALZHEIMER'S	expressed_in	concept	0.50
PARKINSON'S	expressed_in	concept	0.50

Incoming (13)

Source	Relation	Type	Str
ANK1	associated_with	gene	0.60
SNCA	expressed_in	gene	0.60
ANK1	expressed_in	gene	0.60
BAG3	targets	gene	0.60
GBA1	targets	gene	0.60
LRRK2	targets	gene	0.60
BST1	biomarker_for	gene	0.60
LRRK2	biomarker_for	gene	0.60
ALZHEIMER	associated_with	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
GENES	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
ank1	expressed_in	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

RIT2

Understanding Entity Pages

Summary

Wiki Pages (5)

RIT2 — Ras-Like Without CAAX 2 (Rin)

Polygenic Risk Score Integration Panel for Alzheimer's and Parkinson's Disease

BST1 Gene - Bone Marrow Stromal Cell Antigen 1