gene

C6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about C6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections
3Hypotheses
0Analyses
8Outgoing
2Incoming

No summary available yet. View on Wiki →

🧬 Gene Info
Gene SymbolC6
Full NameComplement Component 6
Chromosome5p13.1
Protein FamilyComplement system (terminal pathway)
FunctionC6 functions exclusively in the terminal complement pathway[@structure2015][@complement2018]:
Subcellular LocalizationPlasma, cell membrane
Molecular Weight120 kDa
Amino Acids922 aa
UniProt IDP13671
GeneCardsC6
Human Protein AtlasC6
N-terminal domainContains cysteine-rich repeats (MCP/CD46-like)
Thrombospondin type I repeatsProtein-protein interaction motifs
C-terminal domainCritical for complex formation with C5b-7
Disulfide bondsStabilize protein structure
Associated Diseasesneurodegeneration
InteractionsCYP46A1, CYP7B1, SARM1, C3
KG Connections10 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: C6 — AlphaFold P13671 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

c6

gene · 1205 words

Circadian Rhythm in Neurodegeneration

mechanism · 4939 words

Amyloid Cascade Pathway

mechanism · 4149 words

mitochondrial-dynamics-dysfunction-parkinsons

general · 3785 words

er-stress-neurodegeneration

mechanism · 3696 words

alpha-lipoic-acid-neurodegeneration

therapeutic · 3435 words

Pathway Diagram

flowchart TD
    N0["C6"]
    N1["C3"]
    N1 -->|"activates"| N0
    N2["C2"]
    N2 -->|"expressed in"| N0
    N3["CYP46A1"]
    N0 -->|"activates"| N3
    N4["CYP7B1"]
    N0 -->|"activates"| N4
    N5["PSP"]
    N0 -->|"regulates"| N5
    N6["TG2"]
    N0 -->|"regulates"| N6
    N7["blood-brain barrier"]
    N0 -->|"participates in"| N7
    N8["SARM1"]
    N0 -->|"activates"| N8
    N9["neuroinflammation"]
    N0 -->|"regulates"| N9
    N10["autophagy pathway"]
    N0 -->|"participates in"| N10

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    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
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    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
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    classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
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    class N0 gene
    class N1 gene
    class N2 gene
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 pathway
    class N8 gene
    class N9 disease
    class N10 pathway

Outgoing (8)

TargetRelationTypeStr
CYP46A1activatesgene0.60
CYP7B1activatesgene0.60
PSPregulatesgene0.60
neuroinflammationregulatesdisease0.60
TG2regulatesgene0.60

Incoming (2)

SourceRelationTypeStr
C3activatesgene0.60
C2expressed_ingene0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
HDAC6 Selective Inhibition to Restore Acetylation Balance an 0.577 structural biology What is the atomic-resolution structure
HDAC6 Activation as SCFA-Mediated Neuroprotective Mechanism 0.537 neurodegeneration Do SCFAs directly modulate α-synuclein a
HDAC6 Inhibition for Dual Restoration of Microtubule Stabili 0.459 neurodegeneration Which tau PTMs are both disease-specific

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (4)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Salidroside ameliorates diabetic amyotrophy by targeting Caspase-3 to inhibit ap [PMID:40715275] Wang H, Yousaf W, Haseeb A, Wang Z, Zhen Sci Rep 2025 0
Effect of Calebin-A on Critical Genes Related to NAFLD: A Protein-Protein Intera [PMID:38751599] Mahmoudi A, Hajihasani MM, Majeed M, Jam Curr Genomics 2024 0
HDAC6 as a Prognostic Factor and Druggable Target in HER2-Positive Breast Cancer [PMID:39594707] Cortesi M, Bravaccini S, Ravaioli S, Pet Cancers (Basel) 2024 0
Acute heat stress reduces viability but increases lactate secretion of porcine i [PMID:34392171] Yang CX, Chen L, Yang YW, Mou Q, Du ZQ Theriogenology 2021 0