Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about C2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive page on C2 (Complement Component 2), a central protein in the classical complement pathway, implicated in Alzheimer's disease, age-related macular degeneration, and systemic lupus erythematosus.
| Gene Symbol | C2 |
| Full Name | Complement Component 2 |
| Chromosome | 6p21.3 |
| Function | encodes a 732-amino acid zymogen that, upon activation, generates the C3 convertase complex essential for complement cascade amplification. |
| Molecular Weight | 83 kDa |
| Amino Acids | 732 aa |
| Exons | 18 |
| UniProt ID | P06610 |
| NCBI Gene ID | 717 |
| Ensembl ID | ENSG00000166278 |
| OMIM | 120490 |
| GeneCards | C2 |
| Human Protein Atlas | C2 |
| Encoded Protein | Complement component C2 |
| Associated Diseases | autism spectrum disorder |
| Interactions | SIRT2, MAVS, PI3KC3 |
| KG Connections | 17 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
C2["C2"]
neurodegeneration["neurodegeneration"]
C2 -->|"implicated_in"| neurodegeneration
style C2 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
style neurodegeneration fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| SIRT2 | inhibits | gene | 0.60 |
| TGFB1 | associated_with | gene | 0.60 |
| C3 | associated_with | gene | 0.60 |
| C5 | associated_with | gene | 0.60 |
| MAVS | activates | gene | 0.60 |
| C6 | expressed_in | gene | 0.60 |
| Huntington's disease | inhibits | disease | 0.60 |
| autism spectrum disorder | associated_with | disease | 0.60 |
| PI3KC3 | interacts_with | gene | 0.60 |
| PI3K-AKT-mTOR signaling | participates_in | pathway | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| multiple sclerosis | activates | disease | 0.60 |
| NF-kB signaling | participates_in | pathway | 0.60 |
| lipid metabolism | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| astrocytes | expressed_in | cell_type | 0.60 |
| oligodendrocytes | expressed_in | cell_type | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95 | 0.695 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| HDAC2-Specific Repression of PU.1 Pioneer Factor Target Site | 0.415 | neurodegeneration | How does HDAC1/2 deletion specifically e |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.520
neurodegeneration | 2026-04-10 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Zhi-Gan Formula improved insomnia and anxiety comorbidity in a mouse model via P [PMID:41525914] | Liu R, Wu Z, Yin Y, Song C, Zhang C et a | J Ethnopharmacol | 2026 | 0 |
| Triterpenoid saponins from Platycodon grandiflorus exhibit antidepressant-like e [PMID:41539634] | Yoon S, Chun E, Iqbal H, Kim SH, Kim SY | J Ethnopharmacol | 2026 | 0 |
| Integrative GWAS identifies novel loci and genetic links between psychiatric and [PMID:41927769] | Song Y, Jiang Y, Tian H, Glessner J, Hak | Mol Psychiatry | 2026 | 0 |
| Designed Liquid Crystalline Nanoassemblies From Clinically Validated Polyunsatur [PMID:41937329] | Akanchise T, Luo F, Angelov B, Deng Y, A | Adv Healthc Mater | 2026 | 0 |
| Single transient exposure to low-frequency low-intensity electrical stimulation [PMID:41942002] | Marcotto GS, Borghetti M, Bitraj J, Cava | Neuropharmacology | 2026 | 0 |
| Serpina1e mediates the exercise-induced enhancement of hippocampal memory in mal [PMID:41957371] | Kim H, Shin S, Han J, Yun K, Kim JS et a | Nat Commun | 2026 | 0 |
| Ubiquinol Ameliorates Social Disruption-induced Behavioral Changes via Modulatin [PMID:41962635] | Chen CW, Huang BR, Yeh WL, Huang SS, Cha | Behav Brain Res | 2026 | 0 |
| Dietary Advanced Glycation End Products Induced Anxiety- and Depression-like Beh [PMID:41962780] | Ma T, He Z, Yang G, Cai J, Qin LQ et al. | J Nutr Biochem | 2026 | 0 |
| BDNF Protects Against Neuronal Damage Induced by TNF and β-Amyloid Peptides by T [PMID:41964857] | Ramírez-Olvera A, Almazán JL, Pérez-Mart | Neurochemical research | 2026 | 0 |
| Nanopiezoelectric 3D-Bioprinted Neural Organoid Models Epileptic Neuron-Microgli [PMID:41877549] | Chu J, Hu K, Lee WF, Xu SJ, Sun Z, Xu Y, | Nano letters | 2026 | 0 |