Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about C2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive page on C2 (Complement Component 2), a central protein in the classical complement pathway, implicated in Alzheimer's disease, age-related macular degeneration, and systemic lupus erythematosus.
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| Gene Symbol | C2 |
| Full Name | Complement Component 2 |
| Chromosome | 6p21.3 |
| Function | encodes a 732-amino acid zymogen that, upon activation, generates the C3 convertase complex essential for complement cascade amplification. |
| Molecular Weight | 83 kDa |
| Amino Acids | 732 aa |
| Exons | 18 |
| UniProt ID | P06610 |
| NCBI Gene ID | 717 |
| Ensembl ID | ENSG00000166278 |
| OMIM | 120490 |
| GeneCards | C2 |
| Human Protein Atlas | C2 |
| Associated Diseases | autism spectrum disorder |
| Interactions | MAVS, PI3KC3, SIRT2 |
| KG Connections | 17 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
C2["C2"]
neurodegeneration["neurodegeneration"]
C2 -->|"implicated_in"| neurodegeneration
style C2 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
style neurodegeneration fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| SIRT2 | inhibits | gene | 0.60 |
| TGFB1 | associated_with | gene | 0.60 |
| C6 | expressed_in | gene | 0.60 |
| autism spectrum disorder | associated_with | disease | 0.60 |
| oligodendrocytes | expressed_in | cell_type | 0.60 |
| PI3KC3 | interacts_with | gene | 0.60 |
| PI3K-AKT-mTOR signaling | participates_in | pathway | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| multiple sclerosis | activates | disease | 0.60 |
| NF-kB signaling | participates_in | pathway | 0.60 |
| lipid metabolism | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| astrocytes | expressed_in | cell_type | 0.60 |
| C3 | associated_with | gene | 0.60 |
| C5 | associated_with | gene | 0.60 |
| MAVS | activates | gene | 0.60 |
| Huntington's disease | inhibits | disease | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95 | 0.885 | alzheimers | Circuit-level neural dynamics in neurode |
| HDAC2 Phospho-Lock Window for Synaptic Gene Silencing | 0.643 | neurodegeneration | What is the optimal therapeutic window d |
| Oxygen Pressure-Dependent BDNF Cascade: DHHC2/PSD95 Stabiliz | 0.580 | neurodegeneration | What are the optimal oxygen pressure, du |
| Gut-derived butyrate reprograms microglia for amyloid cleara | 0.525 | alzheimers | Gut-Brain Axis Therapeutics for AD |
| HDAC2-Specific Repression of PU.1 Pioneer Factor Target Site | 0.415 | neurodegeneration | How does HDAC1/2 deletion specifically e |
| Gut butyrate deficiency impairs microglial amyloid clearance | 0.380 | alzheimers | Gut-Brain Axis Therapeutics for Alzheime |
| G4C2 RNA Decoy Therapeutics | 0.000 | - | TDP-43 phase separation therapeutics for |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.724
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Synaptic plasticity and protein expression analysis in mPFC | exploratory | insomnia-anxiety comorbidity | 0.850 | 0.00 | mPFC brain slices from PCPA-tr | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning C2 in their description or question text
Score: 0.380 · alzheimers · 2026-04-27
Gut dysbiosis in Alzheimer's disease reduces butyrate-producing bacteria (Faecalibacterium prausnitzii, Roseburia intest
Score: 0.000 · unknown disease · 2026-04-28
Engineered decoy RNAs containing modified G4C2 repeats could sequester pathological RNA species and prevent their interf