gene 1,544 words KG: SLC6A2 2026-03-27
kind:genesection:genestopic:parkinsonstopic:alzheimerstopic:depression
Contents

SLC6A2 — Norepinephrine Transporter

🧬 Gene Info
Gene SymbolSLC6A2
Full NameNorepinephrine Transporter
Chromosome16q12.2
Protein TypeTransporter
Functionis a gene encoding a critical membrane transport protein responsible for the reuptake of norepinephrine (noradrenaline) from the synaptic cleft back into presynaptic neurons.
Primary Expressionnoradrenergic neurons of the central nervous system:
Molecular Weight70 kDa
Amino Acids617 aa
PathwaysEpigenetic, autophagy pathway
UniProt ID[P23975](https://www.uniprot.org/uniprot/P23975)
Ensembl IDENSG00000170270
OMIM163910
GeneCardsSLC6A2
Human Protein AtlasSLC6A2
Associated DiseasesALS, Alzheimer, Alzheimer'S Disease, Anxiety, Autism
Known Drugs/Compoundsantidepressant drugs
InteractionsJUN, SLC1A1, HTR2A, CACNA1H, GABRB2, GRIA1
KG Connections217 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (8)

Noradrenergic-Tau Propagation Blockade
Score: 0.51
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53

Related Analyses (4)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (10)

Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with
CACNA1H Gene
gene · KG edge: associated_with
CACNA1B Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

SLC6A2 associated_with SNCA
SLC6A2 provides_data_for ds-83b31ef18d49
SLC6A2 associated_with SLC6A3
SLC6A2 associated_with ABCB1
SLC6A2 associated_with SLC6A4
SLC6A2 associated_with GSTP1
SLC6A2 associated_with CYP3A4
SLC6A2 associated_with ABCG2
SLC6A2 associated_with ADRB2
SLC6A2 activates JUN