Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about caspases: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
Knowledge base pages for this entity
graph TD
caspases["<b>caspases</b>"]
apoptosis["apoptosis"]
caspases -->|"activates"| apoptosis
caspases -->|"causes"| apoptosis
BECN1["BECN1"]
caspases -->|"inhibits"| BECN1
caspases -->|"regulates"| apoptosis
gain_of_function["gain_of_function"]
caspases -->|"causes"| gain_of_function
style caspases fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cell Death | mediates | process | 0.97 |
| Apoptosis Execution | mediates | process | 0.95 |
| apoptosis | activates | phenotype | 0.90 |
| apoptosis | causes | phenotype | 0.90 |
| Innate Immunity | involved_in | process | 0.90 |
| BECN1 | inhibits | gene | 0.80 |
| apoptosis | regulates | process | 0.70 |
| CELL_DEATH | activates | phenotype | 0.64 |
| TNF | activates | entity | 0.60 |
| gain_of_function | causes | phenotype | 0.56 |
| GAIN | activates | gene | 0.50 |
| RIPK1 | activates | gene | 0.50 |
| RIPK3 | associated_with | gene | 0.50 |
| RIPK1 | associated_with | gene | 0.50 |
| NLRP3 | associated_with | protein | 0.50 |
| RIPK3 | activates | gene | 0.50 |
| TNFR1 | activates | protein | 0.50 |
| MITOCHONDRIA | activates | cell_type | 0.50 |
| CYTOCHROME C | activates | protein | 0.50 |
| CASPASE-6 | associated_with | protein | 0.50 |
| inflammation | activates | pathway | 0.50 |
| CELL DEATH | activates | concept | 0.50 |
| BCL-XL | activates | protein | 0.50 |
| BCL-2 | activates | protein | 0.50 |
| Proteins | activates | protein | 0.50 |
| BCL-2 | regulates | protein | 0.50 |
| Proteins | regulates | protein | 0.50 |
| Necroptosis | activates | pathway | 0.50 |
| CELL DEATH | interacts_with | concept | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity