protein

TNFR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNFR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

386Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

TNFR1 is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, expressed in. Associated with ALS, Aging, Als. Connected to 108 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	TNFRSF1A
Full Name	Tumor necrosis factor receptor superfamily member 1A
Aliases	TNFR1, TNF-R1, p55, p60
Chromosome	12p13.31
Function	TNFRSF1A encodes TNFR1, a receptor that plays central roles in inflammation and cell survival:
Molecular Weight	~55 kDa
Amino Acids	455 aa
Exons	10
Pathways	NF-κB Signaling, NF-κB, MAPK Pathway, MAPK
UniProt ID	P19438
NCBI Gene ID	7132
Ensembl ID	ENSG00000082258
OMIM	191190
GeneCards	TNFRSF1A
Human Protein Atlas	TNFRSF1A
Associated Diseases	Atherosclerosis, Diabetes, Ms
Interactions	OCLN, ICAM1, BMAL1, ARNT, TNF, CRY1
KG Connections	154 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TNFR1 — AlphaFold P19438 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TNFR1["TNFR1"] -->|"regulates"| Tumor["Tumor"]
    TNFR1["TNFR1"] -->|"expressed in"| Als["Als"]
    TNFR1["TNFR1"] -->|"regulates"| Leukemia["Leukemia"]
    TNFR1["TNFR1"] -->|"activates"| Cancer["Cancer"]
    TNFR1["TNFR1"] -->|"regulates"| Als_1["Als"]
    TNFR1["TNFR1"] -->|"regulates"| Lymphoma["Lymphoma"]
    TNF["TNF"] -->|"interacts"| TNFR1["TNFR1"]
    GFAP["GFAP"] -->|"regulates"| TNFR1["TNFR1"]
    TNF_2["TNF"] -->|"expressed in"| TNFR1["TNFR1"]
    TNFR2["TNFR2"] -->|"expressed in"| TNFR1["TNFR1"]
    style TNFR1 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (266)

Target	Relation	Type	Str
cytotoxic signaling	activates	process	0.90
pro-inflammatory processes	promotes	process	0.90
neuroinflammation	mediates	process	0.90
astrocyte death	mediates	process	0.85
intestinal epithelial cell	internalization	cell_type	0.80
CASP1	activates	gene	0.80
most cell types	expressed_in	cell_type	0.80
solTNF	binds_to	protein	0.80
tmTNF	binds_to	protein	0.80
apoptosis pathway	participates_in	pathway	0.80
necroptosis	participates_in	pathway	0.80
Tumor	regulates	disease	0.75
Inflammation	activates	disease	0.75
TNF-Α	activates	gene	0.70
NF-kB signaling	participates_in	pathway	0.70
necroptosis	regulates	process	0.70
Als	expressed_in	disease	0.65
Leukemia	regulates	disease	0.65
Cancer	activates	disease	0.65
Als	regulates	disease	0.65
Lymphoma	regulates	disease	0.65
Ms	regulates	disease	0.65
Anxiety	activates	disease	0.65
Ms	inhibits	disease	0.65
Als	protects_against	disease	0.65
Tumor	protects_against	disease	0.65
Ms	protects_against	disease	0.65
Aging	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Ms	activates	disease	0.65
ALS	expressed_in	disease	0.65
Als	activates	disease	0.65
Depression	activates	disease	0.65
Infection	activates	disease	0.65
Rheumatoid Arthritis	activates	disease	0.65
Inflammatory Bowel Disease	activates	disease	0.65
Psoriasis	activates	disease	0.65
Stroke	activates	disease	0.65
Autoimmune	inhibits	disease	0.65
Rheumatoid Arthritis	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Infection	protects_against	disease	0.65
Alzheimer	protects_against	disease	0.65
Neuroinflammation	protects_against	disease	0.65
ALS	protects_against	disease	0.65
Inflammation	protects_against	disease	0.65
Als	inhibits	disease	0.65
Necroptosis	regulates	disease	0.65
Alzheimer	activates	disease	0.65

Incoming (120)

Source	Relation	Type	Str
TNF-α	binds_to	protein	0.95
CASP8	interacts_with	gene	0.85
EFHD2	interacts_with	gene	0.80
TNF	interacts_with	protein	0.70
INFLAMMATION	activates	gene	0.70
GFAP	regulates	gene	0.60
TNF	expressed_in	gene	0.60
TNFR2	expressed_in	gene	0.60
ATG3	regulates	gene	0.60
IRF1	activates	gene	0.60
TNF	activates	gene	0.60
STAT1	activates	gene	0.60
RB1CC1	regulates	gene	0.60
TNF	regulates	gene	0.60
FIP200	protects_against	gene	0.60
ATG9A	protects_against	gene	0.60
CD19	regulates	gene	0.60
BECN1	regulates	gene	0.60
TLR3	regulates	gene	0.60
RIPK1	regulates	gene	0.60
RIPK3	activates	gene	0.60
LC3	protects_against	gene	0.60
SLC7A11	activates	gene	0.60
TNFR2	interacts_with	gene	0.60
KMT2B	inhibits	entity	0.60
TNF	upregulates	entity	0.60
TNFA	binds_to	protein	0.60
TNF	inhibits	gene	0.60
MLKL	regulates	gene	0.60
TAX1BP1	regulates	gene	0.60
RIPK3	regulates	gene	0.60
TNFR2	activates	gene	0.60
RIPK1	activates	gene	0.60
RIPK1	interacts_with	gene	0.60
GAIN	regulates	gene	0.60
TNFRSF1A	interacts_with	gene	0.60
TRADD	regulates	gene	0.60
BDNF	activates	gene	0.60
TRKB	activates	gene	0.60
MLCK	activates	gene	0.60
COFILIN	inhibits	gene	0.60
HMGB1	inhibits	gene	0.60
TNF	causes	gene	0.60
BDNF	associated_with	gene	0.60
TNFR2	causes	gene	0.60
FAS	expressed_in	gene	0.60
TLR3	activates	gene	0.60
FADD	activates	gene	0.60
CTSD	expressed_in	gene	0.60
MMP9	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TNFR1

Understanding Entity Pages

Summary

Wiki Pages (21)

TNFRSF1A Gene

cbs-psp-daily-action-plan

NF-κB Signaling Pathway in Neurodegeneration

Synaptic Plasticity Deficits in Neurodegeneration

Tumor Necrosis Factor Alpha (TNF-α) as a Neurodegenerative Disease Biomarker

Neuroinflammation in Amyotrophic Lateral Sclerosis

Necroptosis Pathway in Neurodegeneration

AMPA Receptor Neurons

Demyelination

Apoptosis Pathway in Neurodegeneration

Apoptosis in Neurodegeneration

IL32

Regulated Necrosis Hypothesis in Parkinson's Disease

Neuroinflammation in Alzheimer's Disease

NF-κB Signaling in Neurodegeneration

Neuroinflammation Pathway

Astrocyte-Mediated Neuroinflammation

Neuroinflammation in Neurodegeneration

TNF Signaling Pathway in Neurodegeneration