gene

CASR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections

0Hypotheses

0Analyses

24Outgoing

5Incoming

0Experiments

0Debates

Summary

Calcium-Sensing Receptor gene implicated in neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	CASR
Full Name	Calcium-Sensing Receptor
Chromosome	3q21.1
Protein Type	Receptor
Function	is a class C G protein-coupled receptor that functions as the principal sensor of extracellular calcium concentrations in the body.
Primary Expression	Brain (cerebellum, hippocampus, cortex), Parathyroid, Kidney, Pancreas
Exons	11
Pathways	Dopaminergic Calcium Handling
UniProt ID	Q9UII2
NCBI Gene ID	846
Ensembl ID	ENSG00000036828
OMIM	601199
GeneCards	CASR
Human Protein Atlas	CASR
Associated Diseases	Parkinson's Disease
KG Connections	29 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CASR — AlphaFold Q9UII2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CASR Gene

gene · 1827 words

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Pathway Diagram

graph TD
    CASR["CASR"]
    Dopaminergic_Calcium_Handling["Dopaminergic Calcium Handling"]
    CASR -->|"regulates"| Dopaminergic_Calcium_Handling
    Parkinson_s_Disease{"Parkinson's Disease"}
    CASR -->|"associated_with"| Parkinson_s_Disease
    Aging{"Aging"}
    CASR -->|"expressed_in"| Aging
    Neurodegeneration{"Neurodegeneration"}
    CASR -->|"expressed_in"| Neurodegeneration
    Parkinson{"Parkinson"}
    CASR -->|"expressed_in"| Parkinson
    AGING(["AGING"])
    AGING -->|"expressed_in"| CASR
    NEURODEGENERATION(["NEURODEGENERATION"])
    NEURODEGENERATION -->|"expressed_in"| CASR
    GENES(["GENES"])
    GENES -->|"regulates"| CASR
    PARKINSON(["PARKINSON"])
    PARKINSON -->|"expressed_in"| CASR
    style CASR fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (24)

Target	Relation	Type	Str
Dopaminergic Calcium Handling	regulates	process	0.85
Parkinson'S Disease	associated_with	disease	0.85
Parkinson's Disease	associated_with	disease	0.75
Neurodegeneration	expressed_in	disease	0.65
Parkinson	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
Aging	encodes	disease	0.65
Neurodegeneration	encodes	disease	0.65
Parkinson	encodes	disease	0.65
Neuron	encodes	cell_type	0.60
AGING	encodes	gene	0.60
PARKINSON	encodes	gene	0.60
Dopaminergic	regulates	cell_type	0.60
Neuron	expressed_in	cell_type	0.60
PARKINSON	expressed_in	gene	0.60
GENES	regulates	gene	0.60
AND	regulates	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
NEURON	expressed_in	gene	0.60
PARKINSON'S DISEASE	expressed_in	gene	0.60
AGING	expressed_in	gene	0.60
Substantia Nigra	expressed_in	brain_region	0.55
disease	interacts_with	disease	0.50
DOPAMINERGIC	interacts_with	concept	0.50

Incoming (5)

Source	Relation	Type	Str
AGING	expressed_in	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
GENES	regulates	gene	0.60
PARKINSON	expressed_in	gene	0.60
NEURON	encodes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CASR in their description or question text

No additional research found