Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Substantia Nigra: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Substantia Nigra is an entity related to neurodegeneration research. Key relationships include: expressed in, associated with, interacts with. Associated with ALS, Aging, Inflammation. Connected to 80 entities in the SciDEX knowledge graph.
Knowledge base pages for this entity
graph TD
Substantia_Nigra["Substantia Nigra"] -->|"interacts"| Dopamine["Dopamine"]
Substantia_Nigra["Substantia Nigra"] -->|"regulates"| Dopamine_1["Dopamine"]
Substantia_Nigra["Substantia Nigra"] -->|"activates"| Dopamine_2["Dopamine"]
Parkinson_s_Disease["Parkinson's Disease"] -->|"associated"| Substantia_Nigra["Substantia Nigra"]
Dopamine_3["Dopamine"] -->|"interacts"| Substantia_Nigra["Substantia Nigra"]
GCASE["GCASE"] -->|"expressed in"| Substantia_Nigra["Substantia Nigra"]
NEURON["NEURON"] -->|"expressed in"| Substantia_Nigra["Substantia Nigra"]
style Substantia_Nigra fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Dopamine | interacts_with | entity | 0.70 |
| Dopamine | regulates | entity | 0.70 |
| Dopamine | activates | entity | 0.70 |
| PARKINSON'S | protects_against | concept | 0.50 |
| DOPAMINERGIC | protects_against | concept | 0.50 |
| PARKINSON'S | causes | concept | 0.50 |
| SYNUCLEIN | causes | concept | 0.50 |
| DOPAMINE | causes | concept | 0.50 |
| α-SYNUCLEIN | causes | concept | 0.50 |
| OLIGODENDROCYTES | activates | concept | 0.50 |
| 6-OHDA | protects_against | concept | 0.50 |
| SYNUCLEIN | protects_against | concept | 0.50 |
| DOPAMINERGIC | associated_with | concept | 0.50 |
| HYPOTHALAMUS | associated_with | concept | 0.50 |
| DOPAMINERGIC | interacts_with | concept | 0.50 |
| SYNUCLEIN | interacts_with | concept | 0.50 |
| DOPAMINERGIC NEURONS | interacts_with | concept | 0.50 |
| RAPAMYCIN | interacts_with | concept | 0.50 |
| CENTRAL NERVOUS SYSTEM | interacts_with | concept | 0.50 |
| PARKINSON'S | associated_with | concept | 0.50 |
| SYNUCLEIN | associated_with | concept | 0.50 |
| α-SYNUCLEIN | associated_with | concept | 0.50 |
| NEURODEGENERATIVE DISEASE | associated_with | concept | 0.50 |
| PARKINSON'S | inhibits | concept | 0.50 |
| ST3GAL2 | inhibits | concept | 0.50 |
| GENE EXPRESSION | inhibits | concept | 0.50 |
| DOPAMINERGIC | causes | concept | 0.50 |
| DOPAMINERGIC NEURONS | causes | concept | 0.50 |
| DOPAMINERGIC NEURONS | associated_with | concept | 0.50 |
| PARKINSON'S | interacts_with | concept | 0.50 |
| DOPAMINERGIC | inhibits | concept | 0.50 |
| DOPAMINE | inhibits | concept | 0.50 |
| DOPAMINERGIC NEURONS | inhibits | concept | 0.50 |
| DOPAMINE | associated_with | concept | 0.50 |
| DOPAMINERGIC | activates | concept | 0.50 |
| STRIATUM | activates | concept | 0.50 |
| DOPAMINERGIC NEURONS | activates | concept | 0.50 |
| PI3K/AKT/mTOR | activates | pathway | 0.50 |
| Proteins | activates | protein | 0.50 |
| MTOR SIGNALING | activates | concept | 0.50 |
| STRIATUM | associated_with | concept | 0.50 |
| AADC | activates | concept | 0.50 |
| PARKINSON'S | expressed_in | concept | 0.50 |
| ST3GAL2 | expressed_in | concept | 0.50 |
| GENE EXPRESSION | expressed_in | concept | 0.50 |
| Proteins | associated_with | protein | 0.50 |
| PREFRONTAL CORTEX | activates | concept | 0.50 |
| Microbiota | inhibits | process | 0.50 |
| Gut Microbiota | inhibits | process | 0.50 |
| HUNTINGTON'S | associated_with | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Parkinson's Disease | associated_with | disease | 0.95 |
| Tyrosine Hydroxylase | expressed_in | enzyme | 0.90 |
| Parkinson'S Disease | associated_with | disease | 0.90 |
| METTL3 | expressed_in | gene | 0.90 |
| MN | associated_with | compound | 0.90 |
| FE | associated_with | compound | 0.90 |
| LEPTIN | expressed_in | protein | 0.90 |
| PARK2 Deficiency | causes | phenotype | 0.88 |
| Reduced Gangliosides | biomarker_for | biomarker | 0.85 |
| MCH Neurons | expressed_in | cell_type | 0.85 |
| MCH | expressed_in | protein | 0.85 |
| TH | expressed_in | gene | 0.80 |
| REV-ERBα | expressed_in | protein | 0.80 |
| Dopamine | interacts_with | entity | 0.70 |
| GCASE | expressed_in | gene | 0.55 |
| NEURON | expressed_in | gene | 0.55 |
| PARKINSON'S DISEASE | expressed_in | gene | 0.55 |
| PARKINSON | expressed_in | gene | 0.55 |
| PLIN2 | expressed_in | gene | 0.55 |
| NEURODEGENERATION | expressed_in | gene | 0.55 |
| ALPHA-SYNUCLEIN | expressed_in | gene | 0.55 |
| AGING | expressed_in | gene | 0.55 |
| GBA | expressed_in | gene | 0.55 |
| RGS6 | expressed_in | gene | 0.55 |
| PSAP | expressed_in | gene | 0.55 |
| GPR37 | expressed_in | gene | 0.55 |
| NEUROINFLAMMATION | expressed_in | gene | 0.55 |
| IL-6 | expressed_in | gene | 0.55 |
| 6-OHDA | expressed_in | gene | 0.55 |
| FERROPORTIN | expressed_in | gene | 0.55 |
| DJ-1 | expressed_in | gene | 0.55 |
| VDR | expressed_in | gene | 0.55 |
| NLRP3 | expressed_in | gene | 0.55 |
| UBIQUITIN | expressed_in | gene | 0.55 |
| AIF1 | expressed_in | gene | 0.55 |
| SQSTM1 | expressed_in | gene | 0.55 |
| NEURODEGENERATIVE DISORDERS | expressed_in | gene | 0.55 |
| NEURODEGENERATIVE DISEASES | expressed_in | gene | 0.55 |
| GAPDH | expressed_in | gene | 0.55 |
| ACTB | expressed_in | gene | 0.55 |
| GFAP | expressed_in | gene | 0.55 |
| INFLAMMATION | expressed_in | gene | 0.55 |
| TNF | expressed_in | gene | 0.55 |
| ATG5 | expressed_in | gene | 0.55 |
| IL1B | expressed_in | gene | 0.55 |
| LC3B | expressed_in | gene | 0.55 |
| ASC | expressed_in | gene | 0.55 |
| GFP | expressed_in | gene | 0.55 |
| CASP1 | expressed_in | gene | 0.55 |
| SNCA | expressed_in | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||