gene

CD2AP GENE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD2AP GENE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

25Connections
0Hypotheses
0Analyses
17Outgoing
8Incoming

Summary

CD2AP is an adaptor protein involved in immune cell signaling, cytoskeletal organization, and endocytic trafficking. It is a significant risk gene for Alzheimer's disease.

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🧬 Gene Info
Gene SymbolCD2AP
Full NameCD2-Associated Protein
Chromosome6p12.3
Protein FamilySH3 domain-containing adaptor proteins
Functionis a scaffolding protein that plays critical roles in immune cell signaling, cytoskeletal organization, and receptor trafficking.
Primary Expressionthe brain, pa
Molecular Weight71 kDa
Amino Acids639 aa
Exons13
UniProt IDQ9Y5K7
NCBI Gene ID9501
Ensembl IDENSG00000198034
OMIM604332
GeneCardsCD2AP
Human Protein AtlasCD2AP
Associated DiseasesALS, Alzheimer
InteractionsCD2AP, ALZHEIMER
KG Connections25 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: CD2AP GENE — AlphaFold Q9Y5K7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

CD2AP Gene — CD2-Associated Protein

gene · 2828 words

EPHA1 Gene

gene · 2484 words

MS4A6A Gene

gene · 2260 words

Polygenic Risk Scores in Neurodegenerative Disease

mechanism · 1504 words

CD2AP Synaptic Dysfunction Alzheimer's Disease Causal Chain

mechanism · 1351 words

Pathway Diagram

graph TD
    CD2AP_GENE["<b>CD2AP GENE</b>"]
    ALS{"ALS"}
    CD2AP_GENE -->|"associated_with"| ALS
    Alzheimer{"Alzheimer"}
    CD2AP_GENE -->|"associated_with"| Alzheimer
    CD2AP_DEFICIENCY(["CD2AP DEFICIENCY"])
    CD2AP_GENE -->|"associated_with"| CD2AP_DEFICIENCY
    RNA(["RNA"])
    CD2AP_GENE -->|"associated_with"| RNA
    CD2AP(["CD2AP"])
    CD2AP_GENE -->|"associated_with"| CD2AP
    AND(["AND"])
    CD2AP_GENE -->|"associated_with"| AND
    ALZHEIMER_S_DISEASE(["ALZHEIMER'S DISEASE"])
    ALZHEIMER_S_DISEASE -->|"associated_with"| CD2AP_GENE
    ALZHEIMER(["ALZHEIMER"])
    ALZHEIMER -->|"associated_with"| CD2AP_GENE
    CSF1R(["CSF1R"])
    CSF1R -->|"associated_with"| CD2AP_GENE
    DISEASE_ASSOCIATED_MICROGLIA(["DISEASE-ASSOCIATED MICROGLIA"])
    DISEASE_ASSOCIATED_MICROGLIA -->|"associated_with"| CD2AP_GENE
    style CD2AP_GENE fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (17)

TargetRelationTypeStr
ALSassociated_withdisease0.65
Alzheimerassociated_withdisease0.65
CD2AP DEFICIENCYassociated_withgene0.60
RNAassociated_withgene0.60
CD2APassociated_withgene0.60

Incoming (8)

SourceRelationTypeStr
ALZHEIMER'S DISEASEassociated_withgene0.60
ALZHEIMERassociated_withgene0.60
CSF1Rassociated_withgene0.60
DISEASE-ASSOCIATED MICROGLIAassociated_withgene0.60
C1Qassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found