Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CD2AP GENE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CD2AP is an adaptor protein involved in immune cell signaling, cytoskeletal organization, and endocytic trafficking. It is a significant risk gene for Alzheimer's disease.
| Gene Symbol | CD2AP |
| Full Name | CD2-Associated Protein |
| Chromosome | 6p12.3 |
| Protein Family | SH3 domain-containing adaptor proteins |
| Function | is a scaffolding protein that plays critical roles in immune cell signaling, cytoskeletal organization, and receptor trafficking. |
| Primary Expression | the brain, pa |
| Molecular Weight | 71 kDa |
| Amino Acids | 639 aa |
| Exons | 13 |
| UniProt ID | Q9Y5K7 |
| NCBI Gene ID | 9501 |
| Ensembl ID | ENSG00000198034 |
| OMIM | 604332 |
| GeneCards | CD2AP |
| Human Protein Atlas | CD2AP |
| Associated Diseases | ALS, Alzheimer |
| Interactions | CD2AP, ALZHEIMER |
| KG Connections | 25 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CD2AP_GENE["<b>CD2AP GENE</b>"]
ALS{"ALS"}
CD2AP_GENE -->|"associated_with"| ALS
Alzheimer{"Alzheimer"}
CD2AP_GENE -->|"associated_with"| Alzheimer
CD2AP_DEFICIENCY(["CD2AP DEFICIENCY"])
CD2AP_GENE -->|"associated_with"| CD2AP_DEFICIENCY
RNA(["RNA"])
CD2AP_GENE -->|"associated_with"| RNA
CD2AP(["CD2AP"])
CD2AP_GENE -->|"associated_with"| CD2AP
AND(["AND"])
CD2AP_GENE -->|"associated_with"| AND
ALZHEIMER_S_DISEASE(["ALZHEIMER'S DISEASE"])
ALZHEIMER_S_DISEASE -->|"associated_with"| CD2AP_GENE
ALZHEIMER(["ALZHEIMER"])
ALZHEIMER -->|"associated_with"| CD2AP_GENE
CSF1R(["CSF1R"])
CSF1R -->|"associated_with"| CD2AP_GENE
DISEASE_ASSOCIATED_MICROGLIA(["DISEASE-ASSOCIATED MICROGLIA"])
DISEASE_ASSOCIATED_MICROGLIA -->|"associated_with"| CD2AP_GENE
style CD2AP_GENE fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8| Target | Relation | Type | Str |
|---|---|---|---|
| ALS | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| CD2AP DEFICIENCY | associated_with | gene | 0.60 |
| RNA | associated_with | gene | 0.60 |
| CD2AP | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| COMPLEMENT | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| Amyloid | associated_with | pathway | 0.60 |
| Phagocytosis | associated_with | pathway | 0.60 |
| Complement | associated_with | pathway | 0.60 |
| Microglia | expressed_in | cell_type | 0.55 |
| CD2AP | interacts_with | protein | 0.50 |
| ALZHEIMER | interacts_with | gene | 0.50 |
| Alzheimer'S Disease | interacts_with | disease | 0.50 |
| disease | interacts_with | disease | 0.50 |
| ALZHEIMER'S | interacts_with | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| CSF1R | associated_with | gene | 0.60 |
| DISEASE-ASSOCIATED MICROGLIA | associated_with | gene | 0.60 |
| C1Q | associated_with | gene | 0.60 |
| SYNAPSE | associated_with | gene | 0.60 |
| PHAGOCYTOSIS | associated_with | gene | 0.60 |
| MICROGLIA | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||