pathway

Phagocytosis

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Phagocytosis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3235Connections

5Hypotheses

0Analyses

48Outgoing

50Incoming

Summary

Phagocytosis is a biological pathway involved in neurodegeneration research. Key relationships include: activates, associated with, interacts with. Associated with ALS, Aging, Als. Connected to 655 entities in the SciDEX knowledge graph.

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🔀 Pathway Info

Name	Phagocytosis
Key Genes/Proteins	LC3, MICROGLIA, PHAGOCYTOSIS, CYTOKINES, INFLAMMATION, NEUROINFLAMMATION
Related Diseases	Als, Inflammation, Neuroinflammation, Cancer, Neurodegeneration
Linked Hypotheses	7 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Phagocytosis["Phagocytosis"] -->|"interacts"| Pyroptosis["Pyroptosis"]
    Microglia["Microglia"] -->|"activates"| Phagocytosis["Phagocytosis"]
    JUN["JUN"] -->|"protects against"| Phagocytosis["Phagocytosis"]
    APOE["APOE"] -->|"contributes to"| Phagocytosis["Phagocytosis"]
    RELN["RELN"] -->|"protects against"| Phagocytosis["Phagocytosis"]
    style Phagocytosis fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1264)

Target	Relation	Type	Str
Alzheimer's Disease Progression	involved_in	phenotype	0.85
Cognitive Resilience	contributes_to	phenotype	0.75
Pyroptosis	interacts_with	pathway	0.55
Microglia	activates	cell_type	0.50
Fibroblast	activates	cell_type	0.50
Macrophage	activates	cell_type	0.50
Neuron	activates	cell_type	0.50
Microglia	contributes_to	cell_type	0.50
Microglia	regulates	cell_type	0.50
Neuron	regulates	cell_type	0.50
Microglia	therapeutic_target	cell_type	0.50
Neuron	therapeutic_target	cell_type	0.50
Neutrophil	activates	cell_type	0.50
Macrophage	regulates	cell_type	0.50
Oligodendrocyte	activates	cell_type	0.50
Microglia	associated_with	cell_type	0.50
Neuron	associated_with	cell_type	0.50
Macrophage	associated_with	cell_type	0.50
T Cell	inhibits	cell_type	0.50
Astrocyte	activates	cell_type	0.50
T Cell	contributes_to	cell_type	0.50
Endothelial	interacts_with	cell_type	0.50
Stem Cell	activates	cell_type	0.50
Microglia	causes	cell_type	0.50
Astrocyte	causes	cell_type	0.50
Neuron	causes	cell_type	0.50
Microglia	interacts_with	cell_type	0.50
Neuron	protects_against	cell_type	0.50
Neuron	inhibits	cell_type	0.50
T Cell	therapeutic_target	cell_type	0.50
Microglia	expressed_in	cell_type	0.50
Microglia	protects_against	cell_type	0.50
Macrophage	inhibits	cell_type	0.50
Macrophage	interacts_with	cell_type	0.50
Microglia	inhibits	cell_type	0.50
T Cell	activates	cell_type	0.50
Endothelial	activates	cell_type	0.50
Macrophage	causes	cell_type	0.50
Neutrophil	causes	cell_type	0.50
Monocyte	activates	cell_type	0.50
Schwann Cell	associated_with	cell_type	0.50
Oligodendrocyte	causes	cell_type	0.50
Oligodendrocyte Precursor	causes	cell_type	0.50
Endothelial	associated_with	cell_type	0.50
Astrocyte	associated_with	cell_type	0.50
Macrophage	therapeutic_target	cell_type	0.50
Neuron	expressed_in	cell_type	0.50
Neuron	contributes_to	cell_type	0.50

Incoming (1971)

Source	Relation	Type	Str
Als	activates	disease	1.00
Inflammation	activates	disease	1.00
Neuroinflammation	activates	disease	1.00
Als	regulates	disease	1.00
Cancer	activates	disease	1.00
Neurodegeneration	activates	disease	1.00
LC3	associated_with	gene	1.00
Inflammation	regulates	disease	1.00
MICROGLIA	activates	gene	1.00
PHAGOCYTOSIS	activates	gene	1.00
CYTOKINES	activates	gene	1.00
INFLAMMATION	activates	gene	1.00
NEUROINFLAMMATION	activates	gene	1.00
PHAGOCYTOSIS	regulates	gene	1.00
PHAGOCYTOSIS	associated_with	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
INFLAMMATION	regulates	gene	1.00
CANCER	activates	gene	1.00
PHAGOCYTOSIS	implicated_in	gene	1.00
Als	implicated_in	disease	1.00
Inflammation	implicated_in	disease	1.00
Tumor	activates	disease	1.00
LC3	activates	gene	1.00
TREM2	activates	gene	1.00
Alzheimer	activates	disease	1.00
Als	associated_with	disease	1.00
AKT	activates	gene	1.00
MICROGLIA	regulates	gene	1.00
PHAGOCYTOSIS	inhibits	gene	1.00
COMPLEMENT	activates	gene	1.00
NEURODEGENERATION	activates	gene	1.00
ALZHEIMER	activates	gene	1.00
MICROGLIA	implicated_in	gene	1.00
INFLAMMATION	implicated_in	gene	1.00
NEURODEGENERATION	implicated_in	gene	1.00
Neurodegeneration	implicated_in	disease	1.00
Macrophages	involved_in	cell_type	0.95
Microglia	mediates	cell_type	0.95
Gastrodin	promotes	drug	0.95
Myeloid Cells	involved_in	cell_type	0.93
Microglia	involved_in	cell_type	0.90
MSR1	mediates	gene	0.90
TET2-Mutant Myeloid Cells	upregulates	cell_type	0.90
Myeloid Cells	mediates	cell_type	0.90
DAM	involved_in	cell_type	0.90
Cholecalciferol	associated_with	compound	0.90
ABCA7	regulates	protein	0.90
PPARA	activates	gene	0.90
C1Q	activates	gene	0.90
GENES	activates	gene	0.90

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SASP-Driven Microglial Metabolic Reprogramming in Synaptic P	0.638	neurodegeneration	Senolytic therapy for age-related neurod
TREM2-Dependent Microglial Phagocytosis Acts as a Strain Sel	0.636	neurodegeneration	What are the specific molecular determin
Stage-Selective TREM2 Agonism — Boosting DAM Phagocytosis in	0.458	Alzheimer's disease	TREM2 agonism vs antagonism in DAM micro
Soluble TREM2 (sTREM2) as Therapeutic Mimic — Decoupling Pha	0.452	Alzheimer's disease	TREM2 agonism vs antagonism in DAM micro
Microglial TREM2-Mediated Tau Phagocytosis Impairment	0.441	neuroscience	Circuit-level neural dynamics in neurode

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (18)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease [PMID:41109213]	Pilat DJ, Le H, Prokopenko D, Lin CJ, Ei	Neuron	2026
Role of TREM2 in neuroinflammation. [PMID:41213496]	Abdulkhaliq AA, Alasiri G, Almoghrabi Y,	Exp Neurol	2026
Synergistic potential of TREM2 agonists and exercise training in Alzheimer's dis [PMID:41494649]	Zhang J, St Pierre Schneider B, Muguerza	Am J Physiol Endocrinol Metab	2026
Diankuang Mengxing Decoction exerts neuroprotective effects in post-stroke depre [PMID:41534750]	Yang X, Zhao Y, Liu W, Feng J, Wu X et a	J Ethnopharmacol	2026
Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvir [PMID:41576929]	Mateus-Tique J, Lakshmi A, Singh B, Iyer	Cancer Cell	2026
Peripheral cancer attenuates amyloid pathology in Alzheimer's disease via cystat [PMID:41576952]	Li X, Tang X, Zeng J, Duan L, Hou Z et a	Cell	2026
TREM2 expression level is critical for microglial state, metabolic capacity and [PMID:41580393]	Feiten AF, Dahm K, Schlepckow K, van Len	Nat Commun	2026
Large-scale single-cell analysis and in silico perturbation reveal dynamic evolu [PMID:41617928]	Xia P, Shuang S, Fu D, Liu L, Yang D et	NPJ Precis Oncol	2026
Dissecting genetic and immune drivers of heterogeneous responses to neoadjuvant [PMID:41720086]	Zhao Q, Huang R, Wang C, Hu J, Nie R et	Cancer Cell	2026
TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604]	Yang HC, Deng YS, Zhang J, Zhang T, Song	J Alzheimers Dis	2026
Hierarchical Targeting of TREM2(+) Myeloid Cells via Acid-Triggered OMVs Reprogr [PMID:41945876]	Chen F, Xue Y, Ma X, Chen L, Shao Z et a	Adv Sci (Weinh)	2026
Correction to "A Strategy Involving Microporous Microneedles Integrated with CAR [PMID:41952643]	Unknown	Advanced materials (Deerfield	2026
TREM2 in neurodegeneration and diseases. [PMID:41792456]	["Abdulkhaliq A", "Alasiri G", "Kim B",	Molecular psychiatry	2026
Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721]	Aranda-Abreu GE, Rojas-Durán F, Hernánde	Neurology international	2026
Molecular mechanism of Alzheimer's disease using integrated multi-omics. [PMID:41907842]	Alhusaini M, Mussa BM, Ilce BY, Alhaj H,	Frontiers in aging neuroscienc	2026
Obesity-induced pyroptotic adipocyte death leads to TREM2-dependent macrophage d [PMID:41509917]	Choi C, Lee J, Park G, Namgoong S, Lee Y	iScience	2026
Viral and non-viral cellular therapies for neurodegeneration. [PMID:41585268]	["Srivastav Jyotsna", "Sharma Sachin"]	Frontiers in medicine	2025
Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy. [PMID:20301376]	Adam MP, Bick S, Mirzaa GM, Pagon RA, Wa		1993

Phagocytosis

Understanding Entity Pages

Summary

Wiki Pages (20)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Atypical Parkinsonism

nhp-validation-animal-model

Therapeutics

neuroinflammation

Microglial Cells — Cell Type Hierarchy

TREM2 Mechanism Hub

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

GSK-3β in Neurodegeneration

Growth Factor Therapies

Oligodendrocytes

Tau Spreading Mechanism

TREM2 Microglial Signaling Pathway in Neurodegeneration

dendritic-spines

DIAN-TU-001 Trial (NCT01760005)