COASY

Understanding Entity Pages

This page aggregates everything SciDEX knows about COASY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

COASY encodes Coenzyme A synthetase, a bifunctional enzyme in CoA biosynthesis. COASY mutations cause COASY Protein-Associated Neurodegeneration (CPAN), a form of NBIA with brain iron accumulation, dystonia, and cognitive decline.

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graph TD
    COASY["<b>COASY</b>"]
    Neurodegeneration{"Neurodegeneration"}
    COASY -->|"associated with"| Neurodegeneration
    Ms{"Ms"}
    COASY -->|"associated with"| Ms
    Parkinson{"Parkinson"}
    COASY -->|"associated with"| Parkinson
    Dystonia{"Dystonia"}
    COASY -->|"associated with"| Dystonia
    DCAF17["DCAF17"]
    COASY -->|"associated with"| DCAF17
    FA2H["FA2H"]
    COASY -->|"associated with"| FA2H
    C19ORF12["C19ORF12"]
    COASY -->|"associated with"| C19ORF12
    PANK2["PANK2"]
    COASY -->|"associated with"| PANK2
    PLA2G6["PLA2G6"]
    COASY -->|"associated with"| PLA2G6
    Lipid_Metabolism(["Lipid Metabolism"])
    COASY -->|"associated with"| Lipid_Metabolism
    Mitophagy(["Mitophagy"])
    COASY -->|"associated with"| Mitophagy
    Autophagy(["Autophagy"])
    COASY -->|"associated with"| Autophagy
    AKT["AKT"]
    AKT -->|"regulates"| COASY
    FTL["FTL"]
    FTL -->|"associated with"| COASY
    WDR45["WDR45"]
    WDR45 -->|"associated with"| COASY
    style COASY fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0