FTL

Understanding Entity Pages

This page aggregates everything SciDEX knows about FTL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

FTL encodes ferritin light chain, central to iron storage and antioxidant defense in the brain. Mutations cause neuroferritinopathy (NBIA), with relevance to Alzheimer's, Parkinson's, and other neurodegenerative diseases.

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graph TD
    FTL["<b>FTL</b>"]
    FERRITINLIGHTPROTEIN["FERRITINLIGHTPROTEIN"]
    FTL -->|"component of"| FERRITINLIGHTPROTEIN
    Neurodegeneration{"Neurodegeneration"}
    FTL -->|"associated with"| Neurodegeneration
    Ms{"Ms"}
    FTL -->|"associated with"| Ms
    Parkinson{"Parkinson"}
    FTL -->|"associated with"| Parkinson
    Dystonia{"Dystonia"}
    FTL -->|"associated with"| Dystonia
    Depression{"Depression"}
    FTL -->|"inhibits"| Depression
    Alzheimer{"Alzheimer"}
    FTL -->|"inhibits"| Alzheimer
    FTL -->|"inhibits"| Ms
    Als{"Als"}
    FTL -->|"associated with"| Als
    Leukemia{"Leukemia"}
    FTL -->|"associated with"| Leukemia
    WDR45["WDR45"]
    FTL -->|"associated with"| WDR45
    COASY["COASY"]
    FTL -->|"associated with"| COASY
    ACSL4["ACSL4"]
    ACSL4 -->|"expressed in"| FTL
    TFR1["TFR1"]
    TFR1 -->|"expressed in"| FTL
    APP["APP"]
    APP -->|"inhibits"| FTL
    GPX4["GPX4"]
    GPX4 -->|"expressed in"| FTL
    SLC7A11["SLC7A11"]
    SLC7A11 -->|"expressed in"| FTL
    NRF2["NRF2"]
    NRF2 -->|"expressed in"| FTL
    FTH1["FTH1"]
    FTH1 -->|"expressed in"| FTL
    ERK["ERK"]
    ERK -->|"associated with"| FTL
    JAK["JAK"]
    JAK -->|"associated with"| FTL
    LGALS3["LGALS3"]
    LGALS3 -->|"associated with"| FTL
    PI3K["PI3K"]
    PI3K -->|"associated with"| FTL
    FGF19["FGF19"]
    FGF19 -->|"associated with"| FTL
    style FTL fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0