Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about C19ORF12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
C19ORF12 is a protein involved in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Dystonia, Ms, Neurodegeneration. Connected to 15 entities in the SciDEX knowledge graph.
| Gene Symbol | C19ORF12 |
| Chromosome | 19q12 |
| Function | encodes a mitochondrial membrane protein that is highly expressed in the brain. |
| Subcellular Localization | C19orf12 localizes to: |
| Molecular Weight | 17 kDa |
| Amino Acids | 152 aa |
| Exons | 4 |
| Ensembl ID | ENSG00000131368 |
| GeneCards | C19ORF12 |
| Human Protein Atlas | C19ORF12 |
| Transmembrane domains | Two predicted transmembrane helices |
| Coiled-coil regions | Mediate protein-protein interactions |
| Lipid-binding domains | Interact with membrane lipids |
| Mitochondrial outer membrane | Primary location |
| Endoplasmic reticulum | Secondary localization in some cell types |
| Associated Diseases | Dystonia, Iron Accumulation, Ms, Neurodegeneration, Parkinson |
| KG Connections | 17 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
C19ORF12["<b>C19ORF12</b>"]
Neurodegeneration{"Neurodegeneration"}
C19ORF12 -->|"associated with"| Neurodegeneration
Ms{"Ms"}
C19ORF12 -->|"associated with"| Ms
Parkinson{"Parkinson"}
C19ORF12 -->|"associated with"| Parkinson
Dystonia{"Dystonia"}
C19ORF12 -->|"associated with"| Dystonia
PANK2["PANK2"]
C19ORF12 -->|"associated with"| PANK2
PLA2G6["PLA2G6"]
C19ORF12 -->|"associated with"| PLA2G6
Lipid_Metabolism(["Lipid Metabolism"])
C19ORF12 -->|"associated with"| Lipid_Metabolism
Mitophagy(["Mitophagy"])
C19ORF12 -->|"associated with"| Mitophagy
Autophagy(["Autophagy"])
C19ORF12 -->|"associated with"| Autophagy
neurodegeneration["neurodegeneration"]
C19ORF12 -->|"implicated in"| neurodegeneration
FTL["FTL"]
FTL -->|"associated with"| C19ORF12
WDR45["WDR45"]
WDR45 -->|"associated with"| C19ORF12
COASY["COASY"]
COASY -->|"associated with"| C19ORF12
DCAF17["DCAF17"]
DCAF17 -->|"associated with"| C19ORF12
FA2H["FA2H"]
FA2H -->|"associated with"| C19ORF12
style C19ORF12 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| AUTOPHAGY | modulates | process | 0.90 |
| Iron Accumulation | associated_with | phenotype | 0.85 |
| Lysosomal Acidification | regulates | process | 0.80 |
| Neurodegeneration | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Dystonia | associated_with | disease | 0.65 |
| PANK2 | associated_with | gene | 0.60 |
| PLA2G6 | associated_with | gene | 0.60 |
| Lipid Metabolism | associated_with | pathway | 0.60 |
| Mitophagy | associated_with | pathway | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||