protein

C19ORF12

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about C19ORF12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections
0Hypotheses
0Analyses
12Outgoing
5Incoming

Summary

C19ORF12 is a protein involved in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Dystonia, Ms, Neurodegeneration. Connected to 15 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolC19ORF12
Chromosome19q12
Functionencodes a mitochondrial membrane protein that is highly expressed in the brain.
Subcellular LocalizationC19orf12 localizes to:
Molecular Weight17 kDa
Amino Acids152 aa
Exons4
Ensembl IDENSG00000131368
GeneCardsC19ORF12
Human Protein AtlasC19ORF12
Transmembrane domainsTwo predicted transmembrane helices
Coiled-coil regionsMediate protein-protein interactions
Lipid-binding domainsInteract with membrane lipids
Mitochondrial outer membranePrimary location
Endoplasmic reticulumSecondary localization in some cell types
Associated DiseasesDystonia, Iron Accumulation, Ms, Neurodegeneration, Parkinson
KG Connections17 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

C19orf12 Gene - Chromosome 19 Open Reading Frame 12

gene · 2375 words

Pantothenate Kinase-Associated Neurodegeneration (PKAN)

disease · 2291 words

Globus Pallidus

brain · 2130 words

Pantothenate Kinase-Associated Neurodegeneration (PKAN)

disease · 1886 words

Mitochondrial Membrane Protein-Associated Neurodegeneration (MPAN)

disease · 1665 words

Dystonia

disease · 1513 words

Pathway Diagram

graph TD
    C19ORF12["<b>C19ORF12</b>"]
    Neurodegeneration{"Neurodegeneration"}
    C19ORF12 -->|"associated with"| Neurodegeneration
    Ms{"Ms"}
    C19ORF12 -->|"associated with"| Ms
    Parkinson{"Parkinson"}
    C19ORF12 -->|"associated with"| Parkinson
    Dystonia{"Dystonia"}
    C19ORF12 -->|"associated with"| Dystonia
    PANK2["PANK2"]
    C19ORF12 -->|"associated with"| PANK2
    PLA2G6["PLA2G6"]
    C19ORF12 -->|"associated with"| PLA2G6
    Lipid_Metabolism(["Lipid Metabolism"])
    C19ORF12 -->|"associated with"| Lipid_Metabolism
    Mitophagy(["Mitophagy"])
    C19ORF12 -->|"associated with"| Mitophagy
    Autophagy(["Autophagy"])
    C19ORF12 -->|"associated with"| Autophagy
    neurodegeneration["neurodegeneration"]
    C19ORF12 -->|"implicated in"| neurodegeneration
    FTL["FTL"]
    FTL -->|"associated with"| C19ORF12
    WDR45["WDR45"]
    WDR45 -->|"associated with"| C19ORF12
    COASY["COASY"]
    COASY -->|"associated with"| C19ORF12
    DCAF17["DCAF17"]
    DCAF17 -->|"associated with"| C19ORF12
    FA2H["FA2H"]
    FA2H -->|"associated with"| C19ORF12
    style C19ORF12 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (12)

TargetRelationTypeStr
AUTOPHAGYmodulatesprocess0.90
Iron Accumulationassociated_withphenotype0.85
Lysosomal Acidificationregulatesprocess0.80
Neurodegenerationassociated_withdisease0.65
Msassociated_withdisease0.65

Incoming (5)

SourceRelationTypeStr
FTLassociated_withgene0.60
WDR45associated_withgene0.60
COASYassociated_withgene0.60
DCAF17associated_withgene0.60
FA2Hassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found