Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DCAF17: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DCAF17 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Dystonia, Ms, Neurodegeneration. Connected to 15 entities in the SciDEX knowledge graph.
| Gene Symbol | DCAF17 |
| Full Name | DDB1 and CUL4 Associated Factor 17 |
| Chromosome | 2q31.1 |
| Protein Type | Receptor |
| Function | encodes a substrate receptor component of the CUL4-DDB1 ubiquitin ligase complex. |
| Primary Expression | endocrine tissues and the brain, where pathogenic variants cause Woodhouse-Sakati syndrome (WSS), a rare autosomal recessive disorder characterized by |
| Subcellular Localization | DCAF17 localizes primarily to the: |
| Amino Acids | 459 aa |
| Exons | 10 |
| Ensembl ID | ENSG00000056678 |
| GeneCards | DCAF17 |
| Human Protein Atlas | DCAF17 |
| DWD box | The "DDB1-WD40" motif is required for interaction with DDB1 |
| H-box | A conserved histidine-containing motif involved in substrate recognition |
| C-terminal domain | Mediates dimerization and complex assembly |
| Associated Diseases | ALS, Dystonia, Ms, Neurodegeneration, Parkinson |
| Interactions | UBIQUITIN, PINK1, H2AX, P62, SNCA, DCTN5 |
| KG Connections | 60 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
DCAF17["<b>DCAF17</b>"]
Neurodegeneration{"Neurodegeneration"}
DCAF17 -->|"associated with"| Neurodegeneration
Ms{"Ms"}
DCAF17 -->|"associated with"| Ms
Parkinson{"Parkinson"}
DCAF17 -->|"associated with"| Parkinson
Dystonia{"Dystonia"}
DCAF17 -->|"associated with"| Dystonia
FA2H["FA2H"]
DCAF17 -->|"associated with"| FA2H
C19ORF12["C19ORF12"]
DCAF17 -->|"associated with"| C19ORF12
PANK2["PANK2"]
DCAF17 -->|"associated with"| PANK2
PLA2G6["PLA2G6"]
DCAF17 -->|"associated with"| PLA2G6
Lipid_Metabolism(["Lipid Metabolism"])
DCAF17 -->|"associated with"| Lipid_Metabolism
Mitophagy(["Mitophagy"])
DCAF17 -->|"associated with"| Mitophagy
Autophagy(["Autophagy"])
DCAF17 -->|"associated with"| Autophagy
neurodegeneration["neurodegeneration"]
DCAF17 -->|"implicated in"| neurodegeneration
FTL["FTL"]
FTL -->|"associated with"| DCAF17
WDR45["WDR45"]
WDR45 -->|"associated with"| DCAF17
COASY["COASY"]
COASY -->|"associated with"| DCAF17
style DCAF17 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Neurodegeneration | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Dystonia | associated_with | disease | 0.65 |
| Neurodegeneration | inhibits | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Parkinson | inhibits | disease | 0.65 |
| Parkinson | causes | disease | 0.65 |
| ALS | causes | disease | 0.65 |
| Neurodegeneration | causes | disease | 0.65 |
| FA2H | associated_with | gene | 0.60 |
| C19ORF12 | associated_with | gene | 0.60 |
| PANK2 | associated_with | gene | 0.60 |
| PLA2G6 | associated_with | gene | 0.60 |
| UBIQUITIN | inhibits | gene | 0.60 |
| PINK1 | inhibits | gene | 0.60 |
| H2AX | inhibits | gene | 0.60 |
| P62 | inhibits | gene | 0.60 |
| SNCA | activates | gene | 0.60 |
| PINK1 | causes | gene | 0.60 |
| UBIQUITIN | causes | gene | 0.60 |
| DCTN5 | activates | gene | 0.60 |
| DAPK1 | activates | gene | 0.60 |
| P62 | causes | gene | 0.60 |
| FA2H | interacts_with | gene | 0.60 |
| FTL | interacts_with | gene | 0.60 |
| PANK2 | interacts_with | gene | 0.60 |
| PLA2G6 | interacts_with | gene | 0.60 |
| WDR45 | interacts_with | gene | 0.60 |
| neurodegeneration | interacts_with | disease | 0.60 |
| Lipid Metabolism | associated_with | pathway | 0.60 |
| Mitophagy | associated_with | pathway | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| PARKINSON | inhibits | gene | 0.60 |
| Mitophagy | inhibits | pathway | 0.60 |
| PARKINSON | causes | gene | 0.60 |
| AND | activates | gene | 0.60 |
| MITOPHAGY | causes | gene | 0.60 |
| PARKINSON'S DISEASE | causes | gene | 0.60 |
| ALPHA-SYNUCLEIN | causes | gene | 0.60 |
| Alpha-Synuclein | causes | pathway | 0.60 |
| Mitophagy | causes | pathway | 0.60 |
| MITOPHAGY | inhibits | gene | 0.60 |
| Alpha-Synuclein | inhibits | protein | 0.60 |
| Ras | inhibits | protein | 0.60 |
| Spinal Cord | expressed_in | brain_region | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| FTL | associated_with | gene | 0.60 |
| WDR45 | associated_with | gene | 0.60 |
| COASY | associated_with | gene | 0.60 |
| DAPK1 | activates | gene | 0.60 |
| DCTN5 | activates | gene | 0.60 |
| H2AX | causes | gene | 0.60 |
| P62 | inhibits | gene | 0.60 |
| ATP13A2 | interacts_with | gene | 0.60 |
| CP | interacts_with | gene | 0.60 |
| MITOPHAGY | inhibits | gene | 0.60 |
| NEURODEGENERATION | causes | gene | 0.60 |
| DNA | causes | gene | 0.60 |
| NEUROTOXICITY | causes | gene | 0.60 |
| SNCA | activates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||