gene

DCAF17

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DCAF17: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

60Connections
0Hypotheses
0Analyses
46Outgoing
14Incoming

Summary

DCAF17 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Dystonia, Ms, Neurodegeneration. Connected to 15 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolDCAF17
Full NameDDB1 and CUL4 Associated Factor 17
Chromosome2q31.1
Protein TypeReceptor
Functionencodes a substrate receptor component of the CUL4-DDB1 ubiquitin ligase complex.
Primary Expressionendocrine tissues and the brain, where pathogenic variants cause Woodhouse-Sakati syndrome (WSS), a rare autosomal recessive disorder characterized by
Subcellular LocalizationDCAF17 localizes primarily to the:
Amino Acids459 aa
Exons10
Ensembl IDENSG00000056678
GeneCardsDCAF17
Human Protein AtlasDCAF17
DWD boxThe "DDB1-WD40" motif is required for interaction with DDB1
H-boxA conserved histidine-containing motif involved in substrate recognition
C-terminal domainMediates dimerization and complex assembly
Associated DiseasesALS, Dystonia, Ms, Neurodegeneration, Parkinson
InteractionsUBIQUITIN, PINK1, H2AX, P62, SNCA, DCTN5
KG Connections60 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

DCAF17 Gene - DDB1 and CUL4 Associated Factor 17

gene · 2411 words

Dystonia

disease · 1513 words

Woodhouse-Sakati Syndrome (WSS)

disease · 979 words

CP Gene - Ceruloplasmin

gene · 862 words

DCTN5 Gene

gene · 778 words

Genes

index · 271 words

Pathway Diagram

graph TD
    DCAF17["<b>DCAF17</b>"]
    Neurodegeneration{"Neurodegeneration"}
    DCAF17 -->|"associated with"| Neurodegeneration
    Ms{"Ms"}
    DCAF17 -->|"associated with"| Ms
    Parkinson{"Parkinson"}
    DCAF17 -->|"associated with"| Parkinson
    Dystonia{"Dystonia"}
    DCAF17 -->|"associated with"| Dystonia
    FA2H["FA2H"]
    DCAF17 -->|"associated with"| FA2H
    C19ORF12["C19ORF12"]
    DCAF17 -->|"associated with"| C19ORF12
    PANK2["PANK2"]
    DCAF17 -->|"associated with"| PANK2
    PLA2G6["PLA2G6"]
    DCAF17 -->|"associated with"| PLA2G6
    Lipid_Metabolism(["Lipid Metabolism"])
    DCAF17 -->|"associated with"| Lipid_Metabolism
    Mitophagy(["Mitophagy"])
    DCAF17 -->|"associated with"| Mitophagy
    Autophagy(["Autophagy"])
    DCAF17 -->|"associated with"| Autophagy
    neurodegeneration["neurodegeneration"]
    DCAF17 -->|"implicated in"| neurodegeneration
    FTL["FTL"]
    FTL -->|"associated with"| DCAF17
    WDR45["WDR45"]
    WDR45 -->|"associated with"| DCAF17
    COASY["COASY"]
    COASY -->|"associated with"| DCAF17
    style DCAF17 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (46)

TargetRelationTypeStr
Neurodegenerationassociated_withdisease0.65
Msassociated_withdisease0.65
Parkinsonassociated_withdisease0.65
Dystoniaassociated_withdisease0.65
Neurodegenerationinhibitsdisease0.65

Incoming (14)

SourceRelationTypeStr
FTLassociated_withgene0.60
WDR45associated_withgene0.60
COASYassociated_withgene0.60
DAPK1activatesgene0.60
DCTN5activatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found