gene

CPLX2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CPLX2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections
0Hypotheses
0Analyses
13Outgoing
2Incoming

Summary

CPLX2 — Complexin 2

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🧬 Gene Info
Gene SymbolCPLX2
Full NameComplexin 2
Chromosome5q31.2
FunctionComplexin 2 is a cytosolic protein that regulates SNARE complex assembly
Amino Acids150 aa
UniProt IDO75178
NCBI Gene ID10857
Ensembl IDENSG00000128487
OMIM605738
GeneCardsCPLX2
Human Protein AtlasCPLX2
DiseaseMechanism
[Alzheimer's Disease](/diseases/alzheimers-disease)CPLX2 levels reduced in AD hippocampus; involved in synaptic dysfunction
[Parkinson's Disease](/diseases/parkinsons-disease)Altered SNARE regulation affects dopaminergic transmission
EpilepsyMutations affect release probability and seizure threshold
Associated DiseasesAlzheimer, neurodegeneration
InteractionsDNM1L, ICAM1, PINK1, TFAM, TNF, BDNF
KG Connections15 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: CPLX2 — AlphaFold O75178 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

CPLX2 — Complexin 2

gene · 917 words

syt10

gene · 2829 words

Lateral Hypothalamus

cell_type · 2514 words

Complexin-2 Protein

protein · 1422 words

SNARE Complex Neurons

cell · 1305 words

Foxp1 Neurons

cell · 1202 words

Pathway Diagram

flowchart TD
    N0["CPLX2"]
    N1["neurodegeneration"]
    N0 -->|"associated with"| N1
    N2["Alzheimer"]
    N0 -->|"associated with"| N2
    N3["DNM1L"]
    N0 -->|"co expressed with"| N3
    N4["GPX1"]
    N0 -->|"co expressed with"| N4
    N5["BDNF"]
    N5 -->|"co expressed with"| N0
    N0 -->|"implicated in"| N1

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 gene
    class N4 gene
    class N5 gene

Outgoing (13)

TargetRelationTypeStr
synaptic plasticityinvolved_inprocess0.80
synaptic transmissioninvolved_inprocess0.75
neurodegenerationassociated_withdisease0.60
DNM1Lactivatesgene0.60
ICAM1activatesgene0.60

Incoming (2)

SourceRelationTypeStr
BDNFactivatesgene0.60
BDNFco_expressed_withgene0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found