Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CPLX2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | CPLX2 |
| Full Name | Complexin 2 |
| Chromosome | 5q31.2 |
| Function | Complexin 2 is a cytosolic protein that regulates SNARE complex assembly |
| Amino Acids | 150 aa |
| UniProt ID | O75178 |
| NCBI Gene ID | 10857 |
| Ensembl ID | ENSG00000128487 |
| OMIM | 605738 |
| GeneCards | CPLX2 |
| Human Protein Atlas | CPLX2 |
| Disease | Mechanism |
| [Alzheimer's Disease](/diseases/alzheimers-disease) | CPLX2 levels reduced in AD hippocampus; involved in synaptic dysfunction |
| [Parkinson's Disease](/diseases/parkinsons-disease) | Altered SNARE regulation affects dopaminergic transmission |
| Epilepsy | Mutations affect release probability and seizure threshold |
| Associated Diseases | Alzheimer, neurodegeneration |
| Interactions | DNM1L, ICAM1, PINK1, TFAM, TNF, BDNF |
| KG Connections | 15 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["CPLX2"]
N1["neurodegeneration"]
N0 -->|"associated with"| N1
N2["Alzheimer"]
N0 -->|"associated with"| N2
N3["DNM1L"]
N0 -->|"co expressed with"| N3
N4["GPX1"]
N0 -->|"co expressed with"| N4
N5["BDNF"]
N5 -->|"co expressed with"| N0
N0 -->|"implicated in"| N1
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease
class N2 disease
class N3 gene
class N4 gene
class N5 gene| Target | Relation | Type | Str |
|---|---|---|---|
| synaptic plasticity | involved_in | process | 0.80 |
| synaptic transmission | involved_in | process | 0.75 |
| neurodegeneration | associated_with | disease | 0.60 |
| DNM1L | activates | gene | 0.60 |
| ICAM1 | activates | gene | 0.60 |
| PINK1 | activates | gene | 0.60 |
| TFAM | activates | gene | 0.60 |
| TNF | activates | gene | 0.60 |
| Alzheimer | associated_with | disease | 0.60 |
| mitochondrial function | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| DNM1L | co_expressed_with | gene | 0.50 |
| GPX1 | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||