gene

GPX1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GPX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

166Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

GPX1 is a gene implicated in neurodegeneration research. Key relationships include: activates, expressed in, associated with. Associated with Aging, Als, Alzheimer. Connected to 85 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GPX1
Full Name	Glutathione Peroxidase 1
Chromosome	3p21.31
Protein Type	Selenoprotein, Antioxidant enzyme
Function	is a gene located on chromosome 3p21.
Molecular Weight	22.5 kDa
Amino Acids	203 aa
Exons	2
Pathways	Epigenetic, Mitochondrial Function, Oxidative Stress
UniProt ID	P07203
NCBI Gene ID	2783
Ensembl ID	ENSG00000133247
OMIM	138320
GeneCards	GPX1
Human Protein Atlas	GPX1
Associated Diseases	Als, Alzheimer, ALZHEIMER'S DISEASE, Inflammation, Ms
Interactions	AGING, ALZHEIMER'S DISEASE, AND, ANTIOXIDANT GENES, APOPTOSIS, APP
KG Connections	166 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GPX1 — AlphaFold P07203 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

GPX1 — Glutathione Peroxidase 1

gene · 2009 words

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GPX1 Protein

protein · 663 words

→

Pathway Diagram

graph TD
    GPX1["<b>GPX1</b>"]
    Cancer{"Cancer"}
    GPX1 -->|"activates"| Cancer
    Tumor{"Tumor"}
    GPX1 -->|"activates"| Tumor
    Alzheimer{"Alzheimer"}
    GPX1 -->|"activates"| Alzheimer
    Huntington{"Huntington"}
    GPX1 -->|"activates"| Huntington
    Atherosclerosis{"Atherosclerosis"}
    GPX1 -->|"activates"| Atherosclerosis
    Diabetes{"Diabetes"}
    GPX1 -->|"activates"| Diabetes
    Senescence{"Senescence"}
    GPX1 -->|"activates"| Senescence
    Als{"Als"}
    GPX1 -->|"activates"| Als
    Ms{"Ms"}
    GPX1 -->|"activates"| Ms
    GPX1 -->|"interacts with"| Als
    GPX1 -->|"associated with"| Ms
    GPX1 -->|"interacts with"| Cancer
    BAX["BAX"]
    BAX -->|"expressed in"| GPX1
    P53["P53"]
    P53 -->|"expressed in"| GPX1
    SOD2["SOD2"]
    SOD2 -->|"activates"| GPX1
    STAR["STAR"]
    STAR -->|"activates"| GPX1
    CAT["CAT"]
    CAT -->|"activates"| GPX1
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"activates"| GPX1
    ERK["ERK"]
    ERK -->|"associated with"| GPX1
    PPARA["PPARA"]
    PPARA -->|"associated with"| GPX1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"activates"| GPX1
    P53 -->|"associated with"| GPX1
    SOD2 -->|"associated with"| GPX1
    NOX4["NOX4"]
    NOX4 -->|"activates"| GPX1
    style GPX1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (92)

Target	Relation	Type	Str
Oxidative Stress	protects_against	process	0.85
ALZHEIMER'S DISEASE	associated_with	disease	0.85
Als	activates	disease	0.75
Oxidative Stress	activates	pathway	0.70
ROS	biomarker_for	gene	0.70
Inflammation	activates	disease	0.65
Aging	activates	disease	0.65
Inflammation	causes	disease	0.65
Senescence	activates	disease	0.65
Ms	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Diabetes	activates	disease	0.65
ALS	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Als	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Dementia	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
ALS	inhibits	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Diabetes	inhibits	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Huntington	activates	disease	0.65
Alzheimer	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Ms	associated_with	disease	0.65
Cancer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
MTOR	activates	gene	0.60
ABCA1	regulates	gene	0.60
PRKAA1	binds_to	gene	0.60
SIRT1	binds_to	gene	0.60
neurodegeneration	associated_with	disease	0.60
BCL-2	activates	gene	0.60
Apoptosis	activates	pathway	0.60
Alzheimer	associated_with	disease	0.60
NRF2	activates	gene	0.60
GPX4	interacts_with	gene	0.60
Nf-Κb	expressed_in	pathway	0.60
PPARG	associated_with	gene	0.60
Dna Repair	activates	pathway	0.60
Mtor	activates	pathway	0.60
Mitophagy	activates	pathway	0.60
endothelial cells	expressed_in	cell_type	0.60
TNF	causes	gene	0.60

Incoming (74)

Source	Relation	Type	Str
OXIDATIVE STRESS	activates	gene	0.70
CRLS1	interacts_with	gene	0.60
P53	expressed_in	gene	0.60
APOPTOSIS	activates	gene	0.60
CYP2E1	interacts_with	gene	0.60
NRF2	activates	gene	0.60
ANTIOXIDANT GENES	activates	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
OXIDATIVE STRESS	expressed_in	gene	0.60
BAX	expressed_in	gene	0.60
SOD2	activates	gene	0.60
STAR	activates	gene	0.60
CAT	activates	gene	0.60
PPARA	associated_with	gene	0.60
SOD2	associated_with	gene	0.60
NOX4	activates	gene	0.60
SOD1	activates	gene	0.60
SOD2	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
GFAP	activates	gene	0.60
SIRT1	associated_with	gene	0.60
PRDX5	associated_with	gene	0.60
PRKAA1	associated_with	gene	0.60
APP	associated_with	gene	0.60
KEAP1	associated_with	gene	0.60
ERK	associated_with	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
P53	associated_with	gene	0.60
AND	activates	gene	0.60
GENES	activates	gene	0.60
HIF	activates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
NRF2	regulates	gene	0.60
ANTIOXIDANT GENES	associated_with	gene	0.60
CANCER	interacts_with	gene	0.60
INFLAMMATION	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
NF-ΚB	expressed_in	gene	0.60
TNF-Α	expressed_in	gene	0.60
AGING	activates	gene	0.60
DNA	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
EXERCISE	activates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
AKT	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
APP	interacts_with	gene	0.60
GRN	activates	gene	0.60
FAM171A2	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity