pathway

Synaptic Transmission

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Synaptic Transmission: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

248Connections

1Hypotheses

2Analyses

15Outgoing

50Incoming

0Experiments

3Debates

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🔀 Pathway Info

Name	Synaptic Transmission
Key Genes/Proteins	ACHE, ALPHA-SYNUCLEIN, ALZHEIMER, ALZHEIMER'S DISEASE, AMPA RECEPTOR, AMYLOID
Related Diseases	Aging, Als, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis
Linked Hypotheses	1 hypotheses

Wiki Pages (1)

Knowledge base pages for this entity

Synaptic Transmission

mechanism · 2440 words

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Pathway Diagram

graph TD
    MIRO1["MIRO1"] -->|"therapeutic target"| Synaptic_Transmission["Synaptic Transmission"]
    ERK["ERK"] -.->|"inhibits"| Synaptic_Transmission["Synaptic Transmission"]
    GAP43["GAP43"] -->|"interacts"| Synaptic_Transmission["Synaptic Transmission"]
    ERBB4["ERBB4"] -->|"activates"| Synaptic_Transmission["Synaptic Transmission"]
    style Synaptic_Transmission fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (15)

Target	Relation	Type	Str
NEURONS	treats	cell_type	0.65
CA1	associated_with	brain_region	0.50
CA3	associated_with	brain_region	0.50
RETINA	associated_with	brain_region	0.50
GLUTAMATE	regulates	concept	0.50
PREFRONTAL CORTEX	activates	concept	0.50
INTERNEURONS	activates	concept	0.50
CELL SURVIVAL	regulates	concept	0.50
Proteins	associated_with	protein	0.50
Proteins	activates	protein	0.50
Proteins	interacts_with	protein	0.50
Proteins	regulates	protein	0.50
HIPPOCAMPUS	associated_with	brain_region	0.50
PREFRONTAL CORTEX	associated_with	brain_region	0.45
CORTEX	associated_with	brain_region	0.45

Incoming (233)

Source	Relation	Type	Str
Chr2	inhibits	protein	0.95
Cytoskeleton	regulates	pathway	0.90
Purinergic Receptor Type 2	mediates	receptor	0.90
CNR1	regulates	protein	0.90
Astrocytes	modulates	cell_type	0.90
Astrocytes	regulates	cell_type	0.90
BDNF	modulates	protein	0.90
Calcium Homeostasis	regulates	process	0.90
Astrocytes	mediates	cell_type	0.85
LRRK2	associated_with	gene	0.85
Alzheimer'S Disease	associated_with	disease	0.85
Gaba-B Receptor	regulates	receptor	0.85
SNCA	involved_in	gene	0.85
BIN1	modulates	gene	0.85
NPY	involved_in	gene	0.85
PINK1	regulates	gene	0.80
DLG4	involved_in	protein	0.80
BDNF	enhances	gene	0.80
CPLX2	involved_in	gene	0.75
BIN1	associated_with	protein	0.75
BRD4	regulates	gene	0.70
BDNF	regulates	gene	0.70
EZH2	inhibits	enzyme	0.70
C9orf72 ASO	restores	drug	0.70
C9orf72 ASO	regulates	drug	0.70
BIN1	regulates	gene	0.65
TAU	regulates	protein	0.65
BIN1	transports	gene	0.65
AND	regulates	gene	0.60
ALZHEIMER'S	regulates	disease	0.60
AMYOTROPHIC LATERAL SCLEROSIS	regulates	disease	0.60
PARKINSON'S	regulates	disease	0.60
ALZHEIMER	causes	disease	0.60
ASTROCYTES	regulates	gene	0.60
ASTROCYTE	regulates	gene	0.60
OGT	regulates	gene	0.60
DEPRESSION	regulates	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
C-JUN	inhibits	gene	0.60
JUN	inhibits	gene	0.60
APP	inhibits	gene	0.60
TAU	inhibits	gene	0.60
MAPK	inhibits	gene	0.60
JNK	inhibits	gene	0.60
HDAC6	inhibits	gene	0.60
TAU PATHOLOGY	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Pharmacological EZH2 Inhibition Resets Polycomb-Mediated Rep	0.680	neurodegeneration	epigenetic reprogramming aging neurons

Mentioning Analyses (2)

Scientific analyses that reference this entity

How can circuit-level neurodegeneration mechanisms be identified without complet

research methodology | 2026-04-11 | 0 hypotheses

Investigate mechanisms of epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-10 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Investigate mechanisms of epigenetic reprogramming in aging neurons [TARGET_ART

closed · Rounds: 0 · Score: 0.50 · 2026-04-21

Investigate mechanisms of epigenetic reprogramming in aging neurons

closed · Rounds: 0 · Score: 0.56 · 2026-04-21

The debate transcript shows incomplete analysis where the Theorist reached maxim

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning Synaptic Transmission in their description or question text

No additional research found