Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Synaptic Transmission: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | Synaptic Transmission |
| Key Genes/Proteins | Chr2, BDNF, LRRK2, SNCA, BIN1, NPY |
| Related Diseases | Alzheimer'S Disease |
| Related Pathways | Cytoskeleton |
Knowledge base pages for this entity
graph TD
MIRO1["MIRO1"] -->|"therapeutic target"| Synaptic_Transmission["Synaptic Transmission"]
ERK["ERK"] -.->|"inhibits"| Synaptic_Transmission["Synaptic Transmission"]
GAP43["GAP43"] -->|"interacts"| Synaptic_Transmission["Synaptic Transmission"]
ERBB4["ERBB4"] -->|"activates"| Synaptic_Transmission["Synaptic Transmission"]
style Synaptic_Transmission fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| CELL SURVIVAL | regulates | concept | 0.50 |
| GLUTAMATE | regulates | concept | 0.50 |
| PREFRONTAL CORTEX | activates | concept | 0.50 |
| INTERNEURONS | activates | concept | 0.50 |
| Proteins | associated_with | protein | 0.50 |
| Proteins | activates | protein | 0.50 |
| Proteins | interacts_with | protein | 0.50 |
| Proteins | regulates | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Chr2 | inhibits | protein | 0.95 |
| Astrocytes | modulates | cell_type | 0.90 |
| Astrocytes | regulates | cell_type | 0.90 |
| Calcium Homeostasis | regulates | process | 0.90 |
| Purinergic Receptor Type 2 | mediates | receptor | 0.90 |
| BDNF | modulates | protein | 0.90 |
| Cytoskeleton | regulates | pathway | 0.90 |
| Astrocytes | mediates | cell_type | 0.85 |
| LRRK2 | involved_in | gene | 0.85 |
| SNCA | involved_in | gene | 0.85 |
| Gaba-B Receptor | regulates | receptor | 0.85 |
| Alzheimer'S Disease | associated_with | disease | 0.85 |
| BIN1 | modulates | gene | 0.85 |
| NPY | involved_in | gene | 0.85 |
| MIRO1 | therapeutic_target | gene | 0.60 |
| ERK | inhibits | gene | 0.60 |
| GAP43 | interacts_with | gene | 0.60 |
| ERBB4 | activates | gene | 0.60 |
| NRG1 | activates | gene | 0.60 |
| BCL-2 | regulates | gene | 0.60 |
| PRESENILIN | regulates | gene | 0.60 |
| GFAP | regulates | gene | 0.60 |
| TNF | regulates | gene | 0.60 |
| TNFR1 | regulates | gene | 0.60 |
| TNFR2 | regulates | gene | 0.60 |
| ASTROCYTES | regulates | gene | 0.60 |
| ASTROCYTE | regulates | gene | 0.60 |
| OGT | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| DEPRESSION | regulates | gene | 0.60 |
| MICROGLIA | inhibits | gene | 0.60 |
| NEURON | inhibits | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| EPILEPSY | inhibits | gene | 0.60 |
| PARKINSON'S DISEASE | regulates | gene | 0.60 |
| LRRK2 | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| NEURODEGENERATION | associated_with | gene | 0.60 |
| PARKINSON | regulates | gene | 0.60 |
| ALPHA-SYNUCLEIN | associated_with | gene | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
| TP53 | therapeutic_target | gene | 0.60 |
| CALM1 | therapeutic_target | gene | 0.60 |
| HRAS | therapeutic_target | gene | 0.60 |
| CIRCADIAN RHYTHM | regulates | gene | 0.60 |
| ACHE | therapeutic_target | gene | 0.60 |
| IL1B | therapeutic_target | gene | 0.60 |
| GENES | therapeutic_target | gene | 0.60 |
| IDH1 | therapeutic_target | gene | 0.60 |
| KCNQ1 | therapeutic_target | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||