Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DNAJB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Gene profile: DNAJB2 (DNAJ Heat Shock Protein Family Member B2) - co-chaperone involved in protein quality control and neurodegeneration
| Gene Symbol | DNAJB2 |
| Full Name | DNAJ Heat Shock Protein Family Member B2 |
| Chromosome | 2q32.2 |
| Protein Type | Chaperone |
| Function | is a critical co-chaperone protein that plays essential roles in protein quality control within neuronal cells. |
| Primary Expression | Brain, spinal cord, peripheral nerves |
| Molecular Weight | 35 kDa |
| Amino Acids | 324 aa |
| UniProt ID | Q9UPE1 |
| NCBI Gene ID | 7261 |
| Ensembl ID | ENSG00000105971 |
| OMIM | 604260 |
| GeneCards | DNAJB2 |
| Human Protein Atlas | DNAJB2 |
| HSPA1A/Hsp70-1A | Cytosolic Hsp70 involved in general protein folding |
| Associated Diseases | neurodegeneration |
| Interactions | DNAJB1, DNAJA1, HSP70, DNAJB6, PARKINSON, ALZHEIMER |
| KG Connections | 47 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
DNAJB2["<b>DNAJB2</b>"]
Alzheimer["Alzheimer"]
DNAJB2 -->|"inhibits"| Alzheimer
Huntington["Huntington"]
DNAJB2 -->|"inhibits"| Huntington
Parkinson["Parkinson"]
DNAJB2 -->|"inhibits"| Parkinson
Spinocerebellar_Ataxia["Spinocerebellar Ataxia"]
DNAJB2 -->|"inhibits"| Spinocerebellar_Ataxia
Ataxia["Ataxia"]
DNAJB2 -->|"inhibits"| Ataxia
Neuropathy["Neuropathy"]
DNAJB2 -->|"inhibits"| Neuropathy
PARKINSON["PARKINSON"]
DNAJB2 -->|"inhibits"| PARKINSON
Neuron["Neuron"]
DNAJB2 -->|"inhibits"| Neuron
ALZHEIMER["ALZHEIMER"]
DNAJB2 -->|"inhibits"| ALZHEIMER
HUNTINGTON_S_DISEASE["HUNTINGTON'S DISEASE"]
DNAJB2 -->|"inhibits"| HUNTINGTON_S_DISEASE
NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
DNAJB2 -->|"inhibits"| NEURODEGENERATIVE_DISEASES
HUNTINGTON["HUNTINGTON"]
DNAJB2 -->|"inhibits"| HUNTINGTON
AND["AND"]
DNAJB2 -->|"inhibits"| AND
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
DNAJB2 -->|"inhibits"| ALZHEIMER_S_DISEASE
DNAJB1["DNAJB1"]
DNAJB2 -->|"inhibits"| DNAJB1
DNAJA1["DNAJA1"]
DNAJB2 -->|"inhibits"| DNAJA1
HSP70["HSP70"]
DNAJB2 -->|"inhibits"| HSP70
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
DNAJB2 -->|"inhibits"| PARKINSON_S_DISEASE
DNAJB6["DNAJB6"]
DNAJB6 -->|"inhibits"| DNAJB2
HUNTINGTON["HUNTINGTON"]
HUNTINGTON -->|"inhibits"| DNAJB2
DNAJB1["DNAJB1"]
DNAJB1 -->|"inhibits"| DNAJB2
ALZHEIMER["ALZHEIMER"]
ALZHEIMER -->|"inhibits"| DNAJB2
DNAJA1["DNAJA1"]
DNAJA1 -->|"inhibits"| DNAJB2
HSP70["HSP70"]
HSP70 -->|"inhibits"| DNAJB2
Neuron["Neuron"]
DNAJB2 -->|"expressed in"| Neuron
neurodegeneration["neurodegeneration"]
DNAJB2 -->|"implicated in"| neurodegeneration| Target | Relation | Type | Str |
|---|---|---|---|
| Spinal Muscular Atrophy | inhibits | disease | 0.65 |
| Alzheimer | inhibits | disease | 0.65 |
| Huntington | inhibits | disease | 0.65 |
| Parkinson | inhibits | disease | 0.65 |
| Spinocerebellar Ataxia | inhibits | disease | 0.65 |
| Ataxia | inhibits | disease | 0.65 |
| Neuropathy | inhibits | disease | 0.65 |
| Huntington | stabilizes | disease | 0.65 |
| Neuropathy | stabilizes | disease | 0.65 |
| Parkinson | stabilizes | disease | 0.65 |
| Alzheimer | stabilizes | disease | 0.65 |
| DNAJB1 | inhibits | gene | 0.60 |
| DNAJA1 | inhibits | gene | 0.60 |
| HSP70 | inhibits | gene | 0.60 |
| DNAJB6 | stabilizes | gene | 0.60 |
| protein misfolding | inhibits | process | 0.60 |
| PARKINSON | inhibits | gene | 0.60 |
| Neuron | inhibits | cell_type | 0.60 |
| ALZHEIMER | inhibits | gene | 0.60 |
| HUNTINGTON'S DISEASE | inhibits | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | inhibits | gene | 0.60 |
| HUNTINGTON | inhibits | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| ALZHEIMER'S DISEASE | inhibits | gene | 0.60 |
| PARKINSON'S DISEASE | inhibits | gene | 0.60 |
| PARKINSON | stabilizes | gene | 0.60 |
| Neuron | stabilizes | cell_type | 0.60 |
| Aβ | stabilizes | protein | 0.60 |
| Fus | inhibits | protein | 0.60 |
| Huntington's disease | inhibits | disease | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
| DNAJB6 | inhibits | gene | 0.50 |
| ATAXIN-3 | inhibits | protein | 0.50 |
| Chaperone | inhibits | pathway | 0.50 |
| Proteins | inhibits | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| DNAJB6 | inhibits | gene | 0.60 |
| DNAJB1 | inhibits | gene | 0.60 |
| DNAJA1 | inhibits | gene | 0.60 |
| HSP70 | inhibits | gene | 0.60 |
| DNAJB1 | stabilizes | gene | 0.60 |
| HSP70 | stabilizes | gene | 0.60 |
| DNAJA1 | stabilizes | gene | 0.60 |
| HUNTINGTON | inhibits | gene | 0.60 |
| ALZHEIMER | inhibits | gene | 0.60 |
| ALZHEIMER | stabilizes | gene | 0.60 |
| HUNTINGTON | stabilizes | gene | 0.60 |
| dnaja1 | inhibits | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||