gene

DNAJB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNAJB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

238Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

DNAJB1 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, regulates, activates. Associated with Aging, Als, Ataxia. Connected to 89 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DNAJB1
Protein Type	Chaperone
Target Class	Chaperone
Function	DNAJB1 serves multiple essential cellular functions:
Mechanism of Action	Allosteric modulation of protein-protein interactions with Hsp70
Subcellular Localization	Cytosol: Predominant localization
Druggability	Low (0.35)
Clinical Stage	Phase I
Molecular Weight	38 kDa
Amino Acids	340 aa
Pathways	Chaperone, Complement, Lysosomal Degradation, Oxidative Stress
UniProt ID	M0QXK0
Ensembl ID	ENSG00000132002
GeneCards	DNAJB1
Human Protein Atlas	DNAJB1
Associated Diseases	Als, Alzheimer, Diabetes, Ms, neurodegeneration
Known Drugs/Compounds	115-7c, MAL3-101
Interactions	HSPA1A, HSP90AA1, FKBP5, UBIQUITIN, DNAJA1, HSP70
SciDEX Target	View Target Profile (5 clinical trials)
KG Connections	238 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: DNAJB1 — AlphaFold M0QXK0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DNAJB1["DNAJB1"] -->|"protects against"| mutant_Huntingtin_aggregation["mutant Huntingtin aggregation"]
    DNAJB1["DNAJB1"] -->|"interacts"| mutant_Huntingtin["mutant Huntingtin"]
    DNAJB1["DNAJB1"] -->|"therapeutic target"| Autoimmune["Autoimmune"]
    DNAJB1["DNAJB1"] -->|"regulates"| Multiple_Sclerosis["Multiple Sclerosis"]
    DNAJB1["DNAJB1"] -->|"regulates"| Ms["Ms"]
    DNAJB1["DNAJB1"] -->|"regulates"| Als["Als"]
    h_637a53c9["h-637a53c9"] -->|"therapeutic target"| DNAJB1["DNAJB1"]
    h_637a53c9_1["h-637a53c9"] -->|"targets"| DNAJB1["DNAJB1"]
    STAT3["STAT3"] -->|"activates"| DNAJB1["DNAJB1"]
    HSPA1A["HSPA1A"] -->|"interacts"| DNAJB1["DNAJB1"]
    style DNAJB1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (165)

Target	Relation	Type	Str
Parkinson'S Disease	risk_factor_for	disease	0.85
HSP70	activates	gene	0.75
HSP40	activates	gene	0.75
mutant Huntingtin aggregation	protects_against	process	0.70
mutant Huntingtin	interacts_with	protein	0.70
Spinal Muscular Atrophy	inhibits	disease	0.65
HUNTINGTIN	causes	protein	0.65
Autoimmune	therapeutic_target	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Ms	regulates	disease	0.65
Als	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Huntington	regulates	disease	0.65
Ataxia	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Diabetes	associated_with	disease	0.65
Lymphoma	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Aging	activates	disease	0.65
Huntington	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Parkinson	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65
Aging	biomarker_for	disease	0.65
Ms	causes	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	inhibits	disease	0.65
Huntington	inhibits	disease	0.65
Spinocerebellar Ataxia	inhibits	disease	0.65
Ataxia	inhibits	disease	0.65
Neuropathy	inhibits	disease	0.65
Parkinson	stabilizes	disease	0.65
Huntington	stabilizes	disease	0.65
Neuropathy	stabilizes	disease	0.65
Alzheimer	stabilizes	disease	0.65
ALS	activates	disease	0.65
Aging	contributes_to	disease	0.65
Neurodegeneration	contributes_to	disease	0.65
Huntington	contributes_to	disease	0.65
neurodegeneration	associated_with	disease	0.61
HSPA1A	interacts_with	gene	0.61
HSP90AA1	interacts_with	gene	0.61
FKBP5	interacts_with	gene	0.61
IKBKB	expressed_in	gene	0.60
HSPA1B	expressed_in	gene	0.60

Incoming (73)

Source	Relation	Type	Str
h-637a53c9	targets_gene	hypothesis	0.90
h-637a53c9	targets	hypothesis	0.80
STAT3	activates	protein	0.80
HSPA1A	interacts_with	gene	0.61
HSP90AA1	interacts_with	gene	0.61
FKBP5	interacts_with	gene	0.61
DNAJA2	therapeutic_target	gene	0.60
CD4	regulates	gene	0.60
HSPA1A	regulates	gene	0.60
SCA3	regulates	gene	0.60
HSPA4	regulates	gene	0.60
FOXP1	regulates	gene	0.60
HDAC6	expressed_in	gene	0.60
MAPK8	expressed_in	gene	0.60
TARDBP	expressed_in	gene	0.60
TSC2	biomarker_for	gene	0.60
UBIQUITIN	expressed_in	gene	0.60
BAG3	expressed_in	gene	0.60
UBC	expressed_in	gene	0.60
HSPD1	expressed_in	gene	0.60
DNAJC7	expressed_in	gene	0.60
HSPA6	expressed_in	gene	0.60
JAK2	activates	gene	0.60
HSP70	expressed_in	gene	0.60
HSPA1B	expressed_in	gene	0.60
HSPA1L	expressed_in	gene	0.60
DNAJC10	expressed_in	gene	0.60
HSPH1	expressed_in	gene	0.60
HSP90AB1	expressed_in	gene	0.60
IKBKB	expressed_in	gene	0.60
HSPE1	expressed_in	gene	0.60
HSPA1A	expressed_in	gene	0.60
HSP60	expressed_in	gene	0.60
HSP70	activates	gene	0.60
EGFR	activates	gene	0.60
DNAJB6	inhibits	gene	0.60
DNAJB2	inhibits	gene	0.60
DNAJA1	inhibits	gene	0.60
UBIQUITIN	contributes_to	gene	0.60
STAT3	contributes_to	gene	0.60
DIABETIC RETINOPATHY	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
CANCER	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
NF-ΚB	expressed_in	gene	0.60
NEURODEGENERATION	activates	gene	0.60
HUNTINGTON	activates	gene	0.60
AND	regulates	gene	0.60
PHAGOCYTOSIS	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Can chaperone enhancement approaches overcome tau seed saturation effects in adv

protein folding | 2026-04-06 | 0 hypotheses

APOE4 structural biology and therapeutic targeting strategies

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.595

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DNAJB1

Understanding Entity Pages

Summary

Wiki Pages (21)

DNAJB1 Gene

cbs-psp-daily-action-plan

Oligodendrocyte and Myelin Dysfunction in Corticobasal Syndrome

Proteostasis Network Dysfunction Comparison Across Neurodegenerative Diseases

proteostasis-triad-pulses

Chaperone-Mediated Proteostasis Disease Comparison

Section 102: Proteostasis Network Dysregulation in CBS/PSP

Proteostasis Therapy CBS PSP

Proteostasis Network in Neurodegeneration

DNAJB5 (DnaJ Heat Shock Protein Family Member B5)

Hsp70/Hsp90 Chaperone Pathway in Parkinson's Disease

Section 204: Advanced Proteostasis and Protein Quality Control in CBS/PSP

Proteostasis and ERAD Pathway in Neurodegeneration

Proteostasis Triad Pulses: ISR + Autophagy + Chaperone Induction

dnajc4

DNAJB7

CBS Epigenetic Mechanisms

Section 117: Long-Term Disease Modification Endpoints for CBS/PSP

Molecular Chaperones in Neurodegeneration

HSPB2 Gene (Heat Shock Protein Family B Member 2)

Heat Shock Protein Dysfunction in Progressive Supranuclear Palsy