gene

DNAJB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNAJB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

237Connections

0Hypotheses

5Analyses

50Outgoing

50Incoming

0Experiments

6Debates

Summary

DNAJB1 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, regulates, activates. Associated with Aging, Als, Ataxia. Connected to 89 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DNAJB1
Protein Type	Chaperone
Target Class	Chaperone
Function	DNAJB1 serves multiple essential cellular functions:
Mechanism of Action	Allosteric modulation of protein-protein interactions with Hsp70
Subcellular Localization	Cytosol: Predominant localization
Druggability	Low (0.35)
Clinical Stage	Phase I
Molecular Weight	38 kDa
Amino Acids	340 aa
Pathways	Chaperone, Complement, Lysosomal Degradation, Oxidative Stress
UniProt ID	M0QXK0
Ensembl ID	ENSG00000132002
GeneCards	DNAJB1
Human Protein Atlas	DNAJB1
Associated Diseases	Als, Alzheimer, Diabetes, Ms, neurodegeneration
Known Drugs/Compounds	115-7c, MAL3-101
Interactions	Alpha-Synuclein, ALPHA-SYNUCLEIN, ALZHEIMER, ALZHEIMER'S DISEASE, APOE4, ASTROCYTE
SciDEX Target	View Target Profile (5 clinical trials)
KG Connections	237 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: DNAJB1 — AlphaFold M0QXK0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DNAJB1["DNAJB1"] -->|"protects against"| mutant_Huntingtin_aggregation["mutant Huntingtin aggregation"]
    DNAJB1["DNAJB1"] -->|"interacts"| mutant_Huntingtin["mutant Huntingtin"]
    DNAJB1["DNAJB1"] -->|"therapeutic target"| Autoimmune["Autoimmune"]
    DNAJB1["DNAJB1"] -->|"regulates"| Multiple_Sclerosis["Multiple Sclerosis"]
    DNAJB1["DNAJB1"] -->|"regulates"| Ms["Ms"]
    DNAJB1["DNAJB1"] -->|"regulates"| Als["Als"]
    h_637a53c9["h-637a53c9"] -->|"therapeutic target"| DNAJB1["DNAJB1"]
    h_637a53c9_1["h-637a53c9"] -->|"targets"| DNAJB1["DNAJB1"]
    STAT3["STAT3"] -->|"activates"| DNAJB1["DNAJB1"]
    HSPA1A["HSPA1A"] -->|"interacts"| DNAJB1["DNAJB1"]
    style DNAJB1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (167)

Target	Relation	Type	Str
tau misfolding propagation	prevents	mechanism	0.90
Hsp70	enhances	protein	0.90
Parkinson'S Disease	risk_factor_for	disease	0.85
HSP70	activates	gene	0.75
HSP40	activates	gene	0.75
APOE4 folding	regulates	process	0.70
protein_folding	regulates	process	0.70
mutant Huntingtin aggregation	protects_against	process	0.70
incoming tau seeds	regulates	mechanism	0.70
mutant Huntingtin	interacts_with	protein	0.70
alpha-synuclein oligomerization	inhibits	mechanism	0.70
Neuroinflammation	regulates	disease	0.65
ALS	activates	disease	0.65
Huntington	contributes_to	disease	0.65
Neuropathy	stabilizes	disease	0.65
Inflammation	regulates	disease	0.65
Neuropathy	inhibits	disease	0.65
Alzheimer	stabilizes	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65
Ms	causes	disease	0.65
Autoimmune	therapeutic_target	disease	0.65
Ataxia	inhibits	disease	0.65
Parkinson	stabilizes	disease	0.65
Huntington	stabilizes	disease	0.65
Huntington	regulates	disease	0.65
Aging	biomarker_for	disease	0.65
Aging	contributes_to	disease	0.65
Neurodegeneration	contributes_to	disease	0.65
Neurodegeneration	activates	disease	0.65
Tumor	expressed_in	disease	0.65
Als	activates	disease	0.65
Lymphoma	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Spinal Muscular Atrophy	inhibits	disease	0.65
Aging	activates	disease	0.65
Huntington	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Ataxia	regulates	disease	0.65
HUNTINGTIN	causes	protein	0.65
Parkinson	inhibits	disease	0.65
Neurodegeneration	regulates	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Diabetes	associated_with	disease	0.65
Cancer	expressed_in	disease	0.65
Spinocerebellar Ataxia	inhibits	disease	0.65
Huntington	inhibits	disease	0.65

Incoming (70)

Source	Relation	Type	Str
h-637a53c9	targets	hypothesis	0.90
STAT3	activates	protein	0.80
HSPA1A	interacts_with	gene	0.61
HSP90AA1	interacts_with	gene	0.61
FKBP5	interacts_with	gene	0.61
AND	regulates	gene	0.60
AGING	biomarker_for	gene	0.60
HUNTINGTON	inhibits	gene	0.60
DNAJA2	therapeutic_target	gene	0.60
CD4	regulates	gene	0.60
HSPA1A	regulates	gene	0.60
SCA3	regulates	gene	0.60
HSPA4	regulates	gene	0.60
FOXP1	regulates	gene	0.60
HDAC6	expressed_in	gene	0.60
MAPK8	expressed_in	gene	0.60
TARDBP	expressed_in	gene	0.60
TSC2	biomarker_for	gene	0.60
UBIQUITIN	expressed_in	gene	0.60
JAK2	activates	gene	0.60
DNAJB6	inhibits	gene	0.60
DNAJA1	inhibits	gene	0.60
UBIQUITIN	contributes_to	gene	0.60
STAT3	contributes_to	gene	0.60
CANCER	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
NF-ΚB	expressed_in	gene	0.60
NEURODEGENERATION	activates	gene	0.60
HUNTINGTON	activates	gene	0.60
PHAGOCYTOSIS	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
PARKINSON	inhibits	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
UBC	expressed_in	gene	0.60
HSPD1	expressed_in	gene	0.60
DNAJC7	expressed_in	gene	0.60
HSPA6	expressed_in	gene	0.60
HSP70	expressed_in	gene	0.60
HSPA1B	expressed_in	gene	0.60
HSPA1L	expressed_in	gene	0.60
DNAJC10	expressed_in	gene	0.60
HSPH1	expressed_in	gene	0.60
HSP90AB1	expressed_in	gene	0.60
IKBKB	expressed_in	gene	0.60
HSPE1	expressed_in	gene	0.60
HSPA1A	expressed_in	gene	0.60
HSP60	expressed_in	gene	0.60
HSP70	activates	gene	0.60
BAG3	expressed_in	gene	0.60
EGFR	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (5)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (6)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning DNAJB1 in their description or question text

No additional research found

DNAJB1

Understanding Entity Pages

Summary

Wiki Pages (3)

DNAJB1 Gene

DNAJB12 — DnaJ Heat Shock Protein Family (Hsp40) Member B12

DNAJB1 Protein

Pathway Diagram

Outgoing (167)

Incoming (70)

Targeting Hypotheses (0)

Mentioning Analyses (5)

Does DNAJB6 directly inhibit cross-seeding between tau, α-synuclein, and TDP-43

Can chaperone enhancement approaches overcome tau seed saturation effects in adv

Tau propagation mechanisms and therapeutic interception points

APOE4 structural biology and therapeutic targeting strategies

APOE4 structural biology and therapeutic targeting strategies

Experiments (0)

Related Papers (0)

Debates (6)

While DNAJB1 enhancement showed promise, the debate raised concerns about whethe

The debate revealed that DNAJB6 evidence is limited to polyglutamine aggregation

Investigate prion-like spreading of tau pathology through connected brain region

APOE4 differs from APOE3 by C112R causing domain interaction that alters lipid b

Tau propagation mechanisms and therapeutic interception points

What are the mechanisms underlying apoe4 structural biology and therapeutic targ

Related Research