gene

DVL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DVL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

23Connections

0Hypotheses

0Analyses

17Outgoing

6Incoming

0Experiments

0Debates

Summary

DVL1 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, interacts with, implicated in. Associated with Als, Cancer, Ms. Connected to 17 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DVL1
Function	Wnt signal transduction: Central mediator of canonical and non-canonical Wnt signaling
Subcellular Localization	** \| Cytoplasm, Cell membrane, Synapses \|
Molecular Weight	70 kDa
Amino Acids	80 aa
Pathways	Wnt signaling, Wnt pathway, Wnt, MAPK
GeneCards	DVL1
Human Protein Atlas	DVL1
Size	670 amino acids (canonical isoform)
Molecular weight	~70-80 kDa
Isoforms	Multiple isoforms due to alternative splicing
Associated Diseases	neurodegeneration
Interactions	AND, LEF1, LRP6, LRRK2, PARKINSON, PARKINSON'S DISEASE
KG Connections	23 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DVL1["<b>DVL1</b>"]
    Cancer{"Cancer"}
    DVL1 -->|"expressed in"| Cancer
    Ms{"Ms"}
    DVL1 -->|"expressed in"| Ms
    Parkinson{"Parkinson"}
    DVL1 -->|"interacts with"| Parkinson
    Als{"Als"}
    DVL1 -->|"interacts with"| Als
    DVL1 -->|"interacts with"| Ms
    MYC["MYC"]
    DVL1 -->|"expressed in"| MYC
    Wnt(["Wnt"])
    DVL1 -->|"expressed in"| Wnt
    LEF1["LEF1"]
    DVL1 -->|"expressed in"| LEF1
    LRP6["LRP6"]
    DVL1 -->|"interacts with"| LRP6
    LRRK2["LRRK2"]
    DVL1 -->|"interacts with"| LRRK2
    DVL1 -->|"interacts with"| Wnt
    neurodegeneration["neurodegeneration"]
    DVL1 -->|"implicated in"| neurodegeneration
    RB1["RB1"]
    RB1 -->|"expressed in"| DVL1
    LEF1 -->|"expressed in"| DVL1
    MYC -->|"expressed in"| DVL1
    CANCER["CANCER"]
    CANCER -->|"expressed in"| DVL1
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"interacts with"| DVL1
    style DVL1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (17)

Target	Relation	Type	Str
Ms	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Parkinson	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Wnt	interacts_with	pathway	0.60
LRP6	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
Wnt	expressed_in	pathway	0.60
AND	interacts_with	gene	0.60
WNT	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
MYC	expressed_in	gene	0.60
Wnt signaling	participates_in	pathway	0.60
LEF1	expressed_in	gene	0.60
LEF1	interacts_with	gene	0.60
LEF1	co_expressed_with	gene	0.60

Incoming (6)

Source	Relation	Type	Str
RB1	expressed_in	gene	0.60
LEF1	expressed_in	gene	0.60
MYC	expressed_in	gene	0.60
LRRK2	interacts_with	gene	0.60
CANCER	expressed_in	gene	0.60
PARKINSON'S DISEASE	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity