LRP6

Understanding Entity Pages

This page aggregates everything SciDEX knows about LRP6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

LRP6 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with ALS, Als, Alzheimer. Connected to 70 entities in the SciDEX knowledge graph.

View on Wiki →

graph TD
    LRP6["<b>LRP6</b>"]
    cardiac_hypertrophy{"cardiac hypertrophy"}
    LRP6 -->|"protects against"| cardiac_hypertrophy
    HSP90_["HSP90alpha"]
    LRP6 -->|"interacts with"| HSP90_
    CTSD["CTSD"]
    LRP6 -->|"interacts with"| CTSD
    LRP6 -->|"activates"| CTSD
    Atherosclerosis{"Atherosclerosis"}
    LRP6 -->|"regulates"| Atherosclerosis
    Cardiovascular{"Cardiovascular"}
    LRP6 -->|"regulates"| Cardiovascular
    Als{"Als"}
    LRP6 -->|"regulates"| Als
    Fibrosis{"Fibrosis"}
    LRP6 -->|"activates"| Fibrosis
    LRP6 -->|"activates"| Als
    Cardiac{"Cardiac"}
    LRP6 -->|"inhibits"| Cardiac
    Heart_Failure{"Heart Failure"}
    LRP6 -->|"activates"| Heart_Failure
    Ms{"Ms"}
    LRP6 -->|"activates"| Ms
    LRP5["LRP5"]
    LRP5 -->|"associated with"| LRP6
    CTSD -->|"inhibits"| LRP6
    LDLR["LDLR"]
    LDLR -->|"associated with"| LRP6
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"interacts with"| LRP6
    DVL1["DVL1"]
    DVL1 -->|"interacts with"| LRP6
    AKT1["AKT1"]
    AKT1 -->|"activates"| LRP6
    CANCER["CANCER"]
    CANCER -->|"activates"| LRP6
    RBPJ["RBPJ"]
    RBPJ -->|"regulates"| LRP6
    APOE["APOE"]
    APOE -->|"contributes to"| LRP6
    LDLR -->|"contributes to"| LRP6
    style LRP6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0