protein

ERN1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ERN1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

ERN1 (Endoplasmic Reticulum to Nucleus signaling 1), also known as IRE1 (Inositol-Requiring Enzyme 1), is a critical transmembrane protein that functions as a primary sensor of endoplasmic reticulum (ER) stress.

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🔬 Protein Info

Gene Symbol	ERN1PROTEIN
Chromosome	6p21.1.
Function	is a critical transmembrane protein that functions as a primary sensor of endoplasmic reticulum (ER) stress.
GeneCards	ERN1PROTEIN
Human Protein Atlas	ERN1PROTEIN
Kinase Domain	Catalyzes autophosphorylation upon activation
RNase Domain	Cleaves XBP1 mRNA to produce the spliced form (XBP1s)
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	rapamycin
Interactions	ABCD3, ACETYL-COA, Actin, AKT, AKT1, AKT1S1
KG Connections	980 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ERN1/IRE1 Protein — ER Stress Sensor

protein · 1169 words

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Pathway Diagram

graph TD
    ERN1PROTEIN["ERN1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    ERN1PROTEIN -->|"implicated_in"| neurodegeneration
    style ERN1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning ERN1PROTEIN in their description or question text

No additional research found