Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FMRP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | FMRP |
| Function | Fmrp Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. |
| Pathways | Chromatin Dynamics, RNA Binding, mRNA Translation, mRNA Transport |
| GeneCards | FMRP |
| Human Protein Atlas | FMRP |
| Associated Diseases | ALS |
| Interactions | HNRNPA2B1, RNA, SYNCRIP, TAR, TDP-43, DNA |
| KG Connections | 45 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
FMRP["<b>FMRP</b>"]
Chromatin_Dynamics["Chromatin Dynamics"]
FMRP -->|"participates_in"| Chromatin_Dynamics
RNA_Binding["RNA Binding"]
FMRP -->|"participates_in"| RNA_Binding
mRNA_Transport["mRNA Transport"]
FMRP -->|"participates_in"| mRNA_Transport
mRNA_Translation["mRNA Translation"]
FMRP -->|"participates_in"| mRNA_Translation
SLC1A2(["SLC1A2"])
FMRP -->|"regulates"| SLC1A2
Tdp_43["Tdp-43"]
FMRP -->|"associated_with"| Tdp_43
AUTISM{"AUTISM"}
AUTISM -->|"activates"| FMRP
FMR1(["FMR1"])
FMR1 -->|"activates"| FMRP
style FMRP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7| Target | Relation | Type | Str |
|---|---|---|---|
| RNA Metabolism | regulates | process | 0.90 |
| Chromatin Dynamics | participates_in | biological_process | 0.80 |
| RNA Binding | participates_in | biological_process | 0.80 |
| mRNA Transport | participates_in | biological_process | 0.80 |
| mRNA Translation | participates_in | biological_process | 0.80 |
| TDP-43 | mitigates_toxicity | protein | 0.80 |
| neurons | expressed_in | cell_type | 0.80 |
| RNA | interacts_with | gene | 0.65 |
| SLC1A2 | regulates | gene | 0.60 |
| ALS | associated_with | disease | 0.60 |
| autism spectrum disorder | activates | disease | 0.60 |
| astrocytes | expressed_in | cell_type | 0.60 |
| RNA | regulates | gene | 0.60 |
| autism spectrum disorder | regulates | disease | 0.60 |
| RNA | activates | gene | 0.60 |
| G3BP1 | associated_with | gene | 0.60 |
| G3BP2 | associated_with | gene | 0.60 |
| HNRNPA2B1 | interacts_with | gene | 0.55 |
| SYNCRIP | interacts_with | gene | 0.55 |
| TAR | interacts_with | gene | 0.55 |
| TDP-43 | interacts_with | gene | 0.55 |
| Tdp-43 | associated_with | pathway | 0.50 |
| Tdp-43 | inhibits | pathway | 0.50 |
| Tdp-43 | interacts_with | pathway | 0.50 |
| Tdp-43 | activates | pathway | 0.50 |
| MOTOR NEURONS | activates | concept | 0.50 |
| NEURONS | activates | concept | 0.50 |
| STRESS GRANULES | activates | concept | 0.50 |
| SYNAPSE | inhibits | concept | 0.50 |
| MOTOR NEURONS | inhibits | concept | 0.50 |
| NEURONS | inhibits | concept | 0.50 |
| GLUTAMATE | regulates | concept | 0.50 |
| Neuron | activates | cell_type | 0.50 |
| Astrocyte | activates | cell_type | 0.50 |
| Astrocytes | inhibits | cell_type | 0.50 |
| Astrocyte | inhibits | cell_type | 0.50 |
| GLUTAMATE | inhibits | concept | 0.50 |
| Astrocytes | activates | cell_type | 0.50 |
| G3BP1 | co_expressed_with | gene | 0.50 |
| G3BP2 | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||