FOXO3A

Understanding Entity Pages

This page aggregates everything SciDEX knows about FOXO3A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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graph TD
    FOXO3A["FOXO3A"]
    FOXO3A -->|"interacts"| SIRT3["SIRT3"]
    FOXO3A -->|"interacts"| POLRMT["POLRMT"]
    FOXO3A -->|"regulates"| autophagy["autophagy"]
    FOXO3A -->|"inhibits"| inflammation["inflammation"]
    FOXO3A -->|"inhibits"| ferroptosis["ferroptosis"]
    FOXO3A -->|"regulates"| mitochondria["mitochondria"]
    FOXO3A -->|"regulates"| HIF1A["HIF1A"]
    calycosin["calycosin"] -->|"regulates"| FOXO3A
    STAT3["STAT3"] -->|"regulates"| FOXO3A
    AKT["AKT"] -->|"phosphorylates"| FOXO3A
    AMPK["AMPK"] -->|"activates"| FOXO3A
    PI3K_AKT_pathway["PI3K/AKT pathway"] -->|"activates"| FOXO3A
    PI3K["PI3K"] -->|"activates"| FOXO3A
    trifluoperazine["trifluoperazine"] -->|"activates"| FOXO3A