gene

GS3KB

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about GS3KB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

GSK3B — Glycogen Synthase Kinase 3 Beta

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🧬 Gene Info

Gene Symbol	GSK3B
Full Name	Glycogen Synthase Kinase 3 Beta
Aliases	GSK-3β, TPKII, Tau tubulin kinase (TTBK)
Chromosome	3q13.33
Protein Type	Serine/Threonine Kinase
Function	is a constitutively active serine/threonine kinase encoded by the GSK3B gene that plays central and multifaceted roles in cellular physiology[@woodgett1990].
Molecular Weight	47 kDa (420 amino acids)
Amino Acids	420 aa
Exons	12
Pathways	Akt, Cholesterol, Mapk, Microrna, Nf-Kb
GeneCards	GSK3B
Human Protein Atlas	GSK3B
Wnt signaling	GSK3B is a key component of the Wnt/β-catenin pathway, where it phosphorylates β-catenin targeting it for degradation<sup>[2]</sup>
Glycogen metabolism	Originally identified as a regulator of glycogen synthase, hence its name
Synaptic plasticity	GSK3B regulates NMDA receptor trafficking, AMPA receptor internalization, and long-term potentiation (LTP)<sup>[3]</sup>
Associated Diseases	Aging, ALS, Alzheimer, Alzheimer disease, Alzheimer's disease
Known Drugs/Compounds	ANTHOCYANINS, Ficus deltoidea, LITHIUM, rapamycin, RAPAMYCIN, SB216763
Interactions	ABCA1, ACETYL-COA, ACHE, Actin, AD, ADAM17
SciDEX Hypotheses	GSK3β-Dependent Tau Phosphorylation Cycling Modula
KG Connections	1193 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GSK3B — Glycogen Synthase Kinase 3 Beta

gene · 891 words

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Pathway Diagram

graph TD
    GS3KB["GS3KB"]
    neurodegeneration["neurodegeneration"]
    GS3KB -->|"implicated_in"| neurodegeneration
    style GS3KB fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning GS3KB in their description or question text

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