gene

HDAC10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HDAC10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

12Outgoing

3Incoming

0Experiments

Summary

Histone Deacetylase 10 - role in autophagy regulation, neuroinflammation, and neurodegenerative disease

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🧬 Gene Info

Gene Symbol	HDAC10
Full Name	HDAC10
Aliases	Histone Deacetylase 10
Chromosome	22q13.33.
Protein Type	Gene
Function	is a class IIb histone deacetylase encoded by the HDAC10 gene located on chromosome 22q13.
Primary Expression	both neurons and glia, with astrocytic and microglial expression particularly relevant to understanding its role in neuroinflammation
Subcellular Localization	and function
Molecular Weight	78 kDa
Amino Acids	669 aa
Exons	16
Pathways	Epigenetic
NCBI Gene ID	Search NCBI
GeneCards	HDAC10
Human Protein Atlas	HDAC10
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	HDAC1, DNMT3A, AND
KG Connections	15 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HDAC10["<b>HDAC10</b>"]
    Als{"Als"}
    HDAC10 -->|"therapeutic_target"| Als
    Carcinoma{"Carcinoma"}
    HDAC10 -->|"therapeutic_target"| Carcinoma
    Cancer{"Cancer"}
    HDAC10 -->|"therapeutic_target"| Cancer
    Tumor{"Tumor"}
    HDAC10 -->|"activates"| Tumor
    HDAC1(["HDAC1"])
    HDAC10 -->|"activates"| HDAC1
    DNMT3A(["DNMT3A"])
    HDAC10 -->|"activates"| DNMT3A
    AND(["AND"])
    AND -->|"activates"| HDAC10
    style HDAC10 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (12)

Target	Relation	Type	Str
Als	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
HDAC1	activates	gene	0.60
DNMT3A	activates	gene	0.60
VEGF	therapeutic_target	gene	0.60
EGF	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
Epigenetic	activates	pathway	0.60
epigenetic regulation	participates_in	pathway	0.60

Incoming (3)

Source	Relation	Type	Str
DNMT3A	activates	gene	0.60
HDAC1	activates	gene	0.60
AND	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HDAC10

Understanding Entity Pages

Summary

Wiki Pages (9)

HDAC10 Gene

Epigenetic Dysregulation in Neurodegeneration

HDAC7 Protein

Histone Deacetylase (HDAC) Enzymes

HDAC Inhibitors for Neurodegeneration — Investment Landscape

Histone Deacetylases (HDACs)

HDAC10 Protein

Proteins