concept

CIRCADIAN RHYTHM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CIRCADIAN RHYTHM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1265Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

CIRCADIAN RHYTHM is a concept in neurodegeneration research. Key relationships include: regulates, associated with, activates. Associated with ALS, Aging, Als. Connected to 376 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	CIRCADIAN RHYTHM
Related Pathways	Circadian Rhythm
Linked Hypotheses	4 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CIRCADIAN_RHYTHM["CIRCADIAN RHYTHM"]
    CIRCADIAN_RHYTHM -->|"regulates"| lipid_metabolism["lipid metabolism"]
    CIRCADIAN_RHYTHM -->|"inhibits"| Ischemia["Ischemia"]
    CIRCADIAN_RHYTHM -->|"inhibits"| Aging["Aging"]
    CIRCADIAN_RHYTHM -->|"regulates"| Ms["Ms"]
    CIRCADIAN_RHYTHM -->|"regulates"| Depression["Depression"]
    CIRCADIAN_RHYTHM -->|"regulates"| Cancer["Cancer"]
    CIRCADIAN_RHYTHM -->|"regulates"| Tumor["Tumor"]
    BMAL1["BMAL1"] -->|"regulates"| CIRCADIAN_RHYTHM
    BANG["BANG"] -->|"regulates"| CIRCADIAN_RHYTHM
    CLOCK["CLOCK"] -->|"regulates"| CIRCADIAN_RHYTHM
    CRY["CRY"] -->|"regulates"| CIRCADIAN_RHYTHM

Outgoing (457)

Target	Relation	Type	Str
Circadian Rhythm	regulates	pathway	1.00
IMMUNE CELLS	regulates	entity	0.92
DIGESTION	regulates	entity	0.90
ABSORPTION	regulates	entity	0.90
INTESTINAL BARRIER FUNCTION	regulates	entity	0.90
IMMUNE FUNCTION	regulates	entity	0.90
Circadian Rhythm	associated_with	pathway	0.80
Inflammation	activates	disease	0.75
Aging	regulates	disease	0.75
Als	therapeutic_target	disease	0.75
Cancer	associated_with	disease	0.75
Autophagy	regulates	pathway	0.70
INSULIN RESISTANCE	activates	gene	0.70
Oxidative Stress	regulates	pathway	0.70
Circadian Rhythm	interacts_with	pathway	0.70
Nf-Κb	regulates	pathway	0.70
Epigenetic	regulates	pathway	0.70
Ischemia	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Ms	regulates	disease	0.65
Depression	regulates	disease	0.65
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
Ms	activates	disease	0.65
Migraine	activates	disease	0.65
Diabetes	activates	disease	0.65
Obesity	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Als	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Carcinoma	activates	disease	0.65
Fibrosis	activates	disease	0.65
Tumor	associated_with	disease	0.65
Als	interacts_with	disease	0.65
Senescence	regulates	disease	0.65
Ms	interacts_with	disease	0.65
Fibrosis	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Cancer	activates	disease	0.65
Cardiovascular	regulates	disease	0.65
Atherosclerosis	therapeutic_target	disease	0.65
Ms	contributes_to	disease	0.65
Cardiac	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
ALS	degrades	disease	0.65
Cancer	degrades	disease	0.65
ALS	regulates	disease	0.65

Incoming (808)

Source	Relation	Type	Str
OBSTRUCTIVE SLEEP APNEA SYNDROME	associated_with	entity	0.95
HYPOTHALAMUS	regulates	entity	0.95
MELATONIN	biomarker_for	entity	0.90
INTERMITTENT HYPOXIA	associated_with	entity	0.90
SLEEP FRAGMENTATION	associated_with	entity	0.90
LIGHT	modulates	entity	0.90
SLEEP	modulates	entity	0.90
EATING TIMES	modulates	entity	0.90
BMAL1	associated_with	gene	0.90
CLOCK	regulates	gene	0.80
GENES	regulates	gene	0.80
AUTOPHAGY	regulates	gene	0.70
INFLAMMATION	activates	gene	0.70
OXIDATIVE STRESS	regulates	gene	0.70
AGING	regulates	gene	0.70
NF-ΚB	regulates	gene	0.70
PI3K	associated_with	gene	0.70
AKT	associated_with	gene	0.70
BMAL1	expressed_in	gene	0.70
GENES	expressed_in	gene	0.70
CRY1	expressed_in	gene	0.70
AGING	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
ERK	inhibits	gene	0.60
PI3K	inhibits	gene	0.60
AKT	inhibits	gene	0.60
PTEN	inhibits	gene	0.60
PDK1	inhibits	gene	0.60
BMAL1	inhibits	gene	0.60
PAK1	regulates	gene	0.60
P62	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
BMAL1	regulates	gene	0.60
SOX2	regulates	gene	0.60
NESTIN	regulates	gene	0.60
CANCER	regulates	gene	0.60
MET	regulates	gene	0.60
FOS	activates	gene	0.60
C-FOS	activates	gene	0.60
SIRT1	activates	gene	0.60
BMAL1	activates	gene	0.60
CLOCK	associated_with	gene	0.60
CANCER	therapeutic_target	gene	0.60
CLOCK	interacts_with	gene	0.60
UBIQUITIN	regulates	gene	0.60
UBR5	regulates	gene	0.60
PER2	regulates	gene	0.60
MTOR	regulates	gene	0.60
MYC	regulates	gene	0.60
XPA	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Circadian Rhythm Entrainment of Reactive Astrocytes	0.481	neurodegeneration	Astrocyte reactivity subtypes in neurode

Mentioning Analyses (2)

Scientific analyses that reference this entity

Is disrupted sleep a cause or consequence of neurodegeneration? Analyze the bidi

neurodegeneration | 2026-04-02 | 0 hypotheses

Is disrupted sleep a cause or consequence of neurodegeneration? Analyze the bidi

neurodegeneration | 2026-04-02 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
BMAL1-HIF2A heterodimer modulates circadian variations of myocardial injury. [PMID:40269168]	Ruan W, Li T, Bang IH, Lee J, Deng W, Ma	Nature	2025	1
Obstructive sleep apnea syndrome, orexin, and sleep-wake cycle: The link with th [PMID:39864923]	Fernandes M, Liguori C	Handb Clin Neurol	2025	1
Circadian Influences on Brain Lipid Metabolism and Neurodegenerative Diseases. [PMID:39728504]	Hussain Y, Dar MI, Pan X	Metabolites	2024	1
Circadian rhythm regulates the function of immune cells and participates in the [PMID:38678017]	Zeng Y, Guo Z, Wu M, Chen F, Chen L	Cell Death Discov	2024	1
Circadian Clock Regulation on Lipid Metabolism and Metabolic Diseases. [PMID:32705594]	Pan X, Mota S, Zhang B	Adv Exp Med Biol	2020	1
BMAL1 attenuates myocardial infarction-induced fibrosis via suppressing p-SMAD3/ [PMID:41909150]	Zhang D, Wang H, Gu Z, Zhang L, Hu Z, Wa	Biochemistry and biophysics re	2026	0
Multifunctional hydrogel delivery of mesenchymal stem cell secretome suppresses [PMID:41092646]	Lin L, Liang X, Xu Z, Li Y, Guo Z et al.	Biomaterials	2026	0
The Liver Clock Tunes Transcriptional Rhythms in Skeletal Muscle to Regulate Mit [PMID:41486525]	Sica V, Sato T, Tsialtas I, Hernandez S,	J Biol Rhythms	2026	0
Glycaemic, appetite and circadian benefits of a dairy-enriched diet with high-pr [PMID:41578008]	Tsameret S, Froy O, Matz Y, Landau Z, Tw	Diabetologia	2026	0
Bmal1 Regulates Vascular Calcification via Noncanonical Circadian Pathway-Brief [PMID:41608773]	He M, Sun Y, Tang C, Huang F, Zhu Z et a	Arterioscler Thromb Vasc Biol	2026	0
Liver-specific knockout of CD73 exacerbated alcohol-associated steatohepatitis b [PMID:41833677]	Wu X, Zhang Q, Wang QQ, Liu ZN, Ni YY et	Int J Biol Macromol	2026	0
Adrenaline restores Bmal1 transcriptional rhythms dampened by SARS-CoV-2 infecti [PMID:41927871]	Suga K, Koizumi H, Asano Y, Hamasaki S,	Scientific reports	2026	0
Impact of acute blue light irradiation on the molecular clock and markers associ [PMID:41944887]	Vibriani A, Chen X, Kajiwara S, Orihara	J Mol Med (Berl)	2026	0
The clock out of sync: Insights into circadian disruption in wake-up vs non-wake [PMID:41945262]	Zhang X, Chen Z, Gu S, Zhu YL, Yu L et a	Adv Clin Exp Med	2026	0
Circadian disruption and its clinical implications in Parkinson's disease: A Nar [PMID:41905255]	Kataoka H, Saeki K, Sugie K, Obayashi K	Sleep medicine	2026	0
The neuroprotective role of eugenol against glyphosate-induced toxicity in rats: [PMID:41922126]	Bolat İ, Alat Ö, Orhan B, Dereli E, Teki	Tissue & cell	2026	0
Circadian abnormalities, molecular clock gene and chronobiological treatment for [PMID:41913359]	Chakraborty S, Srivastava V	Chronobiology international	2026	0
The rhythm of decline: Circadian disruption in neurodegeneration. [PMID:41066745]	Singh J, Kumar D, Kaur J, Singh A	Journal of food and drug analy	2025	0
Core Circadian Protein BMAL1: Implication for Nervous System Functioning and Its [PMID:41440117]	Smirnova KV, Smirnova LP, Amstislavskaya	Brain sciences	2025	0
Pharmacological targeting of BMAL1 modulates circadian and immune pathways. [PMID:40133642]	Pu H, Bailey LC, Bauer LG, Voronkov M, B	Nature chemical biology	2025	0

CIRCADIAN RHYTHM

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Sleep and Circadian Dysfunction in Alzheimer's Disease

CBS/PSP Supplements Guide

CBS/PSP Rehabilitation Master Guide

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Alzheimer's Disease Mechanism Index

Therapeutics

Alzheimer's Disease

Microglial Cells — Cell Type Hierarchy

GSK-3β in Neurodegeneration