concept

CIRCADIAN RHYTHM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CIRCADIAN RHYTHM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1265Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

4Experiments

Summary

CIRCADIAN RHYTHM is a concept in neurodegeneration research. Key relationships include: regulates, associated with, activates. Associated with ALS, Aging, Als. Connected to 376 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	CIRCADIAN RHYTHM
Related Pathways	Circadian Rhythm
Linked Hypotheses	4 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CIRCADIAN_RHYTHM["CIRCADIAN RHYTHM"]
    CIRCADIAN_RHYTHM -->|"regulates"| lipid_metabolism["lipid metabolism"]
    CIRCADIAN_RHYTHM -->|"inhibits"| Ischemia["Ischemia"]
    CIRCADIAN_RHYTHM -->|"inhibits"| Aging["Aging"]
    CIRCADIAN_RHYTHM -->|"regulates"| Ms["Ms"]
    CIRCADIAN_RHYTHM -->|"regulates"| Depression["Depression"]
    CIRCADIAN_RHYTHM -->|"regulates"| Cancer["Cancer"]
    CIRCADIAN_RHYTHM -->|"regulates"| Tumor["Tumor"]
    BMAL1["BMAL1"] -->|"regulates"| CIRCADIAN_RHYTHM
    BANG["BANG"] -->|"regulates"| CIRCADIAN_RHYTHM
    CLOCK["CLOCK"] -->|"regulates"| CIRCADIAN_RHYTHM
    CRY["CRY"] -->|"regulates"| CIRCADIAN_RHYTHM

Outgoing (457)

Target	Relation	Type	Str
Circadian Rhythm	regulates	pathway	1.00
Gastrointestinal Function	regulates	process	0.95
Immune Cell Function	regulates	process	0.95
Gastrointestinal Disease	regulates	disease	0.95
IMMUNE CELLS	regulates	entity	0.92
Gut Health	modulates	phenotype	0.90
Tumor Development	involved_in	disease	0.90
Immune Response	regulates	process	0.90
DIGESTION	regulates	entity	0.90
ABSORPTION	regulates	entity	0.90
INTESTINAL BARRIER FUNCTION	regulates	entity	0.90
IMMUNE FUNCTION	regulates	entity	0.90
Gut Health	regulates	phenotype	0.90
Myocardial Injury	modulates	phenotype	0.90
Digestion	regulates	process	0.90
Absorption	regulates	process	0.90
Intestinal Motility	regulates	process	0.90
Intestinal Barrier Function	regulates	process	0.90
Immune Function	regulates	process	0.90
Gut Microbiome	regulates	process	0.90
Cancer	involved_in	disease	0.90
Brain Lipid Metabolism	regulates	process	0.90
Gastrointestinal Immune Function	regulates	process	0.90
Microbiome Composition	modulates	process	0.90
Nutrient Absorption	regulates	process	0.90
Gastrointestinal Motility	modulates	process	0.90
Intestinal Microbiota	modulates	pathway	0.90
Digestion	associated_with	process	0.90
Mood Disorders	regulates	disease	0.90
Microglial Activation	regulates	mechanism	0.90
Myocardial Injury	associated_with	disease	0.85
Gut Health	contributes_to	phenotype	0.85
Intestinal Homeostasis	regulates	process	0.85
myocardial infarction	associated_with	disease	0.80
daytime napping	regulates	phenotype	0.80
Chronic Gastrointestinal Disease	associated_with	disease	0.80
Tumor Microenvironment	regulates	process	0.80
Microglia	regulates	cell	0.80
Microglia Metabolism	regulates	process	0.80
Circadian Rhythm	associated_with	pathway	0.80
Inflammatory Gastrointestinal Conditions	associated_with	disease	0.78
chemotherapy efficacy	modulates	phenotype	0.75
Inflammation	activates	disease	0.75
Aging	regulates	disease	0.75
Als	therapeutic_target	disease	0.75
Cancer	associated_with	disease	0.75
Metabolic Pathways	regulates	pathway	0.75
brain lipid metabolism	regulates	biological_process	0.70
Alzheimer's disease	associated_with	disease	0.70
Parkinson's disease	associated_with	disease	0.70

Incoming (808)

Source	Relation	Type	Str
CIRCADIAN RHYTHM	regulates	gene	1.00
CLOCK	drives	gene	0.95
BMAL1	drives	gene	0.95
Alzheimer's Disease	associated_with	disease	0.95
Parkinson's Disease	associated_with	disease	0.95
Huntington's Disease	associated_with	disease	0.95
OBSTRUCTIVE SLEEP APNEA SYNDROME	associated_with	entity	0.95
HYPOTHALAMUS	regulates	entity	0.95
Suprachiasmatic Nucleus	regulates	cell_type	0.95
PER	drives	gene	0.95
CRY	drives	gene	0.95
ASTROCYTES	regulates	cell_type	0.95
suprachiasmatic nucleus	associated_with	brain_region	0.93
BMAL1	associated_with	gene	0.90
HIF2A	regulates	protein	0.90
Intermittent Hypoxia	associated_with	mechanism	0.90
Hypothalamus	regulates	cell_type	0.90
MELATONIN	biomarker_for	entity	0.90
INTERMITTENT HYPOXIA	associated_with	entity	0.90
SLEEP FRAGMENTATION	associated_with	entity	0.90
LIGHT	modulates	entity	0.90
SLEEP	modulates	entity	0.90
EATING TIMES	modulates	entity	0.90
BMAL1	involved_in	protein	0.90
Hypothalamus	mediates	cell_type	0.90
SIRT1	regulates	protein	0.85
Environmental Cycles	modulates	phenotype	0.85
Light Exposure	modulates	phenotype	0.85
Sleep	modulates	phenotype	0.85
Eating Time	modulates	phenotype	0.85
Shift Work	inhibits	phenotype	0.85
Social Jet Lag	inhibits	phenotype	0.85
Light	modulates	compound	0.85
Eating Time	associated_with	phenotype	0.85
Microbiome	associated_with	structure	0.82
PER2PROTEIN	participates_in	protein	0.80
BMAL1	participates_in	gene	0.80
PER	participates_in	gene	0.80
CRY	participates_in	gene	0.80
CLOCK	involved_in	gene	0.80
PER	involved_in	gene	0.80
Night-Time Light Exposure	inhibits	phenotype	0.80
Shift Work	associated_with	phenotype	0.80
Mistimed Eating	associated_with	phenotype	0.80
CLOCK	regulates	gene	0.80
GENES	regulates	gene	0.80
Als	associated_with	disease	0.80
OXIDATIVE STRESS	regulates	gene	0.80
CLOCK	regulates	gene	0.80
CIRCADIAN RHYTHM	associated_with	gene	0.80

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Circadian Rhythm Entrainment of Reactive Astrocytes	0.481	neurodegeneration	Astrocyte reactivity subtypes in neurode

Mentioning Analyses (2)

Scientific analyses that reference this entity

Is disrupted sleep a cause or consequence of neurodegeneration? Analyze the bidi

neurodegeneration | 2026-04-02 | 0 hypotheses

Is disrupted sleep a cause or consequence of neurodegeneration? Analyze the bidi

neurodegeneration | 2026-04-02 | 0 hypotheses

Experiments (4)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Astrocyte Ferritin Iron Metabolism Dysfunction in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Brainstem Circuit Modulation for PSP	clinical	ALS	0.400	0.50	human	proposed	$5,460,000
Non-Dopaminergic Neurotransmitter Degeneration in PD - Experiment Desi	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Proposed experiment from debate on Astrocytes adopt A1 (neurotoxic) an	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
BMAL1-HIF2A heterodimer modulates circadian variations of myocardial injury. [PMID:40269168]	Ruan W, Li T, Bang IH, Lee J, Deng W, Ma	Nature	2025	1
Obstructive sleep apnea syndrome, orexin, and sleep-wake cycle: The link with th [PMID:39864923]	Fernandes M, Liguori C	Handb Clin Neurol	2025	1
Circadian Influences on Brain Lipid Metabolism and Neurodegenerative Diseases. [PMID:39728504]	Hussain Y, Dar MI, Pan X	Metabolites	2024	1
Circadian rhythm regulates the function of immune cells and participates in the [PMID:38678017]	Zeng Y, Guo Z, Wu M, Chen F, Chen L	Cell Death Discov	2024	1
Circadian Clock Regulation on Lipid Metabolism and Metabolic Diseases. [PMID:32705594]	Pan X, Mota S, Zhang B	Adv Exp Med Biol	2020	1
BMAL1 attenuates myocardial infarction-induced fibrosis via suppressing p-SMAD3/ [PMID:41909150]	Zhang D, Wang H, Gu Z, Zhang L, Hu Z, Wa	Biochemistry and biophysics re	2026	0
Multifunctional hydrogel delivery of mesenchymal stem cell secretome suppresses [PMID:41092646]	Lin L, Liang X, Xu Z, Li Y, Guo Z et al.	Biomaterials	2026	0
The Liver Clock Tunes Transcriptional Rhythms in Skeletal Muscle to Regulate Mit [PMID:41486525]	Sica V, Sato T, Tsialtas I, Hernandez S,	J Biol Rhythms	2026	0
Glycaemic, appetite and circadian benefits of a dairy-enriched diet with high-pr [PMID:41578008]	Tsameret S, Froy O, Matz Y, Landau Z, Tw	Diabetologia	2026	0
Bmal1 Regulates Vascular Calcification via Noncanonical Circadian Pathway-Brief [PMID:41608773]	He M, Sun Y, Tang C, Huang F, Zhu Z et a	Arterioscler Thromb Vasc Biol	2026	0
Liver-specific knockout of CD73 exacerbated alcohol-associated steatohepatitis b [PMID:41833677]	Wu X, Zhang Q, Wang QQ, Liu ZN, Ni YY et	Int J Biol Macromol	2026	0
Adrenaline restores Bmal1 transcriptional rhythms dampened by SARS-CoV-2 infecti [PMID:41927871]	Suga K, Koizumi H, Asano Y, Hamasaki S,	Scientific reports	2026	0
Impact of acute blue light irradiation on the molecular clock and markers associ [PMID:41944887]	Vibriani A, Chen X, Kajiwara S, Orihara	J Mol Med (Berl)	2026	0
The clock out of sync: Insights into circadian disruption in wake-up vs non-wake [PMID:41945262]	Zhang X, Chen Z, Gu S, Zhu YL, Yu L et a	Adv Clin Exp Med	2026	0
Circadian disruption and its clinical implications in Parkinson's disease: A Nar [PMID:41905255]	Kataoka H, Saeki K, Sugie K, Obayashi K	Sleep medicine	2026	0
The neuroprotective role of eugenol against glyphosate-induced toxicity in rats: [PMID:41922126]	Bolat İ, Alat Ö, Orhan B, Dereli E, Teki	Tissue & cell	2026	0
Circadian abnormalities, molecular clock gene and chronobiological treatment for [PMID:41913359]	Chakraborty S, Srivastava V	Chronobiology international	2026	0
The rhythm of decline: Circadian disruption in neurodegeneration. [PMID:41066745]	Singh J, Kumar D, Kaur J, Singh A	Journal of food and drug analy	2025	0
Core Circadian Protein BMAL1: Implication for Nervous System Functioning and Its [PMID:41440117]	Smirnova KV, Smirnova LP, Amstislavskaya	Brain sciences	2025	0
Pharmacological targeting of BMAL1 modulates circadian and immune pathways. [PMID:40133642]	Pu H, Bailey LC, Bauer LG, Voronkov M, B	Nature chemical biology	2025	0

CIRCADIAN RHYTHM

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Sleep and Circadian Dysfunction in Alzheimer's Disease

CBS/PSP Supplements Guide

CBS/PSP Rehabilitation Master Guide

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Alzheimer's Disease Mechanism Index

Therapeutics

Alzheimer's Disease

Microglial Cells — Cell Type Hierarchy

GSK-3β in Neurodegeneration