Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about INSOMNIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | INSOMNIA |
| Key Genes/Proteins | circadian clock genes, OREXIN_A |
| Related Pathways | HPA_AXIS |
Knowledge base pages for this entity
graph TD
INSOMNIA["INSOMNIA"]
INSOMNIA -->|"contributes to"| Neurodegeneration["Neurodegeneration"]
INSOMNIA -->|"risk_factor_for"| Cardiovascular_Disease["Cardiovascular Disease"]
CIRCADIAN_CLOCK_GENES["CIRCADIAN CLOCK GENES"] -->|"causes"| INSOMNIA
Circadian_Clock_Genes["Circadian Clock Genes"] -->|"causes"| INSOMNIA
Circadian_Misalignment["Circadian Misalignment"] -->|"contributes to"| INSOMNIA
Melatonin["Melatonin"] -->|"treats"| INSOMNIA
Genetic_Polymorphisms["Genetic Polymorphisms"] -->|"risk_factor_for"| INSOMNIA
OREXIN_A["OREXIN-A"] -->|"regulates"| INSOMNIA
Mitochondrial_Oxidative_Stress["Mitochondrial Oxidative Stress"] -->|"contributes to"| INSOMNIA| Target | Relation | Type | Str |
|---|---|---|---|
| Mood Disorders | associated_with | disease | 0.90 |
| Metabolic Syndrome | risk_factor_for | disease | 0.90 |
| Cardiovascular Disease | risk_factor_for | disease | 0.85 |
| Neurodegeneration | contributes_to | process | 0.85 |
| Neurodegeneration | causes | process | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| circadian clock genes | implicated_in | gene | 0.80 |
| MSZRD | treats | drug | 0.72 |
| HPA_AXIS | associated_with | pathway | 0.64 |
| OREXIN_A | associated_with | protein | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||