gene

RNF14

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RNF14: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

89Connections

0Hypotheses

0Analyses

50Outgoing

34Incoming

Summary

RNF14 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, implicated in. Associated with Aging, Als, Cancer. Connected to 11 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RNF14
Full Name	Ring Finger Protein 14 (ARA54)
Chromosome	5q23.3
Protein Type	Ligase
Function	is a gene located on chromosome 5q23.
Primary Expression	Ubiquitously expressed; high expression in brain, testis, prostate
Amino Acids	511 aa
Exons	12
Pathways	ubiquitin-proteasome
UniProt ID	Q9Y2X9
NCBI Gene ID	9744
Ensembl ID	ENSG00000082630
OMIM	605423
GeneCards	RNF14
Human Protein Atlas	RNF14
Associated Diseases	ALS, Aging, Alzheimer
Interactions	UBIQUITIN, CCT4, ULK2, STXBP3, SORL1, SFPQ
KG Connections	89 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RNF14 — AlphaFold Q9Y2X9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RNF14["<b>RNF14</b>"]
    Ms{"Ms"}
    RNF14 -->|"activates"| Ms
    Aging{"Aging"}
    RNF14 -->|"associated with"| Aging
    UBIQUITIN["UBIQUITIN"]
    RNF14 -->|"associated with"| UBIQUITIN
    neurodegeneration["neurodegeneration"]
    RNF14 -->|"implicated in"| neurodegeneration
    AND["AND"]
    AND -->|"associated with"| RNF14
    style RNF14 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (55)

Target	Relation	Type	Str
EEF1A	associated_with	entity	0.95
Ms	activates	disease	0.65
Aging	associated_with	disease	0.65
Cancer	activates	disease	0.65
Aging	activates	disease	0.65
Als	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Aging	degrades	disease	0.65
UBIQUITIN	associated_with	gene	0.60
UBIQUITIN	activates	gene	0.60
ULK2	associated_with	gene	0.60
SSBP1	associated_with	gene	0.60
SYNCRIP	associated_with	gene	0.60
STXBP3	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
IDS	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
APP	associated_with	gene	0.60
CCT4	associated_with	gene	0.60
SFPQ	associated_with	gene	0.60
SMARCB1	associated_with	gene	0.60
SYNE2	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
TMEM59	associated_with	gene	0.60
UBIQUITIN	degrades	gene	0.60
APOE	associated_with	gene	0.60
PRDX3	associated_with	gene	0.60
SMARCB1	interacts_with	gene	0.60
SSBP1	interacts_with	gene	0.60
SYNE2	interacts_with	gene	0.60
TMEM59	interacts_with	gene	0.60
CANCER	activates	gene	0.60
AGING	activates	gene	0.60
DNA	activates	gene	0.60
COPA	associated_with	gene	0.60
AND	associated_with	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
App	degrades	protein	0.60
Igf	associated_with	protein	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
Alzheimer's disease	interacts_with	disease	0.60
CCT4	interacts_with	gene	0.50
ULK2	interacts_with	gene	0.50
STXBP3	interacts_with	gene	0.50
SORL1	interacts_with	gene	0.50
SFPQ	interacts_with	protein	0.50
IGF2R	interacts_with	protein	0.50

Incoming (34)

Source	Relation	Type	Str
GCN1	interacts_with	entity	0.92
UBIQUITIN	associated_with	gene	0.60
IDS	associated_with	gene	0.60
SYNCRIP	associated_with	gene	0.60
SSBP1	associated_with	gene	0.60
PRDX3	associated_with	gene	0.60
APP	associated_with	gene	0.60
APOE	associated_with	gene	0.60
SYNE2	associated_with	gene	0.60
SMARCB1	associated_with	gene	0.60
ULK2	associated_with	gene	0.60
TMEM59	associated_with	gene	0.60
SFPQ	associated_with	gene	0.60
CCT4	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
STXBP3	associated_with	gene	0.60
UBIQUITIN	degrades	gene	0.60
APP	interacts_with	gene	0.60
CCT4	interacts_with	gene	0.60
IDS	interacts_with	gene	0.60
IGF2R	interacts_with	gene	0.60
AND	degrades	gene	0.60
ALZHEIMER	associated_with	gene	0.60
COPA	associated_with	gene	0.60
COPA	interacts_with	gene	0.60
APOE	interacts_with	gene	0.50
SYNE2	interacts_with	gene	0.50
SMARCB1	interacts_with	gene	0.50
TMEM59	interacts_with	gene	0.50
PRDX3	interacts_with	gene	0.50
SSBP1	interacts_with	gene	0.50
CALB1	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

RNF14

Understanding Entity Pages

Summary

Wiki Pages (7)

RNF14 — Ring Finger Protein 14

E3 Ubiquitin Ligase System in Neurodegeneration

IDS — Iduronate Sulfatase

SYNE2 Gene

UBE2A Gene