Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IL32: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
IL32 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Inflammation, Psoriasis. Connected to 17 entities in the SciDEX knowledge graph.
| Gene Symbol | IL32 |
| Chromosome | 16p13.3 |
| Function | is a pro-inflammatory cytokine originally identified based on its elevated expression in activated natural killer (NK) cells and T cells [1/https://pubmed. |
| Primary Expression | various cell types including T cells, NK cells, monocytes, epithelial cells, and endothelial cells |
| Pathways | Apoptosis, Necroptosis |
| Ensembl ID | ENSG00000127124 |
| GeneCards | IL32 |
| Human Protein Atlas | IL32 |
| gene = IL32 | name = Interleukin 32 |
| ncbi_gene_id = 9235 | ensembl = ENSG00000127124 |
| TNFR1/2 | Receptor binding |
| IL-6R | Cytokine cross-talk |
| PKR | Apoptosis induction |
| TLR3 | Viral recognition |
| Caspase-1 | Inflammasome |
| Associated Diseases | neurodegeneration |
| Interactions | TNF, DAPK1, RIPK3, CXCL10, APOPTOSIS, INFLAMMATION |
| KG Connections | 16 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
IL32["IL32"]
Inflammation{"Inflammation"}
IL32 -->|"activates"| Inflammation
Psoriasis{"Psoriasis"}
IL32 -->|"activates"| Psoriasis
APOPTOSIS["APOPTOSIS"]
IL32 -->|"activates"| APOPTOSIS
TNF["TNF"]
IL32 -->|"activates"| TNF
DAPK1["DAPK1"]
IL32 -->|"activates"| DAPK1
INFLAMMATION["INFLAMMATION"]
IL32 -->|"activates"| INFLAMMATION
RIPK3["RIPK3"]
IL32 -->|"activates"| RIPK3
CCL2["CCL2"]
IL32 -->|"activates"| CCL2
GENES["GENES"]
IL32 -->|"activates"| GENES
CXCL11["CXCL11"]
IL32 -->|"activates"| CXCL11
CXCL10["CXCL10"]
IL32 -->|"activates"| CXCL10
CXCL9["CXCL9"]
IL32 -->|"activates"| CXCL9
IFN["IFN"]
IL32 -->|"activates"| IFN
Apoptosis(["Apoptosis"])
IL32 -->|"activates"| Apoptosis
Necroptosis(["Necroptosis"])
IL32 -->|"activates"| Necroptosis| Target | Relation | Type | Str |
|---|---|---|---|
| Inflammation | activates | disease | 0.65 |
| Psoriasis | activates | disease | 0.65 |
| TNF | activates | gene | 0.60 |
| DAPK1 | activates | gene | 0.60 |
| RIPK3 | activates | gene | 0.60 |
| CXCL10 | activates | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| CCL2 | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| CXCL11 | activates | gene | 0.60 |
| CXCL9 | activates | gene | 0.60 |
| IFN | activates | gene | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| Necroptosis | activates | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BAX | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||