gene

IL32

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL32: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections
0Hypotheses
0Analyses
15Outgoing
1Incoming

Summary

IL32 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Inflammation, Psoriasis. Connected to 17 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolIL32
Chromosome16p13.3
Functionis a pro-inflammatory cytokine originally identified based on its elevated expression in activated natural killer (NK) cells and T cells [1/https://pubmed.
Primary Expressionvarious cell types including T cells, NK cells, monocytes, epithelial cells, and endothelial cells
PathwaysApoptosis, Necroptosis
Ensembl IDENSG00000127124
GeneCardsIL32
Human Protein AtlasIL32
gene = IL32name = Interleukin 32
ncbi_gene_id = 9235ensembl = ENSG00000127124
TNFR1/2Receptor binding
IL-6RCytokine cross-talk
PKRApoptosis induction
TLR3Viral recognition
Caspase-1Inflammasome
Associated Diseasesneurodegeneration
InteractionsTNF, DAPK1, RIPK3, CXCL10, APOPTOSIS, INFLAMMATION
KG Connections16 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

IL32

gene · 3130 words

Genes

index · 271 words

Pathway Diagram

graph TD
    IL32["IL32"]
    Inflammation{"Inflammation"}
    IL32 -->|"activates"| Inflammation
    Psoriasis{"Psoriasis"}
    IL32 -->|"activates"| Psoriasis
    APOPTOSIS["APOPTOSIS"]
    IL32 -->|"activates"| APOPTOSIS
    TNF["TNF"]
    IL32 -->|"activates"| TNF
    DAPK1["DAPK1"]
    IL32 -->|"activates"| DAPK1
    INFLAMMATION["INFLAMMATION"]
    IL32 -->|"activates"| INFLAMMATION
    RIPK3["RIPK3"]
    IL32 -->|"activates"| RIPK3
    CCL2["CCL2"]
    IL32 -->|"activates"| CCL2
    GENES["GENES"]
    IL32 -->|"activates"| GENES
    CXCL11["CXCL11"]
    IL32 -->|"activates"| CXCL11
    CXCL10["CXCL10"]
    IL32 -->|"activates"| CXCL10
    CXCL9["CXCL9"]
    IL32 -->|"activates"| CXCL9
    IFN["IFN"]
    IL32 -->|"activates"| IFN
    Apoptosis(["Apoptosis"])
    IL32 -->|"activates"| Apoptosis
    Necroptosis(["Necroptosis"])
    IL32 -->|"activates"| Necroptosis

Outgoing (15)

TargetRelationTypeStr
Inflammationactivatesdisease0.65
Psoriasisactivatesdisease0.65
TNFactivatesgene0.60
DAPK1activatesgene0.60
RIPK3activatesgene0.60

Incoming (1)

SourceRelationTypeStr
BAXactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found