gene

DAPK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DAPK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

191Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

Death-Associated Protein Kinase 1 - calcium/calmodulin-dependent kinase implicated in Alzheimer's disease, Parkinson's disease, and stroke through regulation of apoptosis, autophagy, and alpha-synuclein phosphorylation.

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🧬 Gene Info

Gene Symbol	DAPK1
Full Name	Death-Associated Protein Kinase 1
Chromosome	9p21.3
Protein Family	CaMK (Calcium/Calmodulin-dependent protein kinase) family
Protein Type	Serine/Threonine Kinase
Function	encodes a calcium/calmodulin-dependent serine/threonine kinase that functions as a positive regulator of apoptosis, autophagy, and programmed cell death.
Primary Expression	the brain, particularly in neurons, where it integrates calcium signaling with cell death pathways
Subcellular Localization	and interactions
Molecular Weight	160 kDa
Amino Acids	1056 aa
Pathways	PI3K
UniProt ID	P53355
NCBI Gene ID	1612
Ensembl ID	ENSG00000196730
OMIM	600730
GeneCards	DAPK1
Human Protein Atlas	DAPK1
Associated Diseases	AD, ALS, AMI, Alzheimer, Alzheimer's disease
Interactions	HSPG2, IL1B, APP, EIF2AK2, HMGCR, PARP1
SciDEX Hypotheses	DAPK1 Inhibition as Dual-Mechanism Neuroprotection
KG Connections	191 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DAPK1 — AlphaFold P53355 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DAPK1["DAPK1"] -->|"interacts"| Alzheimer["Alzheimer"]
    DAPK1["DAPK1"] -->|"activates"| Tumor["Tumor"]
    DAPK1["DAPK1"] -->|"interacts"| Als["Als"]
    DAPK1["DAPK1"] -->|"interacts"| Ischemia["Ischemia"]
    DAPK1["DAPK1"] -->|"interacts"| ALS["ALS"]
    DAPK1["DAPK1"] -->|"interacts"| HSPG2["HSPG2"]
    NCSTN["NCSTN"] -->|"interacts"| DAPK1["DAPK1"]
    FAS["FAS"] -->|"activates"| DAPK1["DAPK1"]
    TNF["TNF"] -->|"activates"| DAPK1["DAPK1"]
    LMNA["LMNA"] -->|"interacts"| DAPK1["DAPK1"]
    style DAPK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (119)

Target	Relation	Type	Str
CDKN2A	regulates	gene	0.80
REDD1	regulates	gene	0.80
FOXO1	regulates	gene	0.80
FASL	regulates	gene	0.80
Alzheimer	interacts_with	disease	0.65
Tumor	activates	disease	0.65
Als	interacts_with	disease	0.65
Ischemia	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Stroke	activates	disease	0.65
Als	activates	disease	0.65
Ischemia	activates	disease	0.65
Inflammation	implicated_in	disease	0.65
Psoriasis	expressed_in	disease	0.65
Aging	regulates	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Als	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
Parkinson	causes	disease	0.65
ALS	causes	disease	0.65
Neurodegeneration	causes	disease	0.65
HSPG2	interacts_with	gene	0.60
IL1B	activates	gene	0.60
APP	interacts_with	gene	0.60
EIF2AK2	interacts_with	gene	0.60
HMGCR	interacts_with	gene	0.60
PARP1	activates	gene	0.60
TNF	activates	gene	0.60
NCSTN	interacts_with	gene	0.60
PSEN2	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
A2M	interacts_with	gene	0.60
IL6	activates	gene	0.60
SREBF1	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
FAS	activates	gene	0.60
PEN2	interacts_with	gene	0.60
APH1B	interacts_with	gene	0.60
PSEN1	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
BECN1	activates	gene	0.60
BNIP3L	activates	gene	0.60
PINK1	activates	gene	0.60
DYNEIN	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
P38	activates	gene	0.60
AKT	activates	gene	0.60

Incoming (72)

Source	Relation	Type	Str
TNF	activates	gene	0.70
NCSTN	interacts_with	gene	0.60
FAS	activates	gene	0.60
LMNA	interacts_with	gene	0.60
APH1B	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
IL6	activates	gene	0.60
SREBF1	interacts_with	gene	0.60
PSEN2	interacts_with	gene	0.60
A2M	interacts_with	gene	0.60
DHCR24	interacts_with	gene	0.60
HMGCR	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
PARP1	activates	gene	0.60
PEN2	interacts_with	gene	0.60
PSEN1	interacts_with	gene	0.60
EIF2AK2	interacts_with	gene	0.60
IL1B	activates	gene	0.60
BCL2	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
DYNEIN	interacts_with	gene	0.60
PP2A	therapeutic_target	gene	0.60
PTEN	activates	gene	0.60
CDK5	activates	gene	0.60
JNK	activates	gene	0.60
PSD95	activates	gene	0.60
BAX	activates	gene	0.60
IL32	activates	gene	0.60
FAS	regulates	gene	0.60
FOXO1	activates	gene	0.60
CDKN2A	activates	gene	0.60
HSPG2	interacts_with	gene	0.60
H2AX	causes	gene	0.60
DCAF17	activates	gene	0.60
PINK1	causes	gene	0.60
SNCA	activates	gene	0.60
UBIQUITIN	causes	gene	0.60
DCTN5	activates	gene	0.60
UBIQUITIN	inhibits	gene	0.60
P62	inhibits	gene	0.60
H2AX	inhibits	gene	0.60
ATM	regulates	gene	0.60
APP	regulates	gene	0.60
CDK5	regulates	gene	0.60
MITOCHONDRIAL DNA	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
APOPTOSIS	activates	gene	0.60
AMYLOID	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
DAPK1 Inhibition as Dual-Mechanism Neuroprotection Against T	0.579	neurodegeneration	Should microtubule-stabilizing drugs be

Mentioning Analyses (1)

Scientific analyses that reference this entity

Should microtubule-stabilizing drugs be reconsidered as therapeutic targets for

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.609

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DAPK1

Understanding Entity Pages

Summary

Wiki Pages (21)

DAPK1 Gene

calcium-dysregulation-comparison

er-stress-neurodegeneration

Tau Kinase Signaling Cascade in Alzheimer's Disease

Epigenetics in Amyotrophic Lateral Sclerosis

LRRK2 Pathway in PD

UNC5C — Unc-5 Netrin Receptor C

PRKAA2 (AMPKα2) — AMP-Activated Protein Kinase Catalytic Subunit Alpha 2

AMBRA1 Gene

A2M Gene

cdkn2a

PEN2 Protein

LRRK2 Inhibitor Therapy

UNC-5B Protein

PARP1 (Poly(ADP-Ribose) Polymerase 1)

DAPK1 Protein

Cullin-3 — Protein

CUL3 — Cullin 3

Presenilin Enhancer 2 (PEN-2) Protein