Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KIF20A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Gene profile: KIF20A (MKLP2), a kinesin-6 motor protein involved in cytokinesis, intracellular transport, and golgi dynamics
| Gene Symbol | KIF20A |
| Full Name | Kinesin Family Member 20A (MKLP2) |
| Aliases | MKLP2, Kinesin Family Member 20A |
| Chromosome | 5q31.2 |
| Protein Family | Kinesin-6 (MKLP) subfamily |
| Function | encodes a protein of 878 amino acids belonging to the kinesin-6 family, also known as the MKLP2 (Mitotic Kinesin-Like Protein 2) subfamily. |
| Primary Expression | Mitotic cells, Golgi apparatus |
| Molecular Weight | ~100 kDa |
| Amino Acids | 878 aa |
| Exons | 28 |
| UniProt ID | O95237 |
| NCBI Gene ID | 9788 |
| GeneCards | KIF20A |
| Human Protein Atlas | KIF20A |
| Associated Diseases | neurodegeneration |
| Interactions | UBIQUITIN, CD8, CANCER |
| KG Connections | 24 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
KIF20A["<b>KIF20A</b>"]
Hepatitis{"Hepatitis"}
KIF20A -->|"therapeutic target"| Hepatitis
Als{"Als"}
KIF20A -->|"interacts with"| Als
Ms{"Ms"}
KIF20A -->|"interacts with"| Ms
Cancer{"Cancer"}
KIF20A -->|"interacts with"| Cancer
Tumor{"Tumor"}
KIF20A -->|"interacts with"| Tumor
G6PD["G6PD"]
KIF20A -->|"associated with"| G6PD
MCC["MCC"]
KIF20A -->|"therapeutic target"| MCC
FERROPTOSIS["FERROPTOSIS"]
KIF20A -->|"therapeutic target"| FERROPTOSIS
AUTOPHAGY["AUTOPHAGY"]
KIF20A -->|"therapeutic target"| AUTOPHAGY
SLC7A11["SLC7A11"]
KIF20A -->|"associated with"| SLC7A11
SPP1["SPP1"]
KIF20A -->|"associated with"| SPP1
IRS1["IRS1"]
KIF20A -->|"associated with"| IRS1
HMOX1["HMOX1"]
HMOX1 -->|"associated with"| KIF20A
IGF1["IGF1"]
IGF1 -->|"associated with"| KIF20A
style KIF20A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Hepatitis | therapeutic_target | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Cancer | interacts_with | disease | 0.65 |
| Tumor | interacts_with | disease | 0.65 |
| MCC | therapeutic_target | gene | 0.60 |
| SLC7A11 | associated_with | gene | 0.60 |
| SPP1 | associated_with | gene | 0.60 |
| UBIQUITIN | interacts_with | gene | 0.60 |
| CD8 | interacts_with | gene | 0.60 |
| HSP90AB1 | associated_with | gene | 0.60 |
| KIF4A | associated_with | gene | 0.60 |
| JUN | associated_with | gene | 0.60 |
| G6PD | associated_with | gene | 0.60 |
| FERROPTOSIS | therapeutic_target | gene | 0.60 |
| AUTOPHAGY | therapeutic_target | gene | 0.60 |
| IRS1 | associated_with | gene | 0.60 |
| AUTOPHAGY-RELATED GENES | therapeutic_target | gene | 0.60 |
| Ferroptosis | therapeutic_target | pathway | 0.60 |
| Autophagy | therapeutic_target | pathway | 0.60 |
| Immune Response | therapeutic_target | pathway | 0.60 |
| CANCER | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||