gene

KIF20A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KIF20A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

24Connections
0Hypotheses
0Analyses
22Outgoing
2Incoming

Summary

Gene profile: KIF20A (MKLP2), a kinesin-6 motor protein involved in cytokinesis, intracellular transport, and golgi dynamics

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🧬 Gene Info
Gene SymbolKIF20A
Full NameKinesin Family Member 20A (MKLP2)
AliasesMKLP2, Kinesin Family Member 20A
Chromosome5q31.2
Protein FamilyKinesin-6 (MKLP) subfamily
Functionencodes a protein of 878 amino acids belonging to the kinesin-6 family, also known as the MKLP2 (Mitotic Kinesin-Like Protein 2) subfamily.
Primary ExpressionMitotic cells, Golgi apparatus
Molecular Weight~100 kDa
Amino Acids878 aa
Exons28
UniProt IDO95237
NCBI Gene ID9788
GeneCardsKIF20A
Human Protein AtlasKIF20A
Associated Diseasesneurodegeneration
InteractionsUBIQUITIN, CD8, CANCER
KG Connections24 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: KIF20A — AlphaFold O95237 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

KIF20A — Kinesin Family Member 20A

gene · 643 words

Parkinson's Disease

disease · 8807 words

Alzheimer's Disease

disease · 5265 words

Axonal Transport

mechanism · 1546 words

Cytoskeletal Dynamics and Axonal Transport Pathway

mechanism · 1129 words

KIF20B — Kinesin Family Member 20B

gene · 644 words

Pathway Diagram

graph TD
    KIF20A["<b>KIF20A</b>"]
    Hepatitis{"Hepatitis"}
    KIF20A -->|"therapeutic target"| Hepatitis
    Als{"Als"}
    KIF20A -->|"interacts with"| Als
    Ms{"Ms"}
    KIF20A -->|"interacts with"| Ms
    Cancer{"Cancer"}
    KIF20A -->|"interacts with"| Cancer
    Tumor{"Tumor"}
    KIF20A -->|"interacts with"| Tumor
    G6PD["G6PD"]
    KIF20A -->|"associated with"| G6PD
    MCC["MCC"]
    KIF20A -->|"therapeutic target"| MCC
    FERROPTOSIS["FERROPTOSIS"]
    KIF20A -->|"therapeutic target"| FERROPTOSIS
    AUTOPHAGY["AUTOPHAGY"]
    KIF20A -->|"therapeutic target"| AUTOPHAGY
    SLC7A11["SLC7A11"]
    KIF20A -->|"associated with"| SLC7A11
    SPP1["SPP1"]
    KIF20A -->|"associated with"| SPP1
    IRS1["IRS1"]
    KIF20A -->|"associated with"| IRS1
    HMOX1["HMOX1"]
    HMOX1 -->|"associated with"| KIF20A
    IGF1["IGF1"]
    IGF1 -->|"associated with"| KIF20A
    style KIF20A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (22)

TargetRelationTypeStr
Hepatitistherapeutic_targetdisease0.65
Alsinteracts_withdisease0.65
Msinteracts_withdisease0.65
Cancerinteracts_withdisease0.65
Tumorinteracts_withdisease0.65

Incoming (2)

SourceRelationTypeStr
HMOX1associated_withgene0.60
IGF1associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found