Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MGLUR5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | MGLUR5 |
| Protein Type | Receptor |
| Function | mGluR5 is a Group I metabotropic glutamate receptor that activates PLC signaling and plays roles in learning, memory, and pain perception. |
| Molecular Weight | 127 kDa |
| GeneCards | MGLUR5 |
| Human Protein Atlas | MGLUR5 |
| Associated Diseases | Epilepsy |
| KG Connections | 34 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
MGLUR5["<b>MGLUR5</b>"]
Astrocytes["Astrocytes"]
MGLUR5 -->|"expressed in"| Astrocytes
Epilepsy["Epilepsy"]
MGLUR5 -->|"associated with"| Epilepsy
P2RY2["P2RY2"]
MGLUR5 -->|"associated with"| P2RY2
EPILEPSY["EPILEPSY"]
MGLUR5 -->|"associated with"| EPILEPSY
MGLUR1["MGLUR1"]
MGLUR5 -->|"regulates"| MGLUR1
PER["PER"]
MGLUR5 -->|"associated with"| PER
AND["AND"]
MGLUR5 -->|"regulates"| AND
ASTROCYTES["ASTROCYTES"]
MGLUR5 -->|"associated with"| ASTROCYTES
CD68["CD68"]
MGLUR5 -->|"associated with"| CD68
NEURON["NEURON"]
MGLUR5 -->|"associated with"| NEURON
MICROGLIA["MICROGLIA"]
MGLUR5 -->|"associated with"| MICROGLIA
P2RY1["P2RY1"]
P2RY1 -->|"associated with"| MGLUR5
SYNAPSE["SYNAPSE"]
SYNAPSE -->|"associated with"| MGLUR5
ASTROCYTE["ASTROCYTE"]
ASTROCYTE -->|"associated with"| MGLUR5
EPILEPSY["EPILEPSY"]
EPILEPSY -->|"associated with"| MGLUR5
ASTROCYTE["ASTROCYTE"]
ASTROCYTE -->|"regulates"| MGLUR5
Astrocyte["Astrocyte"]
MGLUR5 -->|"expressed in"| Astrocyte
Neuron["Neuron"]
MGLUR5 -->|"expressed in"| Neuron
Microglia["Microglia"]
MGLUR5 -->|"expressed in"| Microglia
Astrocyte["Astrocyte"]
MGLUR5 -->|"regulates"| Astrocyte
GLIOSIS["GLIOSIS"]
MGLUR5 -->|"regulates"| GLIOSIS
P2RY1["P2RY1"]
P2RY1 -->|"regulates"| MGLUR5
P2RY2["P2RY2"]
P2RY2 -->|"regulates"| MGLUR5
MGLUR1["MGLUR1"]
MGLUR1 -->|"regulates"| MGLUR5
P2RY2["P2RY2"]
P2RY2 -->|"associated with"| MGLUR5
MGLUR1["MGLUR1"]
MGLUR1 -->|"associated with"| MGLUR5
EPILEPSY["EPILEPSY"]
EPILEPSY -->|"regulates"| MGLUR5
neurodegeneration["neurodegeneration"]
MGLUR5 -->|"implicated in"| neurodegeneration| Target | Relation | Type | Str |
|---|---|---|---|
| Epilepsy | associated_with | disease | 0.65 |
| P2RY2 | associated_with | gene | 0.60 |
| MGLUR1 | regulates | gene | 0.60 |
| CD68 | associated_with | gene | 0.60 |
| P2RY1 | associated_with | gene | 0.60 |
| EPILEPSY | associated_with | gene | 0.60 |
| PER | associated_with | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| ASTROCYTES | associated_with | gene | 0.60 |
| NEURON | associated_with | gene | 0.60 |
| MICROGLIA | associated_with | gene | 0.60 |
| Astrocyte | associated_with | cell_type | 0.60 |
| Microglia | associated_with | cell_type | 0.60 |
| Neuron | associated_with | cell_type | 0.60 |
| SYNAPSE | associated_with | gene | 0.60 |
| Astrocyte | expressed_in | cell_type | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
| Microglia | expressed_in | cell_type | 0.55 |
| Astrocyte | regulates | cell_type | 0.50 |
| GLIOSIS | regulates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| P2RY1 | associated_with | gene | 0.60 |
| SYNAPSE | associated_with | gene | 0.60 |
| ASTROCYTE | associated_with | gene | 0.60 |
| EPILEPSY | associated_with | gene | 0.60 |
| ASTROCYTE | regulates | gene | 0.60 |
| PER | associated_with | gene | 0.60 |
| ASTROCYTES | associated_with | gene | 0.60 |
| MICROGLIA | associated_with | gene | 0.60 |
| P2RY1 | regulates | gene | 0.50 |
| P2RY2 | regulates | gene | 0.50 |
| MGLUR1 | regulates | protein | 0.50 |
| P2RY2 | associated_with | gene | 0.50 |
| MGLUR1 | associated_with | protein | 0.50 |
| EPILEPSY | regulates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||