protein

MGLUR5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MGLUR5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections

0Hypotheses

2Analyses

21Outgoing

17Incoming

0Experiments

2Debates

Summary

Page for mGluR5 Protein

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🔬 Protein Info

Gene Symbol	MGLUR5
Protein Type	Receptor
Function	mGluR5 is a Group I metabotropic glutamate receptor that activates PLC signaling and plays roles in learning, memory, and pain perception.
Molecular Weight	127 kDa
GeneCards	MGLUR5
Human Protein Atlas	MGLUR5
Associated Diseases	Epilepsy, tau_pathology
KG Connections	34 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

mGluR5 Protein

protein · 726 words

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Pathway Diagram

graph TD
    MGLUR5["MGLUR5"]
    Astrocytes["Astrocytes"]
    MGLUR5 -->|"expressed in"| Astrocytes
    Epilepsy["Epilepsy"]
    MGLUR5 -->|"associated with"| Epilepsy
    P2RY2["P2RY2"]
    MGLUR5 -->|"associated with"| P2RY2
    EPILEPSY["EPILEPSY"]
    MGLUR5 -->|"associated with"| EPILEPSY
    MGLUR1["MGLUR1"]
    MGLUR5 -->|"regulates"| MGLUR1
    PER["PER"]
    MGLUR5 -->|"associated with"| PER
    AND["AND"]
    MGLUR5 -->|"regulates"| AND
    ASTROCYTES["ASTROCYTES"]
    MGLUR5 -->|"associated with"| ASTROCYTES
    CD68["CD68"]
    MGLUR5 -->|"associated with"| CD68
    NEURON["NEURON"]
    MGLUR5 -->|"associated with"| NEURON
    MICROGLIA["MICROGLIA"]
    MGLUR5 -->|"associated with"| MICROGLIA
    P2RY1["P2RY1"]
    P2RY1 -->|"associated with"| MGLUR5
    SYNAPSE["SYNAPSE"]
    SYNAPSE -->|"associated with"| MGLUR5
    ASTROCYTE["ASTROCYTE"]
    ASTROCYTE -->|"associated with"| MGLUR5
    EPILEPSY["EPILEPSY"]
    EPILEPSY -->|"associated with"| MGLUR5
    ASTROCYTE["ASTROCYTE"]
    ASTROCYTE -->|"regulates"| MGLUR5
    Astrocyte["Astrocyte"]
    MGLUR5 -->|"expressed in"| Astrocyte
    Neuron["Neuron"]
    MGLUR5 -->|"expressed in"| Neuron
    Microglia["Microglia"]
    MGLUR5 -->|"expressed in"| Microglia
    Astrocyte["Astrocyte"]
    MGLUR5 -->|"regulates"| Astrocyte
    GLIOSIS["GLIOSIS"]
    MGLUR5 -->|"regulates"| GLIOSIS
    P2RY1["P2RY1"]
    P2RY1 -->|"regulates"| MGLUR5
    P2RY2["P2RY2"]
    P2RY2 -->|"regulates"| MGLUR5
    MGLUR1["MGLUR1"]
    MGLUR1 -->|"regulates"| MGLUR5
    P2RY2["P2RY2"]
    P2RY2 -->|"associated with"| MGLUR5
    MGLUR1["MGLUR1"]
    MGLUR1 -->|"associated with"| MGLUR5
    EPILEPSY["EPILEPSY"]
    EPILEPSY -->|"regulates"| MGLUR5
    neurodegeneration["neurodegeneration"]
    MGLUR5 -->|"implicated in"| neurodegeneration

Outgoing (21)

Target	Relation	Type	Str
Epilepsy	associated_with	disease	0.65
Astrocyte	associated_with	cell_type	0.60
Microglia	associated_with	cell_type	0.60
PER	associated_with	gene	0.60
ASTROCYTES	associated_with	gene	0.60
MGLUR1	regulates	gene	0.60
NEURON	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
P2RY2	associated_with	gene	0.60
EPILEPSY	associated_with	gene	0.60
Neuron	associated_with	cell_type	0.60
SYNAPSE	associated_with	gene	0.60
CD68	associated_with	gene	0.60
P2RY1	associated_with	gene	0.60
Neuron	expressed_in	cell_type	0.55
Astrocyte	expressed_in	cell_type	0.55
Microglia	expressed_in	cell_type	0.55
GLIOSIS	regulates	concept	0.50
Astrocyte	regulates	cell_type	0.50
Amyloid-beta oligomers	interacts_with	protein	0.50
tau_pathology	associated_with	disease	0.50

Incoming (17)

Source	Relation	Type	Str
29062097	is significantly more mobile at	paper	0.90
ABETA	binds_to	protein	0.80
ADORA2B	downregulates	receptor	0.80
P2RY1	associated_with	gene	0.60
SYNAPSE	associated_with	gene	0.60
ASTROCYTE	associated_with	gene	0.60
EPILEPSY	associated_with	gene	0.60
ASTROCYTE	regulates	gene	0.60
PER	associated_with	gene	0.60
ASTROCYTES	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
EPILEPSY	regulates	gene	0.50
P2RY1	regulates	gene	0.50
P2RY2	regulates	gene	0.50
MGLUR1	regulates	protein	0.50
P2RY2	associated_with	gene	0.50
MGLUR1	associated_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

How can functional hyperconnectivity patterns distinguish compensatory mechanism

neurodegeneration | 2026-04-13 | 0 hypotheses

Do tau aggregates represent protective responses or primary pathogenic drivers i

neurodegeneration | 2026-04-11 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

The debate highlighted fundamental disagreement about tau's role - whether aggre

closed · Rounds: 4 · Score: 1.00 · 2026-04-20

The debate framework identified functional hyperconnectivity as potentially repr

closed · Rounds: 4 · Score: 0.95 · 2026-04-16

Related Research

Hypotheses and analyses mentioning MGLUR5 in their description or question text

No additional research found