protein

MGLUR5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MGLUR5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

36Connections
0Hypotheses
0Analyses
20Outgoing
14Incoming

Summary

Page for mGluR5 Protein

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🔬 Protein Info
Gene SymbolMGLUR5
Protein TypeReceptor
FunctionmGluR5 is a Group I metabotropic glutamate receptor that activates PLC signaling and plays roles in learning, memory, and pain perception.
Molecular Weight127 kDa
GeneCardsMGLUR5
Human Protein AtlasMGLUR5
Associated DiseasesEpilepsy
KG Connections34 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

mGluR5 Protein

redirect · 579 words

cbs-psp-daily-action-plan

therapeutic · 30834 words

GRIA3 Gene

gene · 5408 words

Huntington's Disease

disease · 4606 words

PMN310 Anti-Amyloid for AD (NCT06750432)

clinical · 4244 words

Excitotoxicity in Neurodegeneration

mechanism · 4129 words

Pathway Diagram

graph TD
    MGLUR5["<b>MGLUR5</b>"]
    Astrocytes["Astrocytes"]
    MGLUR5 -->|"expressed in"| Astrocytes
    Epilepsy["Epilepsy"]
    MGLUR5 -->|"associated with"| Epilepsy
    P2RY2["P2RY2"]
    MGLUR5 -->|"associated with"| P2RY2
    EPILEPSY["EPILEPSY"]
    MGLUR5 -->|"associated with"| EPILEPSY
    MGLUR1["MGLUR1"]
    MGLUR5 -->|"regulates"| MGLUR1
    PER["PER"]
    MGLUR5 -->|"associated with"| PER
    AND["AND"]
    MGLUR5 -->|"regulates"| AND
    ASTROCYTES["ASTROCYTES"]
    MGLUR5 -->|"associated with"| ASTROCYTES
    CD68["CD68"]
    MGLUR5 -->|"associated with"| CD68
    NEURON["NEURON"]
    MGLUR5 -->|"associated with"| NEURON
    MICROGLIA["MICROGLIA"]
    MGLUR5 -->|"associated with"| MICROGLIA
    P2RY1["P2RY1"]
    P2RY1 -->|"associated with"| MGLUR5
    SYNAPSE["SYNAPSE"]
    SYNAPSE -->|"associated with"| MGLUR5
    ASTROCYTE["ASTROCYTE"]
    ASTROCYTE -->|"associated with"| MGLUR5
    EPILEPSY["EPILEPSY"]
    EPILEPSY -->|"associated with"| MGLUR5
    ASTROCYTE["ASTROCYTE"]
    ASTROCYTE -->|"regulates"| MGLUR5
    Astrocyte["Astrocyte"]
    MGLUR5 -->|"expressed in"| Astrocyte
    Neuron["Neuron"]
    MGLUR5 -->|"expressed in"| Neuron
    Microglia["Microglia"]
    MGLUR5 -->|"expressed in"| Microglia
    Astrocyte["Astrocyte"]
    MGLUR5 -->|"regulates"| Astrocyte
    GLIOSIS["GLIOSIS"]
    MGLUR5 -->|"regulates"| GLIOSIS
    P2RY1["P2RY1"]
    P2RY1 -->|"regulates"| MGLUR5
    P2RY2["P2RY2"]
    P2RY2 -->|"regulates"| MGLUR5
    MGLUR1["MGLUR1"]
    MGLUR1 -->|"regulates"| MGLUR5
    P2RY2["P2RY2"]
    P2RY2 -->|"associated with"| MGLUR5
    MGLUR1["MGLUR1"]
    MGLUR1 -->|"associated with"| MGLUR5
    EPILEPSY["EPILEPSY"]
    EPILEPSY -->|"regulates"| MGLUR5
    neurodegeneration["neurodegeneration"]
    MGLUR5 -->|"implicated in"| neurodegeneration

Outgoing (20)

TargetRelationTypeStr
Epilepsyassociated_withdisease0.65
P2RY2associated_withgene0.60
MGLUR1regulatesgene0.60
CD68associated_withgene0.60
P2RY1associated_withgene0.60

Incoming (16)

SourceRelationTypeStr
P2RY1associated_withgene0.60
SYNAPSEassociated_withgene0.60
ASTROCYTEassociated_withgene0.60
EPILEPSYassociated_withgene0.60
ASTROCYTEregulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found