Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about P2RY2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
P2RY2 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, implicated in. Associated with Aging, Inflammation, Ms. Connected to 31 entities in the SciDEX knowledge graph.
| Gene Symbol | P2RY2 |
| Full Name | Purinergic Receptor P2Y2 |
| Chromosome | 11 |
| Protein Family | P2Y receptor family (GPCR) |
| Protein Type | Receptor |
| Function | is a unique member of the P2Y receptor family because it is activated by both ATP and UTP with similar potency, making it a central sensor of cellular stress and tissue damage. |
| Molecular Weight | 43 kDa |
| Exons | 2 |
| UniProt ID | Q9ULL8 |
| NCBI Gene ID | 5029 |
| Ensembl ID | ENSG00000165326 |
| OMIM | 173415 |
| GeneCards | P2RY2 |
| Human Protein Atlas | P2RY2 |
| Genomic Location | 11q13.2 |
| Associated Diseases | Epilepsy |
| KG Connections | 67 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
P2RY2["<b>P2RY2</b>"]
Inflammation{"Inflammation"}
P2RY2 -->|"activates"| Inflammation
Aging{"Aging"}
P2RY2 -->|"activates"| Aging
Ms{"Ms"}
P2RY2 -->|"activates"| Ms
FOXP3["FOXP3"]
P2RY2 -->|"regulates"| FOXP3
TPH2["TPH2"]
P2RY2 -->|"regulates"| TPH2
CCL3["CCL3"]
P2RY2 -->|"regulates"| CCL3
neurodegeneration["neurodegeneration"]
P2RY2 -->|"implicated in"| neurodegeneration
PANX1["PANX1"]
PANX1 -->|"regulates"| P2RY2
S100B["S100B"]
S100B -->|"regulates"| P2RY2
RELB["RELB"]
RELB -->|"regulates"| P2RY2
P2RY1["P2RY1"]
P2RY1 -->|"regulates"| P2RY2
CASP3["CASP3"]
CASP3 -->|"regulates"| P2RY2
SOCS3["SOCS3"]
SOCS3 -->|"regulates"| P2RY2
TRPA1["TRPA1"]
TRPA1 -->|"regulates"| P2RY2
GENES["GENES"]
GENES -->|"regulates"| P2RY2
CXCL2["CXCL2"]
CXCL2 -->|"regulates"| P2RY2
SNAP25["SNAP25"]
SNAP25 -->|"regulates"| P2RY2
P2RX7["P2RX7"]
P2RX7 -->|"regulates"| P2RY2
SYT2["SYT2"]
SYT2 -->|"regulates"| P2RY2
style P2RY2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Inflammation | activates | disease | 0.65 |
| Aging | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Epilepsy | associated_with | disease | 0.65 |
| FOXP3 | regulates | gene | 0.60 |
| TPH2 | regulates | gene | 0.60 |
| CCL3 | regulates | gene | 0.60 |
| P2RY1 | associated_with | gene | 0.60 |
| MGLUR1 | associated_with | gene | 0.60 |
| CD68 | associated_with | gene | 0.60 |
| epilepsy | regulates | disease | 0.60 |
| epilepsy | associated_with | disease | 0.60 |
| EPILEPSY | associated_with | gene | 0.60 |
| PER | associated_with | gene | 0.60 |
| ASTROCYTES | associated_with | gene | 0.60 |
| SYNAPSE | associated_with | gene | 0.60 |
| Astrocyte | associated_with | cell_type | 0.60 |
| MICROGLIA | associated_with | gene | 0.60 |
| Microglia | associated_with | cell_type | 0.60 |
| Neuron | associated_with | cell_type | 0.60 |
| AND | associated_with | gene | 0.60 |
| NEURON | associated_with | gene | 0.60 |
| astrocytes | expressed_in | cell_type | 0.60 |
| Astrocyte | expressed_in | cell_type | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
| Microglia | expressed_in | cell_type | 0.55 |
| MGLUR1 | regulates | protein | 0.50 |
| MGLUR5 | regulates | protein | 0.50 |
| MGLUR5 | associated_with | protein | 0.50 |
| Astrocyte | regulates | cell_type | 0.50 |
| GLIOSIS | regulates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PANX1 | regulates | gene | 0.60 |
| S100B | regulates | gene | 0.60 |
| RELB | regulates | gene | 0.60 |
| P2RY1 | regulates | gene | 0.60 |
| CASP3 | regulates | gene | 0.60 |
| SOCS3 | regulates | gene | 0.60 |
| TRPA1 | regulates | gene | 0.60 |
| CXCL2 | regulates | gene | 0.60 |
| SNAP25 | regulates | gene | 0.60 |
| P2RX7 | regulates | gene | 0.60 |
| SYT2 | regulates | gene | 0.60 |
| TNF | regulates | gene | 0.60 |
| SOD2 | regulates | gene | 0.60 |
| NOS2 | regulates | gene | 0.60 |
| P2RX3 | regulates | gene | 0.60 |
| RELA | regulates | gene | 0.60 |
| SYP | regulates | gene | 0.60 |
| CHRNA7 | regulates | gene | 0.60 |
| SYT1 | regulates | gene | 0.60 |
| STAT3 | regulates | gene | 0.60 |
| HMOX1 | regulates | gene | 0.60 |
| TRPV1 | regulates | gene | 0.60 |
| P2RY1 | associated_with | gene | 0.60 |
| MGLUR5 | associated_with | gene | 0.60 |
| MGLUR1 | associated_with | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| ANTIOXIDANT GENES | regulates | gene | 0.60 |
| ASTROCYTE | associated_with | gene | 0.60 |
| SYNAPSE | associated_with | gene | 0.60 |
| EPILEPSY | associated_with | gene | 0.60 |
| PER | associated_with | gene | 0.60 |
| ASTROCYTES | associated_with | gene | 0.60 |
| MICROGLIA | associated_with | gene | 0.60 |
| CD68 | co_expressed_with | protein | 0.50 |
| P2RY1 | co_expressed_with | gene | 0.50 |
| EPILEPSY | regulates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||