gene

P2RY2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P2RY2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

67Connections
0Hypotheses
0Analyses
31Outgoing
36Incoming

Summary

P2RY2 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, implicated in. Associated with Aging, Inflammation, Ms. Connected to 31 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolP2RY2
Full NamePurinergic Receptor P2Y2
Chromosome11
Protein FamilyP2Y receptor family (GPCR)
Protein TypeReceptor
Functionis a unique member of the P2Y receptor family because it is activated by both ATP and UTP with similar potency, making it a central sensor of cellular stress and tissue damage.
Molecular Weight43 kDa
Exons2
UniProt IDQ9ULL8
NCBI Gene ID5029
Ensembl IDENSG00000165326
OMIM173415
GeneCardsP2RY2
Human Protein AtlasP2RY2
Genomic Location11q13.2
Associated DiseasesEpilepsy
KG Connections67 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: P2RY2 — AlphaFold Q9ULL8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

P2RY2 (Purinergic Receptor P2Y2)

gene · 2602 words

P2RY1 Gene

gene · 2543 words

P2RY14 Gene - Purinergic Receptor P2Y14

gene · 1217 words

P2RX3 Gene

gene · 927 words

P2Y2 Neurons

cell · 742 words

mGluR1 Protein

protein · 728 words

Pathway Diagram

graph TD
    P2RY2["<b>P2RY2</b>"]
    Inflammation{"Inflammation"}
    P2RY2 -->|"activates"| Inflammation
    Aging{"Aging"}
    P2RY2 -->|"activates"| Aging
    Ms{"Ms"}
    P2RY2 -->|"activates"| Ms
    FOXP3["FOXP3"]
    P2RY2 -->|"regulates"| FOXP3
    TPH2["TPH2"]
    P2RY2 -->|"regulates"| TPH2
    CCL3["CCL3"]
    P2RY2 -->|"regulates"| CCL3
    neurodegeneration["neurodegeneration"]
    P2RY2 -->|"implicated in"| neurodegeneration
    PANX1["PANX1"]
    PANX1 -->|"regulates"| P2RY2
    S100B["S100B"]
    S100B -->|"regulates"| P2RY2
    RELB["RELB"]
    RELB -->|"regulates"| P2RY2
    P2RY1["P2RY1"]
    P2RY1 -->|"regulates"| P2RY2
    CASP3["CASP3"]
    CASP3 -->|"regulates"| P2RY2
    SOCS3["SOCS3"]
    SOCS3 -->|"regulates"| P2RY2
    TRPA1["TRPA1"]
    TRPA1 -->|"regulates"| P2RY2
    GENES["GENES"]
    GENES -->|"regulates"| P2RY2
    CXCL2["CXCL2"]
    CXCL2 -->|"regulates"| P2RY2
    SNAP25["SNAP25"]
    SNAP25 -->|"regulates"| P2RY2
    P2RX7["P2RX7"]
    P2RX7 -->|"regulates"| P2RY2
    SYT2["SYT2"]
    SYT2 -->|"regulates"| P2RY2
    style P2RY2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (31)

TargetRelationTypeStr
Inflammationactivatesdisease0.65
Agingactivatesdisease0.65
Msactivatesdisease0.65
Epilepsyassociated_withdisease0.65
FOXP3regulatesgene0.60

Incoming (36)

SourceRelationTypeStr
PANX1regulatesgene0.60
S100Bregulatesgene0.60
RELBregulatesgene0.60
P2RY1regulatesgene0.60
CASP3regulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found