cell_type

Monocyte

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Monocyte: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

528Connections

1Hypotheses

2Analyses

4Outgoing

50Incoming

No summary available yet. View on Wiki →

🧫 Cell Type Info

Cell Type	Monocyte
Key Markers	TNF-α, TMEM119, GAIN, FCRLS, TREM2, P2RY12, MICROGLIA, KCNK2
Key Pathways	Oxidative Phosphorylation, Wnt, Lipid Metabolism, Immune Response, Blood-Brain Barrier
Associated Diseases	Neuroinflammation, Cancer, Aging, Neurodegeneration, Stroke, Hypertension
Linked Hypotheses	79 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Monocyte["Monocyte"] -->|"expressed in"| Spinal_Cord["Spinal Cord"]
    style Spinal_Cord fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Monocyte["Monocyte"] -->|"expressed in"| Brainstem["Brainstem"]
    style Brainstem fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Monocyte["Monocyte"] -->|"expressed in"| Hippocampus["Hippocampus"]
    style Hippocampus fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Monocyte["Monocyte"] -->|"expressed in"| Cortex["Cortex"]
    style Cortex fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    TMEM119["TMEM119"] -->|"biomarker for"| Monocyte["Monocyte"]
    style TMEM119 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    GAIN["GAIN"] -->|"biomarker for"| Monocyte["Monocyte"]
    style GAIN fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    FCRLS["FCRLS"] -->|"biomarker for"| Monocyte["Monocyte"]
    style FCRLS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    TREM2["TREM2"] -->|"biomarker for"| Monocyte["Monocyte"]
    style TREM2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    P2RY12["P2RY12"] -->|"biomarker for"| Monocyte["Monocyte"]
    style P2RY12 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style Monocyte fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (44)

Target	Relation	Type	Str
Spinal Cord	expressed_in	brain_region	0.50
Brainstem	expressed_in	brain_region	0.50
Hippocampus	expressed_in	brain_region	0.50
Cortex	expressed_in	brain_region	0.50

Incoming (484)

Source	Relation	Type	Str
TMEM119	biomarker_for	gene	0.60
GAIN	biomarker_for	gene	0.60
FCRLS	biomarker_for	gene	0.60
TREM2	biomarker_for	gene	0.60
P2RY12	biomarker_for	gene	0.60
MICROGLIA	associated_with	gene	0.60
KCNK2	associated_with	gene	0.60
WNT	associated_with	gene	0.60
RNA	expressed_in	gene	0.60
SCN1A	associated_with	gene	0.60
KCNQ1	associated_with	gene	0.60
TRPA1	associated_with	gene	0.60
SCN5A	associated_with	gene	0.60
PIEZO1	expressed_in	gene	0.60
CACNA1B	associated_with	gene	0.60
TRPV1	associated_with	gene	0.60
PIEZO2	associated_with	gene	0.60
KCNN4	associated_with	gene	0.60
HIPPO	associated_with	gene	0.60
SCNN1A	associated_with	gene	0.60
CFTR	associated_with	gene	0.60
AXON	associated_with	gene	0.60
TRPM7	associated_with	gene	0.60
TRPV4	expressed_in	gene	0.60
CACNA1C	expressed_in	gene	0.60
KCNMA1	associated_with	gene	0.60
REELIN	associated_with	gene	0.60
LRP8	associated_with	gene	0.60
APOER2	associated_with	gene	0.60
PAH	activates	gene	0.60
LRP4	associated_with	gene	0.60
STROKE	associated_with	gene	0.60
LRP1B	associated_with	gene	0.60
LDLR	associated_with	gene	0.60
LRP2	associated_with	gene	0.60
LRP1	associated_with	gene	0.60
LDL	associated_with	gene	0.60
AGING	associated_with	gene	0.60
NAD	inhibits	gene	0.60
NAMPT	inhibits	gene	0.60
CD38	inhibits	gene	0.60
SIRT6	inhibits	gene	0.60
PARP1	inhibits	gene	0.60
EGR2	activates	gene	0.60
IL-10	activates	gene	0.60
MMP2	biomarker_for	gene	0.60
MMP9	biomarker_for	gene	0.60
CD14	associated_with	gene	0.60
CD163	associated_with	gene	0.60
CD68	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2 Agonism to Reprogram Infiltrated Monocytes Toward Neur	0.584	neurodegeneration	What are the specific molecular mechanis

Mentioning Analyses (2)

Scientific analyses that reference this entity

What are the specific molecular mechanisms by which peripheral monocytes cross t

neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.584

Systemic immune profiling and peripheral immune contributions to neurodegenerati

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Monocyte

Understanding Entity Pages

Wiki Pages (20)

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Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

neuroinflammation

Microglial Cells — Cell Type Hierarchy

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

Astrocyte Reactivity Mechanism

CLCN10 — Chloride Voltage-Gated Channel 10

Blood-Brain Barrier Dysfunction in Neurodegeneration

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

Blood-Brain Barrier Biology and Crossing Strategies

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NPAS3 Gene

Ion Channel Dysfunction in Huntington's Disease

Transcriptional Regulation in Neurodegeneration

Psychobiotic Therapy for Neurodegenerative Diseases

Neuroinflammation Across AD, PD, ALS, FTD, and HD

Meningeal Lymphatics