gene

RIPK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RIPK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

326Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

RIPK2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, interacts with. Associated with Als, Alzheimer, Amyotrophic Lateral Sclerosis. Connected to 123 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RIPK2
Full Name	Receptor-Interacting Serine/Threonine Kinase 2
Chromosome	8q21.3
Protein Type	Serine/Threonine Kinase
Function	is a critical serine/threonine kinase that serves as the primary signaling adaptor for NOD1 and NOD2 pattern recognition receptors.
Molecular Weight	61 kDa
Amino Acids	540 aa
Pathways	NF-κB, MAPK, MAPK signaling
UniProt ID	Q9Y2K6
NCBI Gene ID	8767
Ensembl ID	ENSG00000137275
OMIM	603614
GeneCards	RIPK2
Human Protein Atlas	RIPK2
Alternative Names	RIP2, CARDIAK, RICK, RIPK2
Associated Diseases	Alzheimer, Amyotrophic Lateral Sclerosis, Cancer, Colorectal Cancer, IBD, Inflammatory Bowel Disease
Known Drugs/Compounds	rapamycin
Interactions	IFIH1, GNAI1, ATG16L1, GNG2, GNAI2, NOD2
KG Connections	326 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RIPK2 — AlphaFold Q9Y2K6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (17)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RIPK2["RIPK2"]
    RIPK2 -->|"target for"| Carcinoma["Carcinoma"]
    RIPK2 -->|"target for"| Cancer["Cancer"]
    RIPK2 -->|"regulates"| Tumor["Tumor"]
    RIPK2 -->|"target for"| Inflammation["Inflammation"]
    RIPK2 -->|"target for"| Alzheimer["Alzheimer"]
    RIPK2 -->|"target for"| Traumatic_Brain_Injury["Traumatic Brain Injury"]
    RIPK2 -->|"target for"| Stroke["Stroke"]
    RIPK2 -->|"target for"| Multiple_Sclerosis["Multiple Sclerosis"]
    RIPK2 -->|"target for"| Als["Als"]
    RIPK2 -->|"target for"| Neuroinflammation["Neuroinflammation"]
    MITOPHAGY["MITOPHAGY"] -->|"activates"| RIPK2
    NBR1["NBR1"] -->|"regulates"| RIPK2
    MHC_I["MHC-I"] -->|"regulates"| RIPK2
    CANCER["CANCER"] -->|"target for"| RIPK2
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"target for"| RIPK2
    NF_KB["NF-KB"] -->|"activates"| RIPK2
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"target for"| RIPK2
    CYTOKINES["CYTOKINES"] -->|"activates"| RIPK2
    XIAP["XIAP"] -->|"activates"| RIPK2
    INFLAMMATION["INFLAMMATION"] -->|"target for"| RIPK2

Outgoing (215)

Target	Relation	Type	Str
Nf-Kb Pathway	activates	pathway	0.90
Mapk Pathway	activates	pathway	0.90
NF-KB Pathway	activates	pathway	0.85
MAPK Pathway	activates	pathway	0.85
neurological inflammation	targets	disease	0.80
Neuroinflammation	targets	process	0.80
Neuroinflammation	involved_in	process	0.80
ULK1	associated_with	gene	0.70
NLRP3	associated_with	gene	0.70
STAT3	activates	entity	0.70
IBD	associated_with	disease	0.70
MAP1LC3	associated_with	gene	0.70
Autophagy	associated_with	pathway	0.70
necroptosis	participates_in	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
Carcinoma	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	regulates	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Traumatic Brain Injury	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
Multiple Sclerosis	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Cardiovascular	expressed_in	disease	0.65
Colorectal Cancer	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Inflammatory Bowel Disease	associated_with	disease	0.65
Infection	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Traumatic Brain Injury	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
NR4A1	associated_with	gene	0.60
PINK1	associated_with	gene	0.60
TUFM	associated_with	gene	0.60
TRAF2	associated_with	gene	0.60
DNM1L	associated_with	gene	0.60
RIPK1	therapeutic_target	gene	0.60
RIPK3	therapeutic_target	gene	0.60
IFIH1	interacts_with	gene	0.60

Incoming (111)

Source	Relation	Type	Str
NOD1	interacts_with	protein	0.85
NOD2	interacts_with	protein	0.85
NOD1	activates	protein	0.85
UBIQUITIN	binds_to	entity	0.80
NOD1	recruits	gene	0.80
NOD2	recruits	gene	0.80
XIAP	ubiquitinates	gene	0.80
LUBAC	modifies	protein	0.80
BCL2	associated_with	gene	0.60
FUNDC1	associated_with	gene	0.60
PARKIN	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
TNF	associated_with	gene	0.60
FIS1	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
LC3	associated_with	gene	0.60
BCL2L13	associated_with	gene	0.60
MFF	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
SESN2	associated_with	gene	0.60
STX17	associated_with	gene	0.60
MAVS	associated_with	gene	0.60
IKBKE	associated_with	gene	0.60
OPA1	associated_with	gene	0.60
BNIP3L	associated_with	gene	0.60
PTEN	associated_with	gene	0.60
NBR1	regulates	gene	0.60
XIAP	activates	gene	0.60
NOD2	activates	gene	0.60
AKT1	interacts_with	gene	0.60
AKT	interacts_with	gene	0.60
GNB1	interacts_with	gene	0.60
AMPD2	expressed_in	gene	0.60
ATG5	interacts_with	gene	0.60
MAVS	interacts_with	gene	0.60
TBK1	interacts_with	gene	0.60
CLCN7	expressed_in	gene	0.60
NLRP3	associated_with	gene	0.60
NR4A1	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
RIPK1	therapeutic_target	entity	0.60
ASC	activates	gene	0.60
BRG1	activates	gene	0.60
LC3	activates	gene	0.60
MTOR	activates	gene	0.60
NLRP3	activates	gene	0.60
PI3K	activates	gene	0.60
IRGM1	activates	gene	0.60
CLDN2	activates	gene	0.60
RALGAPA2	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

RIPK2

Understanding Entity Pages

Summary

Wiki Pages (17)

RIPK2 (Receptor-Interacting Serine/Threonine-Protein Kinase 2)

nlrc5-protein

Necroptotic Neurons

UBE2V1 Gene (UEV-1)

PRKCI

RIPK1 Inhibitor Therapy

CASP1 Gene

AMPD2 — Adenosine Monophosphate Deaminase 2

RIPK1 Inhibitor Therapy

RIPK1 Inhibitors in Neurodegeneration

RIPK2 Protein

MAPK7

GNB1 Gene - G Protein Subunit Beta 1

IKBKE (IKKε)

NOD2 Gene