Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NFH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NFH is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, associated with, therapeutic target. Associated with Ms. Connected to 15 entities in the SciDEX knowledge graph.
| Gene Symbol | NFH |
| Chromosome | 22q12.2 |
| Function | is a neuronal intermediate filament protein encoded by the NEFH gene on chromosome 22q12. |
| Molecular Weight | 200 kDa |
| Amino Acids | 816 aa |
| Exons | 4 |
| GeneCards | NFH |
| Human Protein Atlas | NFH |
| Category | Axonal Injury Biomarker |
| Target | NfH protein in CSF/blood |
| Sample Type | CSF, Plasma, Serum |
| Clinical Utility | Disease progression, treatment response |
| Associated Diseases | neurodegeneration |
| KG Connections | 14 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NFH["<b>NFH</b>"]
Ms{"Ms"}
NFH -->|"therapeutic target"| Ms
TNFRSF1A["TNFRSF1A"]
NFH -->|"biomarker for"| TNFRSF1A
IKBKB["IKBKB"]
NFH -->|"associated with"| IKBKB
Akt(["Akt"])
NFH -->|"biomarker for"| Akt
neurodegeneration["neurodegeneration"]
NFH -->|"implicated in"| neurodegeneration
BCL2L1["BCL2L1"]
BCL2L1 -->|"biomarker for"| NFH
CASP1["CASP1"]
CASP1 -->|"associated with"| NFH
NFKBIA["NFKBIA"]
NFKBIA -->|"associated with"| NFH
CASP8["CASP8"]
CASP8 -->|"biomarker for"| NFH
IL1B["IL1B"]
IL1B -->|"associated with"| NFH
XIAP["XIAP"]
XIAP -->|"biomarker for"| NFH
AKT1["AKT1"]
AKT1 -->|"biomarker for"| NFH
STAT3["STAT3"]
STAT3 -->|"biomarker for"| NFH
CFLAR["CFLAR"]
CFLAR -->|"associated with"| NFH
RIPK1["RIPK1"]
RIPK1 -->|"associated with"| NFH
style NFH fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Source | Relation | Type | Str |
|---|---|---|---|
| BCL2L1 | biomarker_for | gene | 0.60 |
| CASP1 | associated_with | gene | 0.60 |
| NFKBIA | associated_with | gene | 0.60 |
| CASP8 | biomarker_for | gene | 0.60 |
| IL1B | associated_with | gene | 0.60 |
| XIAP | biomarker_for | gene | 0.60 |
| AKT1 | biomarker_for | gene | 0.60 |
| STAT3 | biomarker_for | gene | 0.60 |
| CFLAR | associated_with | gene | 0.60 |
| RIPK1 | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||