gene

NFH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NFH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections
0Hypotheses
0Analyses
4Outgoing
10Incoming

Summary

NFH is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, associated with, therapeutic target. Associated with Ms. Connected to 15 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolNFH
Chromosome22q12.2
Functionis a neuronal intermediate filament protein encoded by the NEFH gene on chromosome 22q12.
Molecular Weight200 kDa
Amino Acids816 aa
Exons4
GeneCardsNFH
Human Protein AtlasNFH
CategoryAxonal Injury Biomarker
TargetNfH protein in CSF/blood
Sample TypeCSF, Plasma, Serum
Clinical UtilityDisease progression, treatment response
Associated Diseasesneurodegeneration
KG Connections14 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Neurofilament Heavy Chain (NfH)

biomarker · 1103 words

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

therapeutic · 5600 words

HNRNPA2B1 Protein

protein · 5015 words

Axonal Transport Dysfunction Comparison Across Neurodegenerative Diseases

mechanism · 4604 words

DIAN-TU-001 Trial (NCT01760005)

clinical · 4560 words

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

clinical · 4511 words

Pathway Diagram

graph TD
    NFH["<b>NFH</b>"]
    Ms{"Ms"}
    NFH -->|"therapeutic target"| Ms
    TNFRSF1A["TNFRSF1A"]
    NFH -->|"biomarker for"| TNFRSF1A
    IKBKB["IKBKB"]
    NFH -->|"associated with"| IKBKB
    Akt(["Akt"])
    NFH -->|"biomarker for"| Akt
    neurodegeneration["neurodegeneration"]
    NFH -->|"implicated in"| neurodegeneration
    BCL2L1["BCL2L1"]
    BCL2L1 -->|"biomarker for"| NFH
    CASP1["CASP1"]
    CASP1 -->|"associated with"| NFH
    NFKBIA["NFKBIA"]
    NFKBIA -->|"associated with"| NFH
    CASP8["CASP8"]
    CASP8 -->|"biomarker for"| NFH
    IL1B["IL1B"]
    IL1B -->|"associated with"| NFH
    XIAP["XIAP"]
    XIAP -->|"biomarker for"| NFH
    AKT1["AKT1"]
    AKT1 -->|"biomarker for"| NFH
    STAT3["STAT3"]
    STAT3 -->|"biomarker for"| NFH
    CFLAR["CFLAR"]
    CFLAR -->|"associated with"| NFH
    RIPK1["RIPK1"]
    RIPK1 -->|"associated with"| NFH
    style NFH fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (4)

TargetRelationTypeStr
Mstherapeutic_targetdisease0.65
TNFRSF1Abiomarker_forgene0.60
IKBKBassociated_withgene0.60
Aktbiomarker_forpathway0.60

Incoming (10)

SourceRelationTypeStr
BCL2L1biomarker_forgene0.60
CASP1associated_withgene0.60
NFKBIAassociated_withgene0.60
CASP8biomarker_forgene0.60
IL1Bassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found