gene

XIAP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about XIAP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

162Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

XIAP is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, therapeutic target. Associated with Als, Alzheimer, Amyotrophic Lateral Sclerosis. Connected to 111 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	XIAP
Full Name	X-Linked Inhibitor of Apoptosis
Chromosome	Xq25
Function	XIAP (X-linked Inhibitor of Apoptosis) is the best-characterized member of the Inhibitor of Apoptosis (IAP) protein family.
Primary Expression	neuronal tissues where it protects against apoptosis induced by various stimuli including oxidative stress, mitochondrial dysfu
Pathways	NF-κB
UniProt ID	[P98170](https://www.uniprot.org/uniprot/P98170)
Ensembl ID	ENSG00000101966
GeneCards	XIAP
Human Protein Atlas	XIAP
Associated Diseases	Cancer, Ms
Interactions	NOD2, RIPK2, RIPK1, RIPK3, PTEN, BCL2
KG Connections	162 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    XIAP["<b>XIAP</b>"]
    Inflammation{"Inflammation"}
    XIAP -->|"activates"| Inflammation
    Alzheimer{"Alzheimer"}
    XIAP -->|"activates"| Alzheimer
    Traumatic_Brain_Injury{"Traumatic Brain Injury"}
    XIAP -->|"activates"| Traumatic_Brain_Injury
    Stroke{"Stroke"}
    XIAP -->|"activates"| Stroke
    Multiple_Sclerosis{"Multiple Sclerosis"}
    XIAP -->|"activates"| Multiple_Sclerosis
    Als{"Als"}
    XIAP -->|"activates"| Als
    Neuroinflammation{"Neuroinflammation"}
    XIAP -->|"activates"| Neuroinflammation
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    XIAP -->|"activates"| Amyotrophic_Lateral_Sclerosis
    Parkinson{"Parkinson"}
    XIAP -->|"activates"| Parkinson
    Ms{"Ms"}
    XIAP -->|"activates"| Ms
    XIAP -->|"associated with"| Ms
    INFLAMMATION["INFLAMMATION"]
    XIAP -->|"activates"| INFLAMMATION
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"activates"| XIAP
    NF_KB["NF-KB"]
    NF_KB -->|"activates"| XIAP
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"activates"| XIAP
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"activates"| XIAP
    BCL2L1["BCL2L1"]
    BCL2L1 -->|"biomarker for"| XIAP
    CASP1["CASP1"]
    CASP1 -->|"associated with"| XIAP
    NFKBIA["NFKBIA"]
    NFKBIA -->|"associated with"| XIAP
    CASP8["CASP8"]
    CASP8 -->|"biomarker for"| XIAP
    IL1B["IL1B"]
    IL1B -->|"associated with"| XIAP
    style XIAP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (100)

Target	Relation	Type	Str
Apoptosis	inhibits	pathway	0.90
ULK1	phosphorylates	protein	0.85
RIPK2	ubiquitinates	gene	0.80
Cancer	therapeutic_target	disease	0.75
Apoptosis	activates	pathway	0.70
APOPTOSIS	inhibits	gene	0.70
CANCER	therapeutic_target	gene	0.70
Inflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Stroke	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Als	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Parkinson	activates	disease	0.65
Ms	activates	disease	0.65
Ms	associated_with	disease	0.65
Insulin Resistance	inhibits	disease	0.65
Fatty Liver	inhibits	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Autoimmune	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Cancer	inhibits	disease	0.65
Leukemia	inhibits	disease	0.65
Diabetes	regulates	disease	0.65
Traumatic Brain Injury	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Tumor	activates	disease	0.65
Breast Cancer	activates	disease	0.65
Cancer	activates	disease	0.65
NOD2	activates	gene	0.60
RIPK2	activates	gene	0.60
RIPK1	activates	gene	0.60
RIPK3	activates	gene	0.60
AKT1	biomarker_for	gene	0.60
STAT3	biomarker_for	gene	0.60
CFLAR	associated_with	gene	0.60
RIPK1	associated_with	gene	0.60
NFH	biomarker_for	gene	0.60
TNFRSF1A	biomarker_for	gene	0.60
IKBKB	associated_with	gene	0.60
PTEN	inhibits	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
TRAF6	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
BCL2	inhibits	gene	0.60
RBM10	inhibits	gene	0.60

Incoming (62)

Source	Relation	Type	Str
APOPTOSIS	inhibits	gene	0.70
BCL2L1	biomarker_for	gene	0.60
CASP1	associated_with	gene	0.60
NFKBIA	associated_with	gene	0.60
CASP8	biomarker_for	gene	0.60
IL1B	associated_with	gene	0.60
AKT	inhibits	gene	0.60
PTEN	therapeutic_target	gene	0.60
IRAK1	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
MAPK1	therapeutic_target	gene	0.60
BCL2A1	inhibits	gene	0.60
PTEN	activates	gene	0.60
PI3K	activates	gene	0.60
FASN	activates	gene	0.60
ULK1	regulates	gene	0.60
NOD2	activates	entity	0.60
RIPK2	activates	entity	0.60
RIPK1	activates	gene	0.60
RIPK3	activates	gene	0.60
ERK1	expressed_in	gene	0.60
SRC	expressed_in	gene	0.60
ERK1	inhibits	gene	0.60
SRC	inhibits	gene	0.60
EGF	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
NF-KB	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
CYTOKINES	activates	gene	0.60
MIRNAS	inhibits	gene	0.60
KRAS	therapeutic_target	gene	0.60
NF-ΚB	therapeutic_target	gene	0.60
AUTOPHAGY	regulates	gene	0.60
APOPTOSIS	activates	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
P53	activates	gene	0.60
TRIM21	activates	gene	0.60
CANCER	activates	gene	0.60
AND	inhibits	gene	0.60
INSULIN RESISTANCE	inhibits	gene	0.60
AND	regulates	gene	0.60
MITOPHAGY	regulates	gene	0.60
INFLAMMATION	activates	gene	0.60
ALS	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
STROKE	activates	gene	0.60
MAPK	activates	gene	0.60
AND	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

XIAP

Understanding Entity Pages

Summary

Wiki Pages (21)

XIAP

Excitotoxicity Pathway

Cytochrome c Protein

AIFM1 Gene

OTULIN-Tau Regulation Pathway

Apoptosis Pathway in Neurodegeneration

Stress Granule Dysfunction Hypothesis in Parkinson's Disease

NF-κB Signaling in Neurodegeneration

Hedgehog Signaling in Neurodegeneration

CYLD Protein — Lysine-Specific Deubiquitinase in Neurodegeneration

Caspase-3 Protein

Mitochondrially Impaired Neurons

YAP/TAZ Signaling Pathway in Neurodegeneration

BIRC5 (Survivin)

NF-κB Pathway Inhibition for Neurodegeneration

CASP9 (Caspase 9)

coq10-qe3

CASP12 Gene — Cysteine-Containing Aspartate-Specific Protease 12

Wnt Signaling Modulators for Neurodegeneration

CRYAB Gene

casp3

Pathway Diagram

Outgoing (100)

Incoming (62)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)