gene

TNFRSF1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNFRSF1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

154Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

TNFRSF1A (TNFR1) - TNF receptor in neuroinflammation and neurodegeneration

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🧬 Gene Info

Gene Symbol	TNFRSF1A
Full Name	Tumor necrosis factor receptor superfamily member 1A
Aliases	TNFR1
Chromosome	12p13.31
Function	TNFRSF1A encodes TNFR1, a receptor that plays central roles in inflammation and cell survival:
Molecular Weight	55 kDa
Amino Acids	455 aa
Exons	10
Pathways	NF-κB Signaling, NF-κB, MAPK Pathway, MAPK
UniProt ID	P19438
NCBI Gene ID	7132
Ensembl ID	ENSG00000082258
OMIM	191190
GeneCards	TNFRSF1A
Human Protein Atlas	TNFRSF1A
Associated Diseases	Atherosclerosis, Diabetes, Ms
Interactions	OCLN, ICAM1, BMAL1, ARNT, TNF, CRY1
KG Connections	154 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TNFRSF1A — AlphaFold P19438 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TNFRSF1A["TNFRSF1A"]
    TNFRSF1A -->|"activates"| Inflammation["Inflammation"]
    TNFRSF1A -->|"activates"| Anxiety["Anxiety"]
    TNFRSF1A -->|"activates"| Als["Als"]
    TNFRSF1A -->|"activates"| Tumor["Tumor"]
    TNFRSF1A -->|"activates"| Depression["Depression"]
    TNFRSF1A -->|"activates"| Ms["Ms"]
    CRY1["CRY1"] -->|"activates"| TNFRSF1A
    BMAL1["BMAL1"] -->|"activates"| TNFRSF1A
    ARNT["ARNT"] -->|"activates"| TNFRSF1A
    TNF["TNF"] -->|"activates"| TNFRSF1A
    OCLN["OCLN"] -->|"activates"| TNFRSF1A
    ICAM1["ICAM1"] -->|"activates"| TNFRSF1A

Outgoing (98)

Target	Relation	Type	Str
Inflammation	activates	disease	0.65
Anxiety	activates	disease	0.65
Als	activates	disease	0.65
Tumor	activates	disease	0.65
Depression	activates	disease	0.65
Ms	activates	disease	0.65
Anxiety	contributes_to	disease	0.65
Depression	contributes_to	disease	0.65
Inflammation	contributes_to	disease	0.65
Tumor	contributes_to	disease	0.65
Diabetes	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Heart Failure	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
ALS	activates	disease	0.65
Inflammation	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Cancer	activates	disease	0.65
Tumor	regulates	disease	0.65
ALS	regulates	disease	0.65
OCLN	activates	gene	0.60
ICAM1	activates	gene	0.60
BMAL1	activates	gene	0.60
ARNT	activates	gene	0.60
CX3CR1	regulates	gene	0.60
CXCR4	expressed_in	gene	0.60
IKBKB	associated_with	gene	0.60
TNF	activates	gene	0.60
CRY1	activates	gene	0.60
IBA1	activates	gene	0.60
STAT3	regulates	gene	0.60
NFKBIA	regulates	gene	0.60
CSF1	regulates	gene	0.60
IL6ST	regulates	gene	0.60
FGFR1	regulates	gene	0.60
NFKB2	regulates	gene	0.60
NOTCH2	regulates	gene	0.60
FYCO1	interacts_with	gene	0.60
DR5	activates	gene	0.60
TRAIL	activates	gene	0.60
CASP8	activates	gene	0.60
TNF	interacts_with	gene	0.60
TNFR1	interacts_with	gene	0.60
GAIN	regulates	gene	0.60
Rb	activates	protein	0.60
neuroinflammation	activates	disease	0.60
Circadian Rhythm	activates	pathway	0.60

Incoming (56)

Source	Relation	Type	Str
PHF2	regulates	enzyme	0.95
IBA1	activates	entity	0.60
CRY1	activates	gene	0.60
BMAL1	activates	gene	0.60
ARNT	activates	gene	0.60
TNF	activates	gene	0.60
OCLN	activates	gene	0.60
ARNT	contributes_to	gene	0.60
BMAL1	contributes_to	gene	0.60
CRY1	contributes_to	gene	0.60
ICAM1	activates	gene	0.60
OCLN	contributes_to	gene	0.60
VEGF	associated_with	gene	0.60
JUNB	regulates	gene	0.60
TNF	regulates	gene	0.60
TFRC	associated_with	gene	0.60
CD44	expressed_in	gene	0.60
CASP1	expressed_in	gene	0.60
MYD88	expressed_in	gene	0.60
TPM3	expressed_in	gene	0.60
RIPK1	expressed_in	gene	0.60
BCL2L1	biomarker_for	gene	0.60
CASP1	associated_with	gene	0.60
NFKBIA	associated_with	gene	0.60
CASP8	biomarker_for	gene	0.60
IL1B	associated_with	gene	0.60
XIAP	biomarker_for	gene	0.60
AKT1	biomarker_for	gene	0.60
STAT3	biomarker_for	gene	0.60
CFLAR	associated_with	gene	0.60
RIPK1	associated_with	gene	0.60
NFH	biomarker_for	gene	0.60
RAB7A	activates	gene	0.60
TNFSF10	activates	gene	0.60
TNF	interacts_with	gene	0.60
GAIN	regulates	gene	0.60
TNFR1	interacts_with	gene	0.60
IL1	associated_with	gene	0.60
IL6R	associated_with	gene	0.60
DIABETES MELLITUS	associated_with	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
IMMUNE INFILTRATION	expressed_in	gene	0.60
MICROGLIA	activates	gene	0.60
ANXIETY	activates	gene	0.60
GENES	activates	gene	0.60
MICROGLIA ACTIVATION	activates	gene	0.60
TNF-Α	activates	gene	0.60
DEPRESSION	activates	gene	0.60
CYTOKINES	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TNFRSF1A

Understanding Entity Pages

Summary

Wiki Pages (21)

TNFRSF1A Gene

Tumor Necrosis Factor Alpha (TNF-α) as a Neurodegenerative Disease Biomarker

TNF Signaling Pathway in Neurodegeneration

p75NTR Protein

AGER/RAGE Protein

TNF Gene

TNFRSF1A Gene

FADD Gene

TNFRSF1B Gene

TRADD Gene

TAB3 Gene

Neurofilament Heavy Chain (NfH)

TNF Alpha Protein

Oligodendrocyte Precursor Cells in Periventricular Leukomalacia

TNFRSF1B Gene

BAG4

TNFR2 (TNFRSF1B Protein)

TNF-alpha Protein - Tumor Necrosis Factor

TNFR1 Protein