gene

TNFRSF1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNFRSF1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

159Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

TNFRSF1A (TNFR1) - TNF receptor in neuroinflammation and neurodegeneration

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🧬 Gene Info

Gene Symbol	TNFRSF1A
Full Name	Tumor necrosis factor receptor superfamily member 1A
Aliases	TNFR1
Chromosome	12p13.31
Function	TNFRSF1A encodes TNFR1, a receptor that plays central roles in inflammation and cell survival:
Molecular Weight	55 kDa
Amino Acids	455 aa
Exons	10
Pathways	NF-κB Signaling, NF-κB, MAPK Pathway, MAPK
UniProt ID	P19438
NCBI Gene ID	7132
Ensembl ID	ENSG00000082258
OMIM	191190
GeneCards	TNFRSF1A
Human Protein Atlas	TNFRSF1A
Associated Diseases	Atherosclerosis, Diabetes, Microglial priming, Ms
Interactions	ANXIETY, APOPTOSIS, App, ARNT, BMAL1, CANCER
KG Connections	159 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TNFRSF1A — AlphaFold P19438 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TNFRSF1A Gene

gene · 611 words

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TNFRSF1A Gene

gene · 2121 words

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Pathway Diagram

graph TD
    TNFRSF1A["TNFRSF1A"]
    TNFRSF1A -->|"activates"| Inflammation["Inflammation"]
    TNFRSF1A -->|"activates"| Anxiety["Anxiety"]
    TNFRSF1A -->|"activates"| Als["Als"]
    TNFRSF1A -->|"activates"| Tumor["Tumor"]
    TNFRSF1A -->|"activates"| Depression["Depression"]
    TNFRSF1A -->|"activates"| Ms["Ms"]
    CRY1["CRY1"] -->|"activates"| TNFRSF1A
    BMAL1["BMAL1"] -->|"activates"| TNFRSF1A
    ARNT["ARNT"] -->|"activates"| TNFRSF1A
    TNF["TNF"] -->|"activates"| TNFRSF1A
    OCLN["OCLN"] -->|"activates"| TNFRSF1A
    ICAM1["ICAM1"] -->|"activates"| TNFRSF1A

Outgoing (102)

Target	Relation	Type	Str
C1R expression	activates	process	0.70
positive_feedback_loops	modulates	mechanism	0.70
Microglial priming	mediates	phenotype	0.70
Microglial priming	causes	phenotype	0.70
C1S expression	activates	process	0.70
microglial_priming	regulates	phenotype	0.70
Neuroinflammation	regulates	disease	0.65
Anxiety	contributes_to	disease	0.65
Depression	activates	disease	0.65
Heart Failure	expressed_in	disease	0.65
Tumor	contributes_to	disease	0.65
Inflammation	contributes_to	disease	0.65
Anxiety	activates	disease	0.65
Tumor	activates	disease	0.65
Ms	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
ALS	regulates	disease	0.65
Depression	contributes_to	disease	0.65
Cancer	activates	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Ms	expressed_in	disease	0.65
ALS	activates	disease	0.65
Tumor	regulates	disease	0.65
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
Inflammation	regulates	disease	0.65
Als	activates	disease	0.65
Alzheimer	regulates	disease	0.65
FGFR1	regulates	gene	0.60
IL6ST	regulates	gene	0.60
IKBKB	associated_with	gene	0.60
neuroinflammation	activates	disease	0.60
CSF1	regulates	gene	0.60
Rb	activates	protein	0.60
GAIN	regulates	gene	0.60
NFKBIA	regulates	gene	0.60
CXCR4	expressed_in	gene	0.60
BMAL1	activates	gene	0.60
TNFR1	interacts_with	gene	0.60
Mapk	associated_with	pathway	0.60
TNF	interacts_with	gene	0.60
STAT3	regulates	gene	0.60
Autophagy	associated_with	pathway	0.60
CASP8	activates	gene	0.60
Necroptosis	regulates	pathway	0.60
Akt	biomarker_for	pathway	0.60
TNF-Α	activates	gene	0.60
ANXIETY	activates	gene	0.60
TRAIL	activates	gene	0.60

Incoming (57)

Source	Relation	Type	Str
PHF2	regulates	enzyme	0.95
IL1R1	associated_with	gene	0.70
OCLN	activates	gene	0.60
APOPTOSIS	regulates	gene	0.60
CD44	expressed_in	gene	0.60
CASP1	expressed_in	gene	0.60
MYD88	expressed_in	gene	0.60
TPM3	expressed_in	gene	0.60
RIPK1	expressed_in	gene	0.60
BCL2L1	biomarker_for	gene	0.60
CASP1	associated_with	gene	0.60
NFKBIA	associated_with	gene	0.60
CASP8	biomarker_for	gene	0.60
IL1B	associated_with	gene	0.60
XIAP	biomarker_for	gene	0.60
AKT1	biomarker_for	gene	0.60
STAT3	biomarker_for	gene	0.60
CFLAR	associated_with	gene	0.60
RIPK1	associated_with	gene	0.60
NFH	biomarker_for	gene	0.60
RAB7A	activates	gene	0.60
TNFSF10	activates	gene	0.60
IBA1	activates	entity	0.60
IL1	associated_with	gene	0.60
IL6R	associated_with	gene	0.60
INFLAMMATION	activates	gene	0.60
INFLAMMATION	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
VEGF	associated_with	gene	0.60
JUNB	regulates	gene	0.60
TNF	regulates	gene	0.60
TFRC	associated_with	gene	0.60
TNFR1	interacts_with	gene	0.60
MICROGLIA	activates	gene	0.60
ANXIETY	activates	gene	0.60
GENES	activates	gene	0.60
MICROGLIA ACTIVATION	activates	gene	0.60
TNF-Α	activates	gene	0.60
DEPRESSION	activates	gene	0.60
CYTOKINES	activates	gene	0.60
RUBCNL	interacts_with	gene	0.60
BMAL1	activates	gene	0.60
ARNT	activates	gene	0.60
TNF	activates	gene	0.60
ARNT	contributes_to	gene	0.60
BMAL1	contributes_to	gene	0.60
CRY1	contributes_to	gene	0.60
ICAM1	activates	gene	0.60
OCLN	contributes_to	gene	0.60
TNF	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Can circadian interventions reverse microglial priming independent of sleep disr

chronobiology | 2026-04-08 | 7 hypotheses Top: 0.455

How does sevoflurane-induced NF-κB activation specifically trigger complement ca

neuroinflammation | 2026-04-08 | 5 hypotheses Top: 0.658

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

While the study demonstrates both NF-κB pathway activation and increased C1qa ex

closed · Rounds: 4 · Score: 0.74 · 2026-04-21

Can circadian interventions reverse microglial priming independent of sleep disr

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Related Research

Hypotheses and analyses mentioning TNFRSF1A in their description or question text

No additional research found