gene

IKBKB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IKBKB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

154Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

IKBKB is a gene implicated in neurodegeneration research. Key relationships include: activates, expressed in, associated with. Associated with Als, Alzheimer, Autoimmune. Connected to 133 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IKBKB
Full Name	IκB Kinase Beta
Aliases	IKKβ, IKK-B
Chromosome	8p11.21
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	87 kDa
Amino Acids	756 aa
Exons	22
Pathways	NF-κB, NF-κB signaling
UniProt ID	O14920
NCBI Gene ID	3551
Ensembl ID	ENSG00000111640
GeneCards	IKBKB
Human Protein Atlas	IKBKB
Associated Diseases	Als, Autoimmune, Ms, Rheumatoid Arthritis
Interactions	GAIN, MTOR, CHUK, IL6, LC3, PRDX6
KG Connections	154 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: IKBKB — AlphaFold O14920 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    IKBKB["IKBKB"]
    IKBKB -->|"activates"| Cancer["Cancer"]
    IKBKB -.biomarker for.-> Alzheimer["Alzheimer"]
    IKBKB -.biomarker for.-> Als["Als"]
    IKBKB -->|"expressed in"| Lymphoma["Lymphoma"]
    IKBKB -->|"expressed in"| Ms["Ms"]
    IKBKB -->|"expressed in"| Tumor["Tumor"]
    IKBKB -->|"activates"| Epilepsy["Epilepsy"]
    IKBKB -->|"inhibits"| Mtor["Mtor"]
    CHUK["CHUK"] -->|"inhibits"| IKBKB
    GAIN["GAIN"] -->|"inhibits"| IKBKB
    MTOR["MTOR"] -->|"inhibits"| IKBKB
    P38["P38"] -->|"activates"| IKBKB
    MAP1LC3["MAP1LC3"] -->|"activates"| IKBKB
    IL1B["IL1B"] -->|"activates"| IKBKB
    PRDX1["PRDX1"] -->|"activates"| IKBKB
    TRAF6["TRAF6"] -->|"activates"| IKBKB
    PRDX6["PRDX6"] -->|"activates"| IKBKB

Outgoing (75)

Target	Relation	Type	Str
Cancer	activates	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Lymphoma	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Epilepsy	activates	disease	0.65
Ms	activates	disease	0.65
Ms	associated_with	disease	0.65
Infection	activates	disease	0.65
Autoimmune	associated_with	disease	0.65
Rheumatoid Arthritis	associated_with	disease	0.65
Als	associated_with	disease	0.65
GAIN	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
CHUK	inhibits	gene	0.60
IL6	activates	gene	0.60
LC3	activates	gene	0.60
PIK3R1	biomarker_for	gene	0.60
HDAC2	biomarker_for	gene	0.60
PRDX6	activates	gene	0.60
RELA	activates	gene	0.60
TAK1	activates	gene	0.60
PRDX1	activates	gene	0.60
HSPA1B	expressed_in	gene	0.60
HSPE1	expressed_in	gene	0.60
HSP90AB1	expressed_in	gene	0.60
HSP70	expressed_in	gene	0.60
HSPH1	expressed_in	gene	0.60
HSPA1L	expressed_in	gene	0.60
HSPA1A	expressed_in	gene	0.60
DNAJC10	expressed_in	gene	0.60
ECSIT	activates	gene	0.60
MAP3K7	activates	gene	0.60
CASP8	associated_with	gene	0.60
RANK	associated_with	gene	0.60
AKT	associated_with	gene	0.60
MYC	associated_with	gene	0.60
HSP60	expressed_in	gene	0.60
DNAJB1	expressed_in	gene	0.60
Mtor	inhibits	pathway	0.60
Tgf-Β	therapeutic_target	pathway	0.60
Mapk	therapeutic_target	pathway	0.60
DSDNA	therapeutic_target	gene	0.60
NFKB	activates	gene	0.60
Nf-Kb	activates	pathway	0.60
Autophagy	activates	pathway	0.60
Mapk	activates	pathway	0.60
GENES	biomarker_for	gene	0.60

Incoming (79)

Source	Relation	Type	Str
IKBKG	interacts_with	protein	0.90
STAT3	associated_with	gene	0.70
CHUK	inhibits	gene	0.60
GAIN	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
P38	activates	gene	0.60
IL1B	activates	gene	0.60
PRDX1	activates	gene	0.60
TRAF6	activates	gene	0.60
CHUK	activates	gene	0.60
PRDX6	activates	gene	0.60
MAPK14	activates	gene	0.60
BECN1	activates	gene	0.60
TNF	activates	gene	0.60
ECSIT	activates	gene	0.60
MAP3K7	activates	gene	0.60
TLR4	activates	gene	0.60
RELA	activates	gene	0.60
TAK1	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
LC3	activates	gene	0.60
UBIQUITIN	expressed_in	gene	0.60
BAG3	expressed_in	gene	0.60
UBC	expressed_in	gene	0.60
HSPD1	expressed_in	gene	0.60
DNAJC7	expressed_in	gene	0.60
HSPA6	expressed_in	gene	0.60
DNAJB1	expressed_in	gene	0.60
TLR4	expressed_in	gene	0.60
TLR3	expressed_in	gene	0.60
RAGE	expressed_in	gene	0.60
IRAK2	expressed_in	gene	0.60
IL10	expressed_in	gene	0.60
IRAK1	expressed_in	gene	0.60
IKBKG	expressed_in	gene	0.60
TLR2	expressed_in	gene	0.60
TLR1	expressed_in	gene	0.60
HMGB1	expressed_in	gene	0.60
BCL2L1	associated_with	gene	0.60
CASP1	associated_with	gene	0.60
NFKBIA	associated_with	gene	0.60
CASP8	associated_with	gene	0.60
IL1B	associated_with	gene	0.60
XIAP	associated_with	gene	0.60
AKT1	associated_with	gene	0.60
CFLAR	associated_with	gene	0.60
RIPK1	associated_with	gene	0.60
NFH	associated_with	gene	0.60
TNFRSF1A	associated_with	gene	0.60
IL6	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IKBKB

Understanding Entity Pages

Summary

Wiki Pages (21)

IKBKB Gene

NF-kB Signaling Pathway in Neurodegeneration

ARRB2 — Arrestin Beta 2

CHUK — IKK Alpha (IκB Kinase Alpha)

IKBKG Gene

ECSIT — Evolutionarily Conserved Signaling Intermediate in Toll Pathways

NF-κB Signaling in Parkinson's Disease

IKKβ Protein

Neurofilament Heavy Chain (NfH)

IKKBETA Gene

DnaJ Heat Shock Protein Family (Hsp40) Member C7

NFKB2 Gene

IKBKB Protein

HSPA6

NFKBIA Protein

IKBKG Protein

TLR1 Gene

HSPH1 Gene

NEFH Gene