CFLAR

Understanding Entity Pages

This page aggregates everything SciDEX knows about CFLAR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

CFLAR encodes c-FLIP, a critical regulator of apoptosis and necroptosis pathways with significant implications for neurodegenerative diseases and cancer therapy.

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graph TD
    CFLAR["<b>CFLAR</b>"]
    Ms{"Ms"}
    CFLAR -->|"associated with"| Ms
    CFLAR -->|"expressed in"| Ms
    RIPK1["RIPK1"]
    CFLAR -->|"associated with"| RIPK1
    NFH["NFH"]
    CFLAR -->|"associated with"| NFH
    TNFRSF1A["TNFRSF1A"]
    CFLAR -->|"associated with"| TNFRSF1A
    IKBKB["IKBKB"]
    CFLAR -->|"associated with"| IKBKB
    Akt(["Akt"])
    CFLAR -->|"associated with"| Akt
    AUTOPHAGY["AUTOPHAGY"]
    CFLAR -->|"expressed in"| AUTOPHAGY
    APOPTOSIS["APOPTOSIS"]
    CFLAR -->|"expressed in"| APOPTOSIS
    VEGFA["VEGFA"]
    CFLAR -->|"expressed in"| VEGFA
    AUTOPHAGY_RELATED_GENES["AUTOPHAGY-RELATED GENES"]
    CFLAR -->|"expressed in"| AUTOPHAGY_RELATED_GENES
    Apoptosis(["Apoptosis"])
    CFLAR -->|"expressed in"| Apoptosis
    BCL2L1["BCL2L1"]
    BCL2L1 -->|"associated with"| CFLAR
    CASP1["CASP1"]
    CASP1 -->|"associated with"| CFLAR
    NFKBIA["NFKBIA"]
    NFKBIA -->|"associated with"| CFLAR
    CASP8["CASP8"]
    CASP8 -->|"associated with"| CFLAR
    IL1B["IL1B"]
    IL1B -->|"associated with"| CFLAR
    XIAP["XIAP"]
    XIAP -->|"associated with"| CFLAR
    AKT1["AKT1"]
    AKT1 -->|"associated with"| CFLAR
    STAT3["STAT3"]
    STAT3 -->|"associated with"| CFLAR
    FAS["FAS"]
    FAS -->|"expressed in"| CFLAR
    MIRNAS["MIRNAS"]
    MIRNAS -->|"associated with"| CFLAR
    RELA["RELA"]
    RELA -->|"expressed in"| CFLAR
    ATF6["ATF6"]
    ATF6 -->|"expressed in"| CFLAR
    style CFLAR fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0