Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Neuroprotection | mediates | process | 0.90 |
| Learning And Memory | involved_in | process | 0.90 |
| NEURON | protects_against | cell_type | 0.80 |
| Neurons | modulates | cell_type | 0.75 |
| Astrocytes | modulates | cell_type | 0.75 |
| ASTROCYTES | causes | cell_type | 0.64 |
| NEURONS | causes | cell_type | 0.64 |
| Source | Relation | Type | Str |
|---|---|---|---|
| 19371326 | combines with | paper | 0.90 |
| MICROGLIAL CELL | produces | cell_type | 0.80 |
| DHT | inhibits | compound | 0.80 |
| MICROGLIA | activates | cell_type | 0.64 |
| PLGF | activates | protein | 0.56 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Mobile App-Based Intervention for BPSD in Community-Dwelling Dementia | clinical | dementia with behavioral and p | 0.950 | 0.00 | human patients | proposed | N/A |
| GPR109A receptor validation using knockout macrophages | exploratory | Mycoplasma pneumoniae pneumoni | 0.920 | 0.00 | GPR109A knockout mouse macroph | proposed | N/A |
| Periodontitis-induced colonic inflammation in mice | validation | Periodontitis and intestinal i | 0.900 | 0.00 | C57BL/6J mice | proposed | N/A |
| Fecal microbiota transplantation from periodontitis donors | validation | Periodontitis-associated gut d | 0.900 | 0.00 | Germ-free mice with fecal micr | proposed | N/A |
| GPR109A functional modulation with pharmacological agents | validation | Periodontitis with intestinal | 0.880 | 0.00 | C57BL/6J mice with ligature-in | proposed | N/A |
| Probiotic CBM588 supplementation rescue experiment | validation | Periodontitis-associated intes | 0.850 | 0.00 | C57BL/6J mice with periodontit | proposed | N/A |
| Proposed experiment from debate on Senolytics targeting p16/p21+ senes | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Mechanism: Why Does Amyloid Removal Only Slow Decline 27%? | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| cGAS-STING Pathway Validation Study in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,100,000 |
| Microglial Aging and Immune Memory in Neurodegeneration — Training the | validation | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $2,960,000 |
| Microglial Contributions to Huntington's Disease Pathogenesis | validation | Neuroinflammation | 0.400 | 0.50 | human | proposed | $2,960,000 |
| Mixed Pathology Effects on Parkinson's Disease Progression and Treatme | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| NLRP3 Inflammasome Validation Study in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Senolytic Therapy (D+Q) Phase IIa Trial in Early Alzheimer's Disease | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Traumatic Brain Injury and Alzheimer's Disease Relationship | validation | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $3,000,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Caloric Restriction Intervention Alters Specific Circulating Biomarkers of the S [PMID:37738560] | Justice JN, Leng XI, LeBrasseur NK, Tchk | J Gerontol A Biol Sci Med Sci | 2024 | 1 |
| Sex differences in autophagy-mediated diseases: toward precision medicine. [PMID:32264724] | Shang D, Wang L, Klionsky DJ, Cheng H, Z | Autophagy | 2021 | 1 |
| Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populatio [PMID:33144684] | He D, Wang D, Lu P, Yang N, Xue Z, Zhu X | Oncogene | 2021 | 1 |
| Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiqui [PMID:30966861] | ["Han X", "Sun S", "Sun Y", "Song Q", "Z | Autophagy | 2020 | 1 |
| Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells [PMID:26657143] | Chang J, Wang Y, Shao L, Laberge RM, Dem | Nat Med | 2016 | 1 |
| The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. [PMID:25754370] | Zhu Y, Tchkonia T, Pirtskhalava T, Gower | Aging Cell | 2015 | 1 |
| GPR109a-AMPK axis mediates the Attenuation of uric acid-induced M1 macrophage po [PMID:41882026] | Du M, He Y, Zhu Y, Chen W, Chen X, Yang | Scientific reports | 2026 | 0 |
| Gut microbiota-derived isovaleric acid alleviates atrial fibrillation by suppres [PMID:41638192] | Ding N, Wu H, Hua Y, Hua R, Li B, Xie Y, | Cell metabolism | 2026 | 0 |
| Senolytic elimination of therapy-induced senescent cells by ABT-263 improves che [PMID:41423036] | Zhang D, Zhu J, Zou R, Zhang H, Yu BP, L | Biochemical pharmacology | 2026 | 0 |
| Therapeutic strategies for hypertension: exploring the role of microbiota-derive [PMID:40637840] | Tortelote GG | Pediatr Nephrol | 2026 | 0 |
| Peripheral cancer attenuates amyloid pathology in Alzheimer's disease via cystat [PMID:41576952] | Li X, Tang X, Zeng J, Duan L, Hou Z et a | Cell | 2026 | 0 |
| UNC93B1 promotes pancreatic cancer progression through modulation of cGAS-STING [PMID:41716413] | Yang H, Li Y, Su J, Zhang H, Zhu W et al | Front Immunol | 2026 | 0 |
| Comprehensive assessment of the genomic stability of human induced pluripotent s [PMID:41877289] | Zhang K, Na T, Jia C, Yuan X, Guo M, Yan | Stem cell research & therapy | 2026 | 0 |
| Characterization of the Direct and Indirect Inhibition of Apoptosis by Full-Leng [PMID:41589352] | Elsner C, Epasto LM, Cieren A, Gendreizi | Chembiochem : a European journ | 2026 | 0 |
| Xin-Jia-Tong-Xie-Yao-Fang restores the intestinal barrier to alleviate irritable [PMID:41655800] | Zhu J, Yang L, Fang Z, Chen J, Fu R, Liu | Microbial pathogenesis | 2026 | 0 |
| Exploring the key molecular mechanisms and immune microenvironment of oxidative [PMID:41591671] | Cai Z, Li J, Li T, Peng Q | Discover oncology | 2026 | 0 |
| Cranberry extract-supplemented microbiota effluents enhance intestinal barrier i [PMID:41680408] | Cattero V, Mayer T, Veilleux A, Roussel | Scientific reports | 2026 | 0 |
| Qingfei Tongluo Jiedu Formula Regulates M2 Macrophage Polarization via the Butyr [PMID:41754753] | Liu Z, Fan Q, Sun R, Jiang Y | Pharmaceuticals (Basel, Switze | 2026 | 0 |
| Periodontitis promotes intestinal inflammation through gut microbiota-mediated s [PMID:41816355] | Wang X, Xu Z, Yao Y, Jia H, Du M, Wang S | Frontiers in cellular and infe | 2026 | 0 |
| Hydroxycarboxylic acid receptor 2 (GPR109A) and retinopathies: pathways and pros [PMID:41889514] | Lester J, Amamoo R, Thounaojam MC, Marti | Frontiers in medicine | 2026 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning NO in their description or question text
Score: 0.802 · lipidomics · 2026-04-25
The hypothesis proposes that ω-3 docosahexaenoic acid (DHA) is metabolized by CYP2J2 to generate protective epoxides tha
Score: 0.800 · multi · 2026-04-28
Shared mechanism across AD, PD: Misfolded protein stress activates microglial NLRP3; IL-1 beta and inflammasome signalin
Score: 0.791 · neurodegeneration · 2026-04-02
## Mechanistic Overview Senescent Microglia Resolution via Maresins-Senolytics Combination starts from the claim that mo
Score: 0.780 · neurodegeneration · 2026-04-26
G2019S basal RAB10 phosphorylation elevation may be secondary; true pathogenic driver is amplified stress-response signa
Score: 0.776 · neurodegeneration · 2026-04-16
## Mechanistic Overview CX3CR1-TREM2 Integration for Synapse Pruning Normalization starts from the claim that modulating
Score: 0.770 · neurodegeneration · 2026-04-22
## Mechanistic Overview H3: SIRT1 Insufficiency Disconnects Metabolic Sensing from Epigenomic Homeostasis starts from th
Score: 0.763 · neuroscience · 2026-04-22
**Molecular Mechanism and Rationale** The molecular basis for selective liver X receptor beta (LXRβ/NR1H2) agonism in A
Score: 0.760 · neurodegeneration · 2026-04-28
TDP-43 misfolding and aggregation occurs as primary pathology in ALS/FTD (~95% and ~50% respectively) and as secondary p
Score: 0.743 · neuroinflammation · 2026-04-21
**Molecular Mechanism and Rationale** The proposed mechanism centers on liver disease-induced breakdown of blood-brain
Score: 0.742 · neurodegeneration · 2026-04-02
## Mechanistic Overview APOE4-Selective Lipid Nanoemulsion Therapy starts from the claim that modulating APOE within the
Score: 0.740 · neurodegeneration · 2026-04-25
Transient Aβ exposure induces dendritic tau missorting that then converts into a locally self-propagating tau oligomer/s
Score: 0.730 · neurodegeneration · 2026-04-02
## Mechanistic Overview Adenosine-Astrocyte Metabolic Reset starts from the claim that modulating ADORA2A within the dis
Score: 0.725 · neurodegeneration · 2026-04-02
## Mechanistic Overview TFAM overexpression creates mitochondrial donor-recipient gradients for directed organelle traff
Score: 0.720 · neurodegeneration · 2026-04-22
**Molecular Mechanism and Rationale** The NLRP3 (NACHT, LRR and PYD domains-containing protein 3) inflammasome represen