Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NPL4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | NPL4 |
| Aliases | NPL4 protein |
| Function | NPL4 (nuclear protein localization 4 homolog) is a cofactor for VCP/p97 that forms a heterodimeric complex with UFD1. The UFD1-NPL4 complex recognizes ubiquitinated substrates and delivers them to ... |
| Subcellular Localization | 4)</th></tr> <tr><td>Gene</td><td>NPLOC4</td></tr> <tr><td>UniP |
| Molecular Weight | 68.6 kDa |
| Pathways | ubiquitin-proteasome, autophagy pathway |
| GeneCards | NPL4 |
| Human Protein Atlas | NPL4 |
| Associated Diseases | ALS, dementia, frontotemporal |
| Interactions | UBXD1, UFD1, VCP, PIK3C3, RPL26, RPN1 |
| KG Connections | 29 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NPL4(["NPL4"])
style NPL4 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
UBXD1["UBXD1"]
UFD1(["UFD1"])
VCP["VCP"]
ubiquitin_proteasome(("ubiquitin-proteasome"))
autophagy_pathway(("autophagy pathway"))
NPL4 -->|"interacts_with"| UBXD1
NPL4 -->|"interacts_with"| UFD1
NPL4 -->|"interacts_with"| VCP
NPL4 -->|"participates_in"| ubiquitin_proteasome
NPL4 -->|"participates_in"| autophagy_pathway
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
class UBXD1 gene
class UFD1 protein
class VCP gene
class ubiquitin_proteasome pathway
class autophagy_pathway pathway| Target | Relation | Type | Str |
|---|---|---|---|
| ALS | associated_with | disease | 0.60 |
| dementia | associated_with | disease | 0.60 |
| frontotemporal | associated_with | disease | 0.60 |
| PIK3C3 | activates | gene | 0.60 |
| RPL26 | activates | gene | 0.60 |
| RPN1 | activates | gene | 0.60 |
| SQSTM1 | activates | gene | 0.60 |
| UFD1 | activates | gene | 0.60 |
| UFL1 | activates | gene | 0.60 |
| UFM1 | activates | gene | 0.60 |
| UVRAG | activates | gene | 0.60 |
| VCP | activates | gene | 0.60 |
| ALS | activates | disease | 0.60 |
| frontotemporal dementia | activates | disease | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| UBXD1 | regulates | gene | 0.60 |
| VCP | regulates | gene | 0.60 |
| UBXD1 | interacts_with | gene | 0.55 |
| UFD1 | interacts_with | gene | 0.55 |
| VCP | interacts_with | gene | 0.55 |
| ubiquitin-proteasome | participates_in | pathway | 0.55 |
| autophagy pathway | participates_in | pathway | 0.55 |
| PIK3C3 | co_expressed_with | gene | 0.50 |
| RPL26 | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||