gene

ATG14

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATG14: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

330Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

ATG14 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, Aging, Als. Connected to 214 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ATG14
Full Name	Autophagy Related 14
Chromosome	10q26.3
Function	is a crucial autophagy protein that plays a central role in the initiation of autophagosome formation.
Amino Acids	492 aa
Exons	12
Pathways	Apoptosis, Autophagy, Cell Cycle, Epithelial-Mesenchymal Transition, Inflammasome
UniProt ID	Q9Y5P8
NCBI Gene ID	22889
Ensembl ID	ENSG00000131725
OMIM	614113
GeneCards	ATG14
Human Protein Atlas	ATG14
Associated Diseases	ALS, Cancer, Infection, Lung Cancer, Tumor, dementia
Interactions	STX17, BECN1, UVRAG, PIK3C3, TP53, LC3
KG Connections	330 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ATG14 — AlphaFold Q9Y5P8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ATG14["ATG14"] -->|"biomarker for"| Aging["Aging"]
    ATG14["ATG14"] -->|"biomarker for"| Als["Als"]
    ATG14["ATG14"] -->|"regulates"| Alzheimer["Alzheimer"]
    ATG14["ATG14"] -->|"interacts"| Als_1["Als"]
    ATG14["ATG14"] -->|"regulates"| Als_2["Als"]
    ATG14["ATG14"] -->|"activates"| Als_3["Als"]
    NRBF2["NRBF2"] -->|"regulates"| ATG14["ATG14"]
    NRBF2_4["NRBF2"] -->|"interacts"| ATG14["ATG14"]
    ACTB["ACTB"] -->|"associated"| ATG14["ATG14"]
    CDC42["CDC42"] -->|"associated"| ATG14["ATG14"]
    style ATG14 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (218)

Target	Relation	Type	Str
ER-Mitochondria Contact Site	associated_with	mechanism	0.95
ER-Mitochondria Contact Sites	associated_with	organelle	0.95
autophagosome formation	involved_in	process	0.93
Autophagy	associated_with	pathway	0.90
Autophagosome Formation	biomarker_for	process	0.85
lipid_droplets	targets	biological_process	0.80
Als	regulates	disease	0.75
ATG16L1	associated_with	gene	0.70
MAP1LC3A	associated_with	gene	0.70
Autophagy	regulates	pathway	0.70
AUTOPHAGY	associated_with	gene	0.70
APOPTOSIS	associated_with	gene	0.70
Apoptosis	associated_with	pathway	0.70
AUTOPHAGY	activates	gene	0.70
Autophagy	activates	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
Aging	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Alzheimer	regulates	disease	0.65
Als	interacts_with	disease	0.65
Als	activates	disease	0.65
Aging	activates	disease	0.65
Cancer	activates	disease	0.65
Senescence	activates	disease	0.65
ALS	biomarker_for	disease	0.65
Tumor	activates	disease	0.65
Melanoma	activates	disease	0.65
Infection	activates	disease	0.65
Bacterial Infection	activates	disease	0.65
Inflammation	activates	disease	0.65
Cancer	associated_with	disease	0.65
Lung Cancer	associated_with	disease	0.65
Ulcerative Colitis	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Tumor	associated_with	disease	0.65
Lung Cancer	activates	disease	0.65
Parkinson	activates	disease	0.65
Diabetes	regulates	disease	0.65
Cancer	regulates	disease	0.65
Nafld	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Fatty Liver	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Infection	associated_with	disease	0.65
Atherosclerosis	activates	disease	0.65
GJA1	associated_with	gene	0.60
LAMP1	regulates	gene	0.60
STX17	interacts_with	gene	0.60
ATG5	biomarker_for	gene	0.60
GAPDH	associated_with	gene	0.60

Incoming (112)

Source	Relation	Type	Str
STX17	binds	protein	0.90
Starvation	activates	process	0.90
Starvation	upregulates	phenotype	0.85
STX18	binds	protein	0.80
PtdIns(4,5)P2	binds	chemical	0.80
BECN2	binds	protein	0.80
YTHDF1	associated_with	protein	0.80
AUTOPHAGY	associated_with	gene	0.80
ACTB	associated_with	gene	0.70
BECN1	associated_with	gene	0.70
PIK3C3	regulates	gene	0.70
LC3	activates	gene	0.70
BECN1	activates	gene	0.70
NRBF2	regulates	protein	0.70
NRBF2	interacts_with	protein	0.70
PI3KC3	regulates	gene	0.70
CDC42	associated_with	gene	0.60
CASP3	associated_with	gene	0.60
SQSTM1	regulates	gene	0.60
TUBB3	regulates	gene	0.60
STK11	regulates	gene	0.60
VIM	regulates	gene	0.60
HDAC6	regulates	gene	0.60
GAPDH	associated_with	gene	0.60
MAP1LC3B	regulates	gene	0.60
MAP3K5	regulates	gene	0.60
UVRAG	regulates	gene	0.60
H2AX	associated_with	gene	0.60
OCLN	regulates	gene	0.60
RAC1	regulates	gene	0.60
GJA1	associated_with	gene	0.60
LAMP1	regulates	gene	0.60
P62	regulates	gene	0.60
ATG5	biomarker_for	gene	0.60
FIP200	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
ATG13	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
BCL2	associated_with	gene	0.60
TUBULIN	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
VIMENTIN	regulates	gene	0.60
STX17	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
APP	regulates	gene	0.60
RAB7	regulates	gene	0.60
ASC	activates	gene	0.60
AIM2	activates	gene	0.60
SQSTM1	activates	gene	0.60
VAMP8	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ATG14

Understanding Entity Pages

Summary

Wiki Pages (21)

ATG14 Gene

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RAC1 Gene

fip200

VAMP7 Gene

CBS Autophagy-Lysosomal Pathway Dysfunction

ATG14 Protein

RAC1 Protein

WIPI1 Gene

macroautophagy-dysfunction-parkinsons

LYST Gene — Lysosomal Trafficking Regulator

Autophagy Molecular Regulation in Neurodegeneration

MITF Gene — Microphthalmia-Associated Transcription Factor

ATG17A

tmem9-protein

Lipophagy Activation Therapy for Neurodegeneration

GABARAP Protein