Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about UFM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
UFM1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, interacts with. Associated with Aging, Als, Cancer. Connected to 38 entities in the SciDEX knowledge graph.
| Gene Symbol | UFM1 |
| Full Name | Ubiquitin-like Modifier 1 |
| Function | encodes a ubiquitin-like protein that undergoes unique post-translational modification through ufmylation. |
| Subcellular Localization | - Cytoplasm, particularly near the ER |
| Amino Acids | 83 aa |
| Pathways | Autophagy |
| GeneCards | UFM1 |
| Human Protein Atlas | UFM1 |
| UFC1 | Enzyme-substrate |
| UFL1 | Enzyme-substrate |
| UFSP2 | Protease |
| AKT1 | Signaling |
| PERK | Stress response |
| Associated Diseases | ALS, Alzheimer, Cancer, dementia, frontotemporal |
| Interactions | BECN1, NLRP3, VCP, UVRAG, PYROPTOSIS, AUTOPHAGY |
| KG Connections | 93 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
UFM1["<b>UFM1</b>"]
Cancer{"Cancer"}
UFM1 -->|"associated with"| Cancer
Tumor{"Tumor"}
UFM1 -->|"activates"| Tumor
UFM1 -->|"regulates"| Cancer
Als{"Als"}
UFM1 -->|"regulates"| Als
UFM1 -->|"interacts with"| Als
Aging{"Aging"}
UFM1 -->|"interacts with"| Aging
UFM1 -->|"interacts with"| Cancer
Multiple_Sclerosis{"Multiple Sclerosis"}
UFM1 -->|"interacts with"| Multiple_Sclerosis
UFM1 -->|"therapeutic target"| Cancer
UFM1 -->|"expressed in"| Tumor
ATXN3["ATXN3"]
UFM1 -->|"regulates"| ATXN3
BECN1["BECN1"]
UFM1 -->|"activates"| BECN1
GENES["GENES"]
GENES -->|"activates"| UFM1
LC3B["LC3B"]
LC3B -->|"regulates"| UFM1
MAP1LC3B["MAP1LC3B"]
MAP1LC3B -->|"regulates"| UFM1
VCP["VCP"]
VCP -->|"activates"| UFM1
UBIQUITIN["UBIQUITIN"]
UBIQUITIN -->|"associated with"| UFM1
AND["AND"]
AND -->|"associated with"| UFM1
style UFM1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ASC1 | modulates | protein | 0.95 |
| Breast Cancer Development | contributes_to | disease | 0.90 |
| ASC1 | modifies | protein | 0.90 |
| ESR1 | regulates | protein | 0.88 |
| Breast Cancer | involved_in | disease | 0.85 |
| RPL26 | binds | protein | 0.80 |
| Cancer | associated_with | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Aging | interacts_with | disease | 0.65 |
| Cancer | interacts_with | disease | 0.65 |
| Multiple Sclerosis | interacts_with | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| ATXN3 | regulates | gene | 0.60 |
| BECN1 | activates | gene | 0.60 |
| NLRP3 | interacts_with | gene | 0.60 |
| MAVS | associated_with | gene | 0.60 |
| VCP | activates | gene | 0.60 |
| UBIQUITIN | regulates | gene | 0.60 |
| MAP1LC3B | regulates | gene | 0.60 |
| SLC7A11 | expressed_in | gene | 0.60 |
| UBIQUITIN | associated_with | gene | 0.60 |
| frontotemporal | associated_with | disease | 0.60 |
| UVRAG | activates | gene | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| PYROPTOSIS | interacts_with | gene | 0.60 |
| Inflammasome | interacts_with | pathway | 0.60 |
| Pyroptosis | interacts_with | pathway | 0.60 |
| LC3B | regulates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| FERROPTOSIS | activates | gene | 0.60 |
| CANCER | therapeutic_target | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
| Ferroptosis | activates | pathway | 0.60 |
| GENES | activates | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
| Autophagy | regulates | pathway | 0.60 |
| AND | associated_with | gene | 0.60 |
| Unfolded Protein Response | associated_with | pathway | 0.60 |
| Neuron | associated_with | cell_type | 0.60 |
| Ubiquitin | therapeutic_target | protein | 0.60 |
| Ras | activates | protein | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| ALS | associated_with | disease | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ASC1 | modified_by | gene | 0.90 |
| UBA5 | activates | enzyme | 0.85 |
| MAP1LC3B | regulates | gene | 0.60 |
| VCP | activates | gene | 0.60 |
| UBIQUITIN | associated_with | gene | 0.60 |
| BECN1 | activates | gene | 0.60 |
| ATG7 | regulates | gene | 0.60 |
| UBIQUITIN | therapeutic_target | entity | 0.60 |
| TAU | associated_with | gene | 0.60 |
| ASC1 | associated_with | gene | 0.60 |
| ASC1 | activates | gene | 0.60 |
| ATG14 | activates | gene | 0.60 |
| MAP1LC3B | activates | gene | 0.60 |
| PIK3C3 | activates | gene | 0.60 |
| RPL26 | activates | gene | 0.60 |
| RPN1 | activates | gene | 0.60 |
| SQSTM1 | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| LC3B | regulates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| AND | contributes_to | gene | 0.60 |
| NADH | inhibits | gene | 0.60 |
| GENES | contributes_to | gene | 0.60 |
| CANCER | activates | entity | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| UFL1 | activates | gene | 0.60 |
| LC3B | activates | gene | 0.60 |
| NPL4 | activates | gene | 0.60 |
| UFD1 | activates | gene | 0.60 |
| UFD1 | co_expressed_with | protein | 0.50 |
| UFL1 | co_expressed_with | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||