gene

UFM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UFM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

93Connections
0Hypotheses
0Analyses
50Outgoing
33Incoming

Summary

UFM1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, interacts with. Associated with Aging, Als, Cancer. Connected to 38 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolUFM1
Full NameUbiquitin-like Modifier 1
Functionencodes a ubiquitin-like protein that undergoes unique post-translational modification through ufmylation.
Subcellular Localization- Cytoplasm, particularly near the ER
Amino Acids83 aa
PathwaysAutophagy
GeneCardsUFM1
Human Protein AtlasUFM1
UFC1Enzyme-substrate
UFL1Enzyme-substrate
UFSP2Protease
AKT1Signaling
PERKStress response
Associated DiseasesALS, Alzheimer, Cancer, dementia, frontotemporal
InteractionsBECN1, NLRP3, VCP, UVRAG, PYROPTOSIS, AUTOPHAGY
KG Connections93 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

UFM1 — Ubiquitin-like Modifier 1

gene · 684 words

Novel Therapy Index

idea · 10647 words

RPL26

gene · 1666 words

UFL1 Protein (UFM1-Specific Protease 1)

protein · 1518 words

UFM1ylation Modulation Therapy for Neurodegeneration

idea · 1261 words

RPN1 Gene

gene · 806 words

Pathway Diagram

graph TD
    UFM1["<b>UFM1</b>"]
    Cancer{"Cancer"}
    UFM1 -->|"associated with"| Cancer
    Tumor{"Tumor"}
    UFM1 -->|"activates"| Tumor
    UFM1 -->|"regulates"| Cancer
    Als{"Als"}
    UFM1 -->|"regulates"| Als
    UFM1 -->|"interacts with"| Als
    Aging{"Aging"}
    UFM1 -->|"interacts with"| Aging
    UFM1 -->|"interacts with"| Cancer
    Multiple_Sclerosis{"Multiple Sclerosis"}
    UFM1 -->|"interacts with"| Multiple_Sclerosis
    UFM1 -->|"therapeutic target"| Cancer
    UFM1 -->|"expressed in"| Tumor
    ATXN3["ATXN3"]
    UFM1 -->|"regulates"| ATXN3
    BECN1["BECN1"]
    UFM1 -->|"activates"| BECN1
    GENES["GENES"]
    GENES -->|"activates"| UFM1
    LC3B["LC3B"]
    LC3B -->|"regulates"| UFM1
    MAP1LC3B["MAP1LC3B"]
    MAP1LC3B -->|"regulates"| UFM1
    VCP["VCP"]
    VCP -->|"activates"| UFM1
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"associated with"| UFM1
    AND["AND"]
    AND -->|"associated with"| UFM1
    style UFM1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (60)

TargetRelationTypeStr
ASC1modulatesprotein0.95
Breast Cancer Developmentcontributes_todisease0.90
ASC1modifiesprotein0.90
ESR1regulatesprotein0.88
Breast Cancerinvolved_indisease0.85

Incoming (33)

SourceRelationTypeStr
ASC1modified_bygene0.90
UBA5activatesenzyme0.85
MAP1LC3Bregulatesgene0.60
VCPactivatesgene0.60
UBIQUITINassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found